ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (4): 311-.

• 综述 • 上一篇    下一篇

川崎病抗冠状动脉血栓中西药物的应用进展

冠状动脉血栓是川崎病严重的并发症，已成为儿童获得性心脏病的重要原因之一。川崎病-冠状动脉血栓的发病机制目前仍在探究，其治疗方案和用药已成为研究热点。本文从中西医两方面回顾川崎病冠状动脉血栓治疗药物的应用。西医将川崎病-冠状动脉血栓治疗药物分为抗血小板药、抗凝药物和溶栓药。而中医以清热解毒、益气养阴和活血化瘀三种方药为治疗主线，同时强调“活血化瘀”方药必须贯穿川崎病-冠状动脉血栓治疗的始终。   

  1. 110016 沈阳，北部战区总医院新生儿科
  • 出版日期:2021-08-25 上线日期:2021-12-10
  • 通讯作者: 魏兵，E-mail：weib71@sina.com
  • 作者简介:齐双辉（1980-），女，医学硕士，主治医师。研究方向：儿童哮喘、支气管肺炎和川崎病的诊治
  • 基金资助:
    2017年辽宁省自然科学基金项目（20170540955）

Advances in the application of Chinese and western medicines for coronary artery thrombosis caused by Kawasaki disease

Coronary artery thrombosis (CAT) is a serious complication of Kawasaki disease (KD), which hasbecome one of the important causes of children's acquired heart disease. The pathogenesis of KD-CAT is still being explored, and itstreatment plan and medication has become a research hotspot. This paper reviews the application of KD-CAT from the aspects of traditional Chinese medicine and western medicine. In western medicine the drugs forKD-CAT are divided into antiplatelet, anticoagulant and thrombolytic drugs. In traditional Chinese medicine the drugs for clearing heat and detoxification, supplementing Qi and nourishing Yin, and promoting blood circulationand removing blood stasis are used as the main line of treatment, and it is emphasized that the prescription of "promoting blood circulation and removing blood stasis" must be used throughout the whole process of KD-CAT treatment.   

  1. Department of Neonatology, General Hospital of Northern Theater Command, Shenyang 110016, China
  • Published:2021-08-25 Online:2021-12-10

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摘要： 冠状动脉血栓是川崎病严重的并发症，已成为儿童获得性心脏病的重要原因之一。川崎病-冠状动脉血栓的发病机制目前仍在探究，其治疗方案和用药已成为研究热点。本文从中西医两方面回顾川崎病冠状动脉血栓治疗药物的应用。西医将川崎病-冠状动脉血栓治疗药物分为抗血小板药、抗凝药物和溶栓药。而中医以清热解毒、益气养阴和活血化瘀三种方药为治疗主线，同时强调“活血化瘀”方药必须贯穿川崎病-冠状动脉血栓治疗的始终。

关键词: 川崎病, 冠状动脉血栓, 西药, 中药, 进展

Abstract: Coronary artery thrombosis (CAT) is a serious complication of Kawasaki disease (KD), which hasbecome one of the important causes of children's acquired heart disease. The pathogenesis of KD-CAT is still being explored, and itstreatment plan and medication has become a research hotspot. This paper reviews the application of KD-CAT from the aspects of traditional Chinese medicine and western medicine. In western medicine the drugs forKD-CAT are divided into antiplatelet, anticoagulant and thrombolytic drugs. In traditional Chinese medicine the drugs for clearing heat and detoxification, supplementing Qi and nourishing Yin, and promoting blood circulationand removing blood stasis are used as the main line of treatment, and it is emphasized that the prescription of "promoting blood circulation and removing blood stasis" must be used throughout the whole process of KD-CAT treatment.

Key words: Kawasaki disease, Coronary artery thrombosis, Western medicine, Traditional Chinese medicine, Progress