ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2023, Vol. 15 ›› Issue (1): 71-75.

• 中医应用研究 • 上一篇    下一篇

基于“肺肝同治”理论治疗小儿鼻鼽病肺经伏热证的临床疗效观察

  

  • 出版日期:2023-02-25 上线日期:2023-11-22

Observation of the clinical curative effect in the treatment of children with allergic rhinitis of lung meridian with latent heat based on the theory of "treating both lung and liver"

  • Published:2023-02-25 Online:2023-11-22

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摘要： 目的 通过观察清热通窍汤治疗前后小儿鼻鼽病肺经伏热证症状、体征和血清嗜酸粒细胞(EOS)、鼻腔分泌物EOS变化，客观评价清热通窍汤治疗小儿鼻鼽病临床疗效。方法 在2020年10月至2021年8月贵州中医药大学第二附属医院儿科门诊，招募60例小儿鼻鼽病受试者，并符合肺经伏热证中医辨证分型；采用随机单盲对照方法分为观察组和对照组各30例。观察组予口服清热通窍汤，每日1剂；对照组予口服辛夷鼻炎丸，每日2次，均连服14 d。观察治疗前和治疗后病情，疗程结束后1个月进行随访。结果 对照组在研究过程中脱落1例。(1)观察组总有效率为90.0%(27/30),优于对照组79.3%(23/29),差异有统计学意义(P<0.05)。(2)两组治疗后中医证候总积分低于治疗前，且观察组低于对照组，差异均有统计学意义(P<0.05)。(3)两组治疗后血EOS均低于治疗前，差异有统计学意义(P<0.01)。(4)两组治疗后鼻腔分泌物EOS水平低于治疗前，且观察组低于对照组，差异均有统计学意义(P<0.01)。(5)随访情况：观察组复发20例(66.7%),低于对照组25例(86.2%),差异有统计学意义(P<0.05)。结论 清热通窍汤能明显改善鼻鼽患儿症状，降低鼻腔分泌物EOS水平，抑制鼻高反应、鼻慢性炎症。 

关键词: 变应性鼻炎, 鼻鼽病, 肺经伏热证, 鼻分泌物嗜酸性粒细胞, 儿童

Abstract: ObjectiveBy observing the symptoms，signs，changes of serum eosinophils（EOS） and nasal secretion eosinophils（nasal EOS） before and after treatment with Qingre Tongqiao decoction，the clinical effect of Qingre Tongqiao decoction on children with allergic rhinitis(AR) will be objectively evaluated.MethodsFrom October 2020 to August 2021, in the pediatric outpatient department of the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, 60 children with allergic rhinitis were recruited, who met the TCM syndrome differentiation of lung meridian with latent heat. They were divided into observation group and control group by random single-blind control method, 30 cases in each group. The observation group was given oral Qingre Tongqiao decoction, 1 dose per day; the control group was given Xinyi Biyan pills orally, twice a day; both treatments lasted for 14 days. Observe the condition before and after treatment, and follow up for 1 month after the end of treatment.ResultsIn the control group, 1 case was lost during the study.(1) The total effective rate of the observation group was 90.0%(27/30), which was better than that of the control group(79.3%, 23/29), and the difference was statistically significant(P<0.05).(2)The total scores of TCM syndromes in the two groups after treatment were lower than those before treatment, and the observation group was lower than the control group, the differences being statistically significant(P<0.05). (3) The blood EOS of the two groups after treatment was lower than that before treatment, and the difference was statistically significant(P<0.01).(4) The EOS level of nasal secretions in the two groups after treatment was lower than that before treatment, and the observation group was lower than the control group, the differences being statistically significant(P<0.01).(5)Follow-up: there were 20 cases(66.7%) of recurrence in the observation group,which were lower than 25 cases(86.2%) in the control group, and the difference was statistically significant(P<0.05).ConclusionQingre Tongqiao decoction can significantly improve the symptoms of children with allergic rhinitis, reduce the level of EOS in nasal secretions, and inhibit nasal hyperresponsiveness and chronic nasal inflammation.

Key words:

Allergic rhinitis, Nasal diseases, Syndrome of lung meridian with latent heat, Eosinophil in nasal secretion, Children