ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2023, Vol. 15 ›› Issue (2): 105-109.

• 临床论著 • 上一篇    下一篇

长疗程使用枸橼酸咖啡因对极低出生体重儿安全性的影响

  

  • 出版日期:2023-04-25 上线日期:2023-11-22

Effect of long-term use of caffeine citrate on the safety of very-low-birth-weight infants

  • Published:2023-04-25 Online:2023-11-22

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摘要： 目的 研究长疗程枸橼酸咖啡因的使用对极低出生体重儿安全性的影响。方法 通过对2020年12月至2022年12月我院早产儿重症监护室收治的使用枸橼酸咖啡因治疗的192例极低出生体重儿临床资料进行探讨分析，根据治疗总时间不同分成长疗程组(咖啡因用药至纠正胎龄>34周)107例和常规疗程组(咖啡因用药至纠正胎龄33～34周)85例，比较两组早产儿的临床资料。结果 长疗程组和常规疗程组患儿在性别、入院日龄、多胎妊娠、胎膜早破、剖宫产、产前使用糖皮质激素及产前使用硫酸镁比较差异均无统计学意义(P>0.05),长疗程组在出生体质量、胎龄方面均低于常规疗程组，差异均有统计学意义(P<0.05)。长疗程组咖啡因应用总时间、停药纠正胎龄、改口服纠正胎龄、改口服奶量均高于常规疗程组，差异均有统计学意义(P<0.05)。不良反应方面两组喂养不耐受、高血糖发生率比较差异均无统计学意义(P>0.05)。长疗程组支气管肺发育不良的发生率相对较高，差异有统计学意义(P<0.05)。结论 针对胎龄越小，出生体质量越轻的极低出生体重儿，长疗程使用咖啡因至纠正胎龄36周无明显不良反应发..

关键词: 早产儿呼吸暂停, 枸橼酸咖啡因, 极低出生体重儿

Abstract: ObjectiveTo study the impact of long-term use of caffeine citrate on the safety of very-low-birth-weight infants.MethodsThe clinical data of 192 very-low-birth-weight infants treated with caffeine citrate in our hospital from December 2020 to December 2022 were discussed and analyzed.According to the total time of treatment,the infants were divided into long treatment group and routine treatment group:107 cases in the long treatment group (caffeine was used till corrected gestational age > 34 weeks) and 85 cases in conventional treatment group (caffeine was used till corrected gestational age 33 to 34 weeks).The clinical data of premature infants were compared between the two groups.ResultsThere was no significant difference in sex,age of admission,multiple pregnancy,premature rupture of membranes,cesarean section,prenatal use of glucocorticoid or prenatal use of magnesium sulfate between the long treatment group and the routine treatment group(P>0.05).The birth weight and gestational age in the long treatment group were significantly lower than those in the routine treatment group(P<0.05).The total time of caffeine application, corrected gestational age on stopping medication, corrected gestational age on oral correction and oral milk volume in the long treatment group were higher than those in the conventional treatment group,and there were significant differences between the two groups(P<0.05).There was no significant difference in the incidence of feeding intolerance or hyperglycemia(P>0.05).The incidence of broncho-pulmonary dysplasia in the long treatment group is relatively high,and the differences were statistically significant(P<0.05).ConclusionFor very-low-birth-weight infants with smaller gestational age and lower birth weight,there is no obvious adverse reaction after long-term use of caffeine until the corrected gestational age of 36 weeks,and the safety is high.For children with feeding tolerance,oral caffeine can be used at a proper time.

Key words:

Apnea of prematurity；Caffeine citrate, Very-low-birth-weight infants