ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2020, Vol. 12 ›› Issue (6): 477-.

• 临床论著 • 上一篇    下一篇

“冬病夏治”穴位贴敷疗法治疗儿童咳嗽变异性哮喘的Meta分析

李盼盼，吴力群，徐方蔚，王东升，路晨，洪婧瑜   

  1. 100029北京，北京中医药大学2019级中医儿科学专业研究生（李盼盼，路晨，洪婧瑜），2018级中医儿科学专业研究生（徐方蔚，王东升）；100071 北京，北京中医药大学东方医院儿科（吴力群）
  • 出版日期:2020-12-25 上线日期:2021-05-14
  • 通讯作者: 吴力群，E-mail:wulq1211@163.com
  • 作者简介:李盼盼（1990-），女，北京中医药大学2019级中医儿科学博士研究生在读。研究方向：中医药防治小儿肺系疾病
  • 基金资助:
    国家自然科学基金面上资助项目（81874487）

Meta-analysis of acupoint application therapy of "summer treatment for winter disease" for children with cough variant asthma

LI Panpan，WU Liqun，XU Fangwei，WANG Dongsheng, LU Chen，HONG Jingyu.   

  1. Beijing University of Chinese Medicine，Beijing 100029，China
  • Published:2020-12-25 Online:2021-05-14

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摘要： 目的:系统评价“冬病夏治”穴位贴敷治疗儿童咳嗽变异性哮喘的有效性。
方法:用计算机检索自建库至2020年2月中国期刊全文数据库（CNKI）、万方数据库、维普全文期刊数据库（VIP）、中国生物医学文献数据库（CBM）、PubMed、Cochrance Library、EMBase数据库中关于“冬病夏治”穴位贴敷疗法治疗儿童咳嗽变异性哮喘的临床研究文献，选择符合纳入标准的临床试验进行Meta分析。
结果:共纳入10篇随机对照试验，总计826例患儿，统计分析显示穴位贴敷治疗咳嗽变异性哮喘的总有效率优于对照组。在肺功能检测及哮喘控制测试（ACT）评分，1秒用力呼气容积（FEV1）、第一秒用力呼气量/最大肺活量（FEV1/FVC）、呼气峰流速值（PEF）及ACT评分比较试验组优于对照组，差异有统计学意义（P<0.05）。在免疫球蛋白方面，治疗后试验组IgM、IgG、IgA值明显高于对照组，IgE值明显低于对照组，差异有统计学意义（P<0.05）。
结论:“冬病夏治”穴位贴敷疗法能提高咳嗽变异性哮喘患儿治疗的总有效率，改善肺通气功能，调节机体免疫状态。受纳入研究数量和质量的限制，尚需大样本、高质量的研究进一步验证本结论。

关键词: 咳嗽变异性哮喘, 冬病夏治, 穴位贴敷, 随机对照试验, Meta分析

Abstract: Objective:To systematically evaluate the effectiveness of "summer treatment for winter disease" acupoint applications in the treatment of cough variant asthma(CVA) in children.
Methods:Relevant studies of "summer treatment for winter disease" acupoint applications in the treatment of CVA in children were retrieved from electronic databases including China National Knowledge Infrastructure(CNKI), Wanfang database, Chongqing VIP information Chinese scientific journals database(VIP), Chinese Biomedical Literature database(CBM), PubMed, Cochrane Library and Embase database, from the inception to February 2020. Meta-analysis was conducted on the clinical trials selected according to the inclusion criteria.
Results:In total, 10 randomized controlled trials(RCTs) involving 826 children were selected the meta-analysis. The analysis indicated that the use of acupoint applications in the treatment group was more effective than in the control group. In terms of the pulmonary function test and ACT scores, the forced expiratory volume in the first second(FEV1), forced expiratory volume in the first second/forced vital capacity(FEV1/FVC), peak expiratory flow rate(PEF) and ACT scores were better in the treatment group than in the control group, and the difference was statistically significant(P<0.05).In terms of immunoglobulins panel, IgM, IgG and IgA values in the treatment group were significantly higher than those in the control group, while IgE values of treatment group were significantly lower than those of the control group.
Conclusion:The acupoint applications therapy of"summer treatment for winter disease" can increase the overall efficacy of treatment in children with CVA improve the pulmonary function, and regulate the body's immune status. Limited by the number and quality of included studies, large samples and high-quality studies are needed to further verify this conclusion.

Key words: Cough variant asthma, Summer treatment for winter disease, Acupoint application, Randomized controlled trial, Metaanalysis