ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2023, Vol. 15 ›› Issue (1): 52-55.

• 小儿中药应用研究 • 上一篇    下一篇

健脾化痰通络方治疗女童单纯性乳房发育50例临床观察

  

  • 出版日期:2023-02-25 上线日期:2023-11-22

Clinical observation of 50 cases of premature thelarche in girls treated with Jianpi Huatan Tongluo recipe

  • Published:2023-02-25 Online:2023-11-22

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摘要： 目的 评价健脾化痰通络方治疗女童单纯性乳房发育的临床疗效与安全性。方法 回顾性分析2019年6月至2022年1月就诊于苏州市中医医院儿科生长发育专科门诊，诊断为单纯性乳房发育的女童90例，其中观察组50例予健脾化痰通络方干预治疗，对照组40例予临床随访，对比观察组和对照组的临床结局，并对健脾化痰通络方进行疗效与安全性评价。结果 与对照组相比，观察组采用健脾化痰通络方干预随访期间有4例发展为中枢性性早熟，对照组有7例转化为中枢性性早熟；观察组经过治疗后，临床症状及体征均有改善，卵巢容积较治疗前有下降趋势(P<0.05),血清雌二醇与促黄体生成素呈现下降趋势(P<0.05),血清卵泡刺激素差异无统计学意义(P>0.05);观察组在改善中医证候积分方面优势明显，并且未观察到明显的不良反应。结论 采用健脾化痰通络方治疗女童单纯性乳房发育确有临床疗效，值得临床推广应用。

关键词: 单纯性乳房发育, 女童, 健脾化痰通络方

Abstract: ObjectiveTo evaluate the clinical efficacy and safety of Jianpi Huatan Tongluo recipe in the treatment of premature thelarche in girls.MethodsA retrospective analysis was made in 90 girls who were diagnosed with premature thelarche in the pediatric growth and development clinic of our hospital from June 2019 to January 2022.Among them，50 cases in the treatment group were treated with Jianpi Huatan Tongluo recipe; 40 cases in the control group were given clinical follow-up.The clinical outcomes of the treatment group and the control group were compared，and the efficacy and safety of Jianpi Huatan Tongluo recipe were evaluated.ResultsCompared with the control group，4 cases in the treatment group developed into central precocious puberty during the treatment with Jianpi Huatan Tongluo recipe and the follow-up，and 7 cases in the control group developed into central precocious puberty. After treatment，the clinical symptoms and signs of the treatment group were improved，the ovarian volume had a trend of decrease compared with that before treatment（P＜0.05），and the serum estradiol and luteinizing hormone showed a trend of decrease（P＜0.05），while the serum follicle stimulating hormone had no significant difference (P＞0.05). The treatment group had obvious advantages in improving TCM syndrome scores，and no obvious adverse reactions were observed.ConclusionThe use of Jianpi Huatan Tongluo recipe in the treatment of premature thelarche in girls is clinically effective，and it is worthy of clinical application.

Key words:

Premature thelarche, Girl, Jianpi Huatan Tongluo recipe