ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (2): 177-.

• 小儿中药应用研究 • 上一篇    下一篇

小青龙汤加减治疗外寒内饮型儿童咳嗽变异性哮喘的临床观察

万军，于宙，孙梦甜，杨祥正   

  1. 518100 广东 深圳，北京中医药大学深圳医院(龙岗)儿科
  • 出版日期:2021-04-25 发布日期:2021-05-18
  • 通讯作者: 杨祥正，E-mail：15001109135@163.com
  • 作者简介:万军（1988-），男，医学硕士，主治医师。研究方向：中西医防治儿童过敏性疾病研究
  • 基金资助:
    深圳市龙岗区医疗卫生科技计划项目（LGKCYLWS2020085）

Clinical observation of modified Xiaoqinglong decoction in the treatment of children with cough variant asthma of external cold and internal fluid type

WAN Jun,YU Zhou,SUN Mengtian,YANG Xiangzheng   

  1. Shenzhen Hospital of Beijing University of Chinese Medicine(Longgang)，Shenzhen 518100,China
  • Online:2021-04-25 Published:2021-05-18

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摘要： 目的：观察小青龙汤加减联合丙酸氟替卡松吸入气雾剂治疗外寒内饮型咳嗽变异性哮喘的临床疗效。
方法：选取2018年12月至2020年6月北京中医药大学深圳医院（龙岗）儿科门诊收治外寒内饮型咳嗽变异性哮喘患儿80例，随机分为观察组和对照组各40例。观察组应用小青龙汤加减联合丙酸氟替卡松吸入气雾剂，对照组单独应用丙酸氟替卡松吸入气雾剂治疗，治疗期为1个月。观察各组中医症状评分、临床疗效及复发率。
结果：观察组临床总有效率为95.0%（38/40），显著高于对照组75.0%（30/40），差异有统计学意义（P<0.05）。治疗后对照组喘息、咳嗽、咯痰积分显著高于观察组，差异有统计学意义（P<0.05）。治疗期结束后观察组复发率为10.0%（4/40），低于对照组27.5%（11/40），差异有统计学意义(P<0.05)。
结论：小青龙汤加减联合丙酸氟替卡松吸入气雾剂治疗咳嗽变异性哮喘外寒内饮证有显著疗效，能明显改善临床症状，降低复发率。

关键词: 咳嗽变异性哮喘, 小青龙汤加减, 外寒内饮型, 儿童

Abstract: Objective：To observe the clinical effect of modified Xiaoqinglong decoction combined with fluticasone propionate inhaled aerosol in the treatment of cough variant asthma of external cold and internal fluid type.
Methods：A total of 80 patients with cough variant asthma of external cold and internal fluid type were included and randomly divided into observation group(n=40)and control group(n=40). The observation group was treated with modified Xiaoqinglong decoction combined with fluticasone propionate inhaled aerosol, while the control group was treated with fluticasone propionate inhaled aerosol alone, and the treatment period was 1 month. The scores of TCM symptoms, clinical efficacy and recurrence rate of each group were observed.
Results：The total effective rate of the observation group and the control group was 95.0%(38/40) and 75.0%(30/40), respectively, with significant difference between the two groups(P<0.05). After treatment, the scores in wheezing, cough and expectoration of the control group were significantly higher than those of the observation group(P<0.05). After stopping the treatment, the recurrence rate in observation group was 10.0%(4/40), lower than that of control group(27.5%,11/40)(P<0.05).
Conclusion：Modified Xiaoqinglong decoction combined with fluticasone propionate inhaled aerosol has significant effect in the treatment of cough variant asthma of external cold and internal fluid type, which can significantly improve the clinical symptoms and reduce the recurrence rate.

Key words: Cough variant asthma, Modified Xiaoqinglong decoction, External cold and internal fluid type, Children