ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2023, Vol. 15 ›› Issue (2): 109-115.

• 综述 • 上一篇    下一篇

变应原特异性免疫治疗在儿童过敏性疾病中应用的研究进展

  

  • 出版日期:2023-04-25 上线日期:2023-11-22

Research progress in the application of allergen-specific immunotherapy for children with allergic diseases

  • Published:2023-04-25 Online:2023-11-22

摘要: 变应原特异性免疫治疗(AIT)是一种针对IgE介导的过敏性疾病的脱敏疗法,治疗无法规避过敏原的过敏性疾病,是目前唯一针对过敏性疾病病因控制其发展进程的治疗手段,可获得长期疗效。AIT能够通过诱导机体对特异性变应原产生免疫耐受来达到治疗目的,但其也存在着诸多限制因素。虽然AIT已有百余年的历史,但在儿童过敏性疾病临床应用的研究尚待深入,现就AIT在儿童过敏性疾病的作用机制、临床应用及前景展望进行综述。

关键词: 过敏性疾病, 特异性免疫治疗, 机制, 应用, 儿童

Abstract: Allergen-specific immunotherapy(AIT) is a desensitization therapy for IgE-mediated allergic diseases that can not avoid allergens. At present, it is the only way to control the process of allergic diseases according to the etiology, which can achieve long-term effect. AIT can achieve therapeutic purposes by inducing the body to develop immune tolerance to specific allergens, but there are also many constraints. Although allergen-specific immunotherapy has a history of more than one hundred years, its clinical application in children's allergic diseases has yet to be deepened. This paper aims to review the mechanism, clinical application and prospect of allergen-specific immunotherapy in children's allergic diseases.

Key words:

Allergic diseases, Allergen-specific immunotherapy, Mechanism, Application, Child