ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2023, Vol. 15 ›› Issue (1): 56-60.

• 小儿中药应用研究 • 上一篇    下一篇

基于数据挖掘研究名老中医王伯岳治疗儿科疾病用药规律

  

  • 出版日期:2023-02-25 上线日期:2023-11-22

Research on the prescription rules of prestigious Chinese physician Wang Boyue in the treatment of pediatric diseases based on data mining

  • Published:2023-02-25 Online:2023-11-22

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摘要： 目的 探究名老中医王伯岳治疗儿科疾病的处方用药特色及规律。方法 从《王伯岳医学全集》中手工检索收录的方剂包括医案中有完整用药信息的方剂，提取方药信息后参考“十三五”规划教材《中药学》和2015版《中华人民共和国药典》进行数据规范化经双人核对录入Microsoft Excel软件建立“王伯岳儿科用药数据库”,运用频数分析方法统计药物的四气、五味、归经及药物分类，使用SPSS Statistic 25.0软件进行系统聚类分析，使用SPSS Modeler 14.1的Apriori模块进行关联规则及复杂网络分析。结果 共纳入247个方剂，总计235味药，使用中药频次共2 519次，使用频数≥20次的药物33味，贡献百分比为55%,清热药、补气药使用频率较高；药性以“寒性”药物(42.4%)为主，归“肺经”(66%),“胃经”(48%),“脾经”(46%)药物占多数，药味以“甘味”(60.5%)药物为主。关联规则及聚类分析结果提示，王伯岳善于治疗小儿肺系疾病，善于使用伤寒论的经典方剂治疗小儿疾病，常使用“三拗汤”“麻杏石甘汤”“桔梗甘草汤”“白虎汤”“银翘散”加减治疗。治疗过程中尤重调理脾胃，通过调节脾胃气机升降，理湿和胃，消食导滞，健脾助运等全方位对小儿脾胃进行综合调理，用药善于配伍甘草调理五脏六腑之邪气，兼以悦脾。结论 王伯岳治疗儿科疾病，善用伤寒类方，注重调理小儿脾胃，用药上喜用“甘味”药物，以清热药及补虚药应用较多，用药归“肺、脾、胃”经为主。 

关键词: 用药特色, 儿科, 王伯岳, 数据挖掘, 系统

Abstract: ObjectiveTo explore the characteristics and rules of drugs prescribed by prestigious Chinese physician Wang Boyue in the treatment of pediatric diseases.MethodsThe prescriptions included in the "Wang Boyue Medical Complete Collection" were manually retrieved, including those with complete medication information in the medical records. After extracting the prescription information and by referring to the Thirteenth Five-Year Plan textbook "Chinese Materia Medica" and "The Pharmacopoeia of the People's Republic of China (2015 edition), data standardization was performed, and the data was entered into Microsoft Excel software after being checked by two people to establish the "Wang Boyue Pediatric Drug Database". The frequency analysis method was used to count the "four qi", "five flavors", "functioning meridians" and classification of drugs. SPSS Statistic 25.0 software was used to make systematic clustering analysis. SPSS Modeler 14.1 Apriori module was used for association rules and complex network analysis.ResultsA total of 247 prescriptions were included, with a total of 235 drugs. The frequency of the use of Chinese drugs was 2 519 times, and there were 33 drugs being used more than 20 times each, accounting for 55%. The frequently used drugs were those relieving fever and tonifying qi; the drugs were mainly cold in nature (42.4%), and 66% functioned through lung meridian, 48% through stomach and 46% spleen, which accounted for the most part of drugs. The drugs were mainly sweet in flavor (60.5%). Association rules and clustering analysis results showed that Prof. Wang Boyue was good at treating children's pulmonary diseases, and preferred to use the classic prescriptions in the Treatise on Febrile Diseases to treat children's diseases. His commonly used prescriptions included San'ao tablet, Maxing Shigan decoction, Jiegeng Gancao decoction, and Yinqiao powder with addition and subtraction. In the course of treatment, he paid special attention to regulating the spleen and stomach; by regulating the rise and fall of the spleen and stomach qi, regulating dampness and harmonizing stomach, relieving dyspepsia and strengthening spleen and assisting digestion, he comprehensively regulated the spleen and stomach in children.ConclusionProf. Wang Boyue does a good job in using prescriptions for typhoid fever in the treatment of pediatric diseases, pays attention to the conditioning of children's spleen and stomach, and prefers to use "sweet" drugs, heat-clearing drugs and tonifying drugs, which mainly function through the meridians of lung, spleen and stomach.

Key words:

Prescription characteristics, Pediatrics, Wang Boyue, Data mining, Systematic clustering