ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (5): 427-429.doi: 10.3969/j.issn.1674-3865.2017.05.020

• 临床研究 • 上一篇    下一篇

重组人干扰素α-2b喷雾剂治疗疱疹性咽峡炎患儿疗效观察

姚婷新，廖亦男，谷芬，于四景，尹飞   

  1. 410007 长沙，湖南省儿童医院感染科（姚婷新，廖亦男，谷芬，于四景）;410008 长沙，中南大学湘雅医院儿科（尹飞）
  • 出版日期:2017-10-25 发布日期:2017-12-18
  • 通讯作者: 尹飞，E-mail：670932256@qq.com
  • 作者简介:姚婷新（1985-），女，医学硕士，主治医师。研究方向：儿科感染性疾病的诊治

Clinical effect of recombinant human interferon α-2b spray on herpangina in children

YAO Tingxin，LIAO Yinan，GU Fen，YU Sijing，YIN Fei   

  1. Department of Infectious Diseases， Hunan Children's Hospital，Changsha 410007，China
  • Online:2017-10-25 Published:2017-12-18

PDF (PC)

287

摘要：
目的
评价重组人干扰素α-2b喷雾剂对疱疹性咽峡炎患儿的疗效和安全性，为儿科合理用药提供科学依据。
方法
选取2015年9月至12月在湖南省儿童医院、中南大学湘雅医院进行诊治的疱疹性咽峡炎患儿122例，随机分为观察组和对照组各61例。对照组给予基础治疗联合利巴韦林喷雾剂，观察组给予基础治疗联合重组人干扰素α-2b喷雾剂。比较两组患儿临床疗效。
结果
观察组临床总有效率为80.3%（49/61），显著高于对照组63.9%（39/61）,差异有统计学意义(P<0.05)。观察组在退热时间、口腔疱疹消失时间、咽部疱疹消失时间、恢复进食时间均显著低于对照组,差异有统计学意义(P<0.05)。治疗过程中，两组患儿均未发现明显不良反应。
结论
重组干扰素α-2b治疗疱疹性咽峡炎疗效显著，能显著改善疱疹性咽峡炎患儿的热程和疱疹消退及进食时间，且未发现不良反应，安全性良好。

关键词: 疱疹性咽峡炎, 重组人干扰素α-2b喷雾剂, 儿童

Abstract:
Objective
To evaluate the efficacy and safety of recombinant human interferon α-2b(IFN α-2b) spray on herpangina in children, in order to provide scientific evidence for proper administration in pediatrics.
Methods
A total of 122 children with herpangina at Hunan Children's Hospital and Xiangya Hospital were randomly assigned to two groups: the control group(n=61) treated with ribavirin and conventional therapy,and the observation group(n=61) treated with recombinant human IFN α-2b spray and conventional therapy．The clinical efficacy was evaluate．
Results
The total clinical effective rate of the observation group was 80.3%（49/61）,significantly higher than the control group(63.9%,49/61）. The defervescence time，oral and pharynx herpes disappearance time and the eating-recovery time in observation group were significantly shorter than those in control group(P<0.05).During the treatment, there were no adverse drug reactions in both groups.
Conclusion
Recombinant human interferon α-2b spray has significant effect and safety, which can significantly improve the fever course of children with herpangina and shorten the herpes disappearance time and eating-recovery time; there is no adverse reaction.

Key words: Herpangina, Recombinant human interferon α-2b spray, Child