ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2023, Vol. 15 ›› Issue (1): 46-52.doi: 10.3969/j.issn.1674-3865.2023.01.010

• 小儿中药应用研究 • 上一篇    下一篇

中医药内外合治法治疗小儿病毒性肺炎有效性的Meta分析

孙嘉忆, 王雪峰, 张秀英, 穆婧雯,    

  1. 110032 沈阳，辽宁中医药大学2021级中医儿科学专业研究生（孙嘉忆，穆婧雯）；辽宁中医药大学附属医院儿科（王雪峰，张秀英）

  • 收稿日期:2022-06-27 出版日期:2023-02-25 上线日期:2023-11-22
  • 通讯作者: 王雪峰，E-mail：lnzywxf@163.com
  • 基金资助:
    国家中医临床研究基地儿科基地，国家“十二五”中医药科研行业专项项目（JDZX2015030）；小儿肺炎传承协同创新平台（2020-1）

Meta-analysis of the effectiveness of the combined method of internal and external Chinese medicine in the treatment of pediatric viral pneumonia

SUN Jiayi, WANG Xuefeng, ZHANG Xiuying, MU Jingwen.   

  1. Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China

  • Received:2022-06-27 Published:2023-02-25 Online:2023-11-22
  • Contact: WANG Xuefeng，E-mail：lnzywxf@163.com

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摘要： 目的 系统评价中医药内外合治综合法治疗小儿病毒性肺炎的临床有效性。方法 在CNKI、VIP、CBM、Wanfang四大中文库以及PubMed、EMBASE、Cochrane library数据库中检索中医药内外合治小儿病毒性肺炎相关的随机对照试验，时限均为建库至2022年5月。经Endnote X9软件去重，筛选文献并提取数据，进行质量评价。采用RevMan5.4软件对数据进行Meta分析。结果 共纳入5篇文献，总样本量为860例。Meta分析结果显示，与对照组相比，内外合治法治疗儿童病毒性肺炎总有效率明显高于对照组([OR=6.17,95%CI(3.50,10.86)],P<0.000 01)。肺啰音消失时间[MD=-2.07,95%CI(-2.99,-1.15),P<0.000 1],喘憋消失时间[MD=-1.17,95%CI(-2.11,-0.24),P=0.01],咳嗽消失时间[MD=-2.11,95%CI(-3.83,-0.39),P=0.02],咳痰消失时间[MD=-1.89,95%CI(-2.33,-1.44),P<0.000 01],结果均显示内外合治法组效果优于对照组。结论 运用内外合治综合疗法治疗小儿病毒性肺炎总体疗效优势显著，对于缩短肺部啰音消失时间、喘憋时间及咳嗽、咳痰消失时间效果明显。 

关键词: 小儿病毒性肺炎, 中医药, 内外合治, Meta分析

Abstract: Objective To systematically evaluate the clinical effectiveness of the combined method of internal and external Chinese medicine in the treatment of pediatric viral pneumonia. Methods The random controlled trials related to the combined internal and external treatment of Chinese medicine for pediatric viral pneumonia were searched in four major Chinese databases, CNKI, VIP, CBM and Wanfang, as well as in PubMed, EMBASE and Cochrane library databases, all with a time period from their establishment to May 2022. The literature was de-duplicated by Endnote X9 software and screened, and data was extracted for quality evaluation. Meta-analysis of the data was performed using RevMan 5.4 software. Results A total of 5 papers with a total sample size of 860 cases were included.Meta-analysis showed that the overall effectiveness of the combined internal and external treatment for childhood viral pneumonia was significantly higher than that of the control group［OR=6.17,95%CI(3.50, 10.86)］(P<0.000 01).The time to disappearance of pulmonary rales［MD=-2.07,95%CI(-2.99,-1.15), P<0.000 1］, time to disappearance of wheezing［MD=-1.17,95%CI(-2.11,-0.24),P=0.01］, time to disappearance of cough［MD=-2.11,95%CI(-3.83,-0.39),P=0.02］ and time to disappearance of cough［MD=-1.89,95%CI(-2.33,-1.44),P<0.000 01］ were all better in the combined internal and external treatment method group than in the control group. Conclusion The overall efficacy of combined internal and external treatment for pediatric viral pneumonia has significant advantages and is effective in shortening the time to disappearance of pulmonary rales, wheezing and cough and sputum.


Key words:

Pediatric viral pneumonia, Chinese medicine, Combined internal and external treatment, Meta-analysis