ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (4): 353-.

• 小儿中药应用研究 • 上一篇    下一篇

小青龙汤加味治疗急性发作期外寒内饮型小儿支气管哮喘的临床研究

目的: 探究小青龙汤加味治疗急性发作期外寒内饮型小儿支气管哮喘的临床疗效。
方法: 2019年2月至2020年8月我院门诊收治的外寒内饮型支气管哮喘患儿80例，随机分为观察组和对照组各40例，对照组给予常规西药治疗，观察组在对照组基础上服用中药小青龙汤加味，并且激素用量减半，治疗1周后比较两组临床疗效，并对其治疗前后中医证候总积分、肺功能一秒钟呼气流量占预计值百分比即FEV1%、第1秒用力呼气容积与用力肺活量比值（FEV1/FVC）、呼气峰流速（PEF）、呼出气一氧化氮（FeNO）、儿童哮喘控制测试及不良反应情况进行评估。
结果: 治疗后观察组总有效率为92.3%（36/39），高于对照组71.0%（27/38），差异有统计学意义（P<0.05）；治疗后1周后，观察组中医证候总积分明显低于对照组，肺功能明显优于对照组，FeNO的体积分数明显低于对照组，儿童哮喘控制测试优于对照组，差异有统计学意义（P<0.01）；治疗期间两组均无不良反应情况发生。
结论: 在常规西药治疗基础上激素用量减半，应用小青龙汤加味治疗急性发作期外寒内饮型小儿支气管哮喘疗效确切，值得临床进一步推广使用。   

  1. 518100 广东 深圳，北京中医药大学深圳医院（龙岗）儿科（万军，于宙，谭映辉，杨祥正）；100029 北京，北京中医药大学中医学院（杨泽一）
  • 出版日期:2021-08-25 上线日期:2021-12-13
  • 通讯作者: 杨祥正，E-mail:1621912766@qq.com
  • 作者简介:万军（1988-），男，医学硕士，主治医师。研究方向：中西医防治儿童过敏性疾病
  • 基金资助:
    深圳市龙岗区医疗卫生科技计划项目（LGKCYLWS2020148）

Clinical study of modified Xiaoqinglong decoction in the treatment of children with bronchial asthma of external-coldness and internal-drink type during acute onset

Objective: To study the clinical effect of modified Xiaoqinglong decoction in the treatment of children with bronchial asthma ofexternal-coldness and internal-drink type.#br# Methods: A total of 80 children with bronchial asthma of external-coldness andinternal-drink type were treated in our hospital between February 2019 and August 2020, and they were divided into observation group and control group, with 40 cases in each group. Both groups were treated with conventional western medicine, and the observation group was also treated given modified Xiaoqinglong decoction, and the use of hormone was reduced by a half. After one week of treatment, the clinical effect wascompared between the two groups, and compare the total traditional Chinese syndrome score, FEV1%, FEV1/FVC, PEF andFeNO before and treatment, the childhood asthma control test and the adverse reactions were evaluated.#br# Results: After treatment, the total effective rates of the observation group and the control groupwere 92.3% and 71.0%, respectively, with statistically significant differences between the twogroups(P<0.05). After one week of treatment, the total score of TCM syndromes in the observation group was significantly lower than that of the control group(P<0.01), lung function was significantly better(P<0.05), FeNO was significantly lower than that of the control group, and the control test of asthmain the observation group was better than that in the control group(P<0.01). No adverse reactions occurred in both groups during the treatment.#br# Conclusion: On the basis of conventional western medicine treatment, the dosage of hormone is halved, and Xiaoqinglong decoction can be used to treat children with  bronchial asthma of external-cold and internal-drink type during acute onset, which is effective and worthy of further clinical promotion.   

  1. Shenzhen Hospital of Beijing University of Chinese Medicine (Longgang), Shenzhen 518100, China
  • Published:2021-08-25 Online:2021-12-13

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摘要： 目的: 探究小青龙汤加味治疗急性发作期外寒内饮型小儿支气管哮喘的临床疗效。
方法: 2019年2月至2020年8月我院门诊收治的外寒内饮型支气管哮喘患儿80例，随机分为观察组和对照组各40例，对照组给予常规西药治疗，观察组在对照组基础上服用中药小青龙汤加味，并且激素用量减半，治疗1周后比较两组临床疗效，并对其治疗前后中医证候总积分、肺功能一秒钟呼气流量占预计值百分比即FEV1%、第1秒用力呼气容积与用力肺活量比值（FEV1/FVC）、呼气峰流速（PEF）、呼出气一氧化氮（FeNO）、儿童哮喘控制测试及不良反应情况进行评估。
结果: 治疗后观察组总有效率为92.3%（36/39），高于对照组71.0%（27/38），差异有统计学意义（P<0.05）；治疗后1周后，观察组中医证候总积分明显低于对照组，肺功能明显优于对照组，FeNO的体积分数明显低于对照组，儿童哮喘控制测试优于对照组，差异有统计学意义（P<0.01）；治疗期间两组均无不良反应情况发生。
结论: 在常规西药治疗基础上激素用量减半，应用小青龙汤加味治疗急性发作期外寒内饮型小儿支气管哮喘疗效确切，值得临床进一步推广使用。

关键词: 支气管哮喘, 急性发作期, 小青龙汤, 外寒内饮证, 儿童

Abstract: Objective: To study the clinical effect of modified Xiaoqinglong decoction in the treatment of children with bronchial asthma ofexternal-coldness and internal-drink type.
Methods: A total of 80 children with bronchial asthma of external-coldness andinternal-drink type were treated in our hospital between February 2019 and August 2020, and they were divided into observation group and control group, with 40 cases in each group. Both groups were treated with conventional western medicine, and the observation group was also treated given modified Xiaoqinglong decoction, and the use of hormone was reduced by a half. After one week of treatment, the clinical effect wascompared between the two groups, and compare the total traditional Chinese syndrome score, FEV1%, FEV1/FVC, PEF andFeNO before and treatment, the childhood asthma control test and the adverse reactions were evaluated.
Results: After treatment, the total effective rates of the observation group and the control groupwere 92.3% and 71.0%, respectively, with statistically significant differences between the twogroups(P<0.05). After one week of treatment, the total score of TCM syndromes in the observation group was significantly lower than that of the control group(P<0.01), lung function was significantly better(P<0.05), FeNO was significantly lower than that of the control group, and the control test of asthmain the observation group was better than that in the control group(P<0.01). No adverse reactions occurred in both groups during the treatment.
Conclusion: On the basis of conventional western medicine treatment, the dosage of hormone is halved, and Xiaoqinglong decoction can be used to treat children with  bronchial asthma of external-cold and internal-drink type during acute onset, which is effective and worthy of further clinical promotion.

Key words: Bronchial asthma, Acute onset, Xiaoqinglong decoction, External-cold and internal-drink syndrome；Children