ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2023, Vol. 15 ›› Issue (2): 93-98.

• 儿童过敏性紫癜治疗专栏 •    下一篇

秦曼教授治疗小儿过敏性紫癜用药规律的数据挖掘研究

  

  • 出版日期:2023-04-25 上线日期:2023-11-22

Discussion on the medication rules of Professor Qin Man in the treatment of infantile Henoch-Schnlein purpura based on data mining technology

  • Published:2023-04-25 Online:2023-11-22

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摘要： 目的 研究探讨秦曼教授治疗小儿过敏性紫癜(HSP)的处方应用规律，探究核心药物组合的潜在规律，为后续HSP的临床研究提供依据及参考。方法 收集2020年6月至2021年10月在黑龙江省中医药科学院儿科门诊经秦曼教授治疗的HSP临床处方，对其进行筛查整理建立数据库，采用关联规则、复杂网络分析、聚类分析等方法进行数据挖掘和可视化分析，总结药物的应用频次、药对组合。结果 数据库筛选所得有效处方82首，涉及中药101味，频率频次分析中前十位的中药分别为：金银花、甘草、黄芩、白术、茯苓、蝉蜕、白鲜皮、水牛角、陈皮、小蓟。关联分析使用频次>58次的药对共37对，排前3位者分别为：金银花-黄芩、金银花-甘草、黄芩-甘草。聚类分析得到两个处方：(1)苦参、紫草、焦栀子、荆芥、防风、白鲜皮、水牛角、蝉蜕、陈皮、清半夏、白术、茯苓；(2)金银花、黄芩、小蓟、白茅根、仙鹤草。结论 秦曼教授治疗HSP辨病与辨证相结合，治法上主以清热凉血消斑，兼以清热燥湿、健脾益气，其治法与用药规律为中医药治疗HSP的后续研究提供了思路。

关键词: 过敏性紫癜, 中医药, 数据挖掘, 用药规律

Abstract: ObjectiveTo explore the prescription application rule of Professor Qin Man in the treatment of Henoch-Schonlein purpura(HSP) in children, and to explore the potential rule of core drug combination, so as to provide evidence and reference for subsequent clinical research of HSP.MethodsThe clinical prescriptions of Henoch-Schonlein purpura treated by Professor Qin Man in the Pediatrics Clinic of Heilongjiang Academy of Traditional Chinese Medicine from June 2020 to October 2021 were collected and screened to establish a database. Data mining and visual analysis were carried out by using the methods of association rules, complex network analysis and cluster analysis, and the application frequency and combination of drugs were summarized.ResultsTotally 82 valid prescriptions were screened out in the database, involving 101 traditional Chinese medicines. The top ten prescriptions in frequency analysis were honeysuckle, licorice, Scutellaria baicalensis, Atractylodes macrocephala, Poria cocos, cicada slough,Dictamnus dasycarpus, buffalo horn, tangerine peel and field thistle. In association analysis, 37 pairs were used more than 58 times, and the top 3 pairs were honeysuckle-Scutellaria baicalensis, honeysuckle-licorice, Scutellaria baicalensis-licorice. Two prescriptions were obtained by cluster analysis: (1)Sophora flavescens, purple grass, Fructus Gardeniae Praeparatus, Schizonepeta tenuifolia, Saposhnikovia divaricata, Dictamnus dasycarpus, buffalo horn, cicada slough, tangerine peel, Pinellia ternata, Atractylodes macrocephala and Poria cocos. (2)Honeysuckle, Scutellaria baicalensis, field thistle, cogon rhizome and Agrimonia pilosa.ConclusionProfessor Qin Man combines disease differentiation with syndrome differentiation in the treatment of HSP. The main method of treatment is to clear heat, cool blood and eliminate spots, as well as to clear heat and dryness, invigorate spleen and tonify qi. Prof. Qin Man's treatment and medication rules provide ideas for the subsequent study of traditional Chinese medicine in the treatment of Henoch-Schonlein purpura.

Key words:

Henoch-Schnlein purpura, Traditional Chinese medicine, Data mining, Medication rule