ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2022, Vol. 14 ›› Issue (6): 521-524.

• 临床研究 • 上一篇    下一篇

足月窒息新生儿血清鸢尾素和ADAMTS-13水平变化及其对神经功能预后的影响

  

  • 出版日期:2022-12-25 上线日期:2023-11-23

Changes of serum Irisin and Von will brand factor-cleaving protease in full-term asphyxiated newborns and their effects on neurological prognosis

  • Published:2022-12-25 Online:2023-11-23

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摘要：

目的 探讨足月窒息新生儿血清鸢尾素和血管性血友病因子裂解酶(ADAMTS-13)水平变化及其对神经功能预后的影响。方法 选取我院2019年8月至2021年2月收治的足月窒息新生儿87例作为窒息组，同期纳入87例健康新生儿作为对照组。分析两组血清鸢尾素、ADAMTS-13水平变化。所有患儿均随访至3月龄，分析两组神经功能发育与血清鸢尾素、ADAMTS-13的关系。采用Spearman分析血清鸢尾素、ADAMTS-13与新生儿神经行为(NBNA)评分的关系；绘制ROC曲线图分析相关指标对足月窒息新生儿不良预后的预测效能。结果 窒息组血清鸢尾素、ADAMTS-13水平均低于对照组(P<0.05);神经发育落后组血清鸢尾素、ADAMTS-13水平均低于神经发育良好组(P<0.05);经Spearman分析发现，血清鸢尾素与ADAMTS-13呈正相关关系(r=0.447、P=0.000);血清鸢尾素、ADAMTS-13与NBNA均呈正相关关系(r=0.557、0.513,P<0.05);ROC曲线分析发现，二者联合预测患儿神经功能预后的AUC为0.910(0.844～0.978),分别高于血清鸢尾素(AUC=0.782)、ADAMTS-13(AUC=0.649)单独预测患儿神经功能预后的AUC(P<0.05)。结论 足月窒息新生儿血清鸢尾素和ADAMTS-13水平均下降，与足月窒息新生儿神经功能近期预后密切相关。血清鸢尾素和ADAMTS-13对足月窒息新生儿近期神经功能预后具有一定价值。

关键词: 窒息, 新生儿, 血清鸢尾素, 血管性血友病因子裂解酶, 神经功能

Abstract: ObjectiveTo investigate the changes of serum Irisin and Von will brand factor-cleaving protease（ADAMTS-13） levels in full-term asphyxiated newborns and their effects on the prognosis of neurological function.MethodsTotally 87 full-term asphyxia newborns treated in our hospital from August 2019 to February 2021 were selected as the asphyxia group（n=87）;87 healthy newborns were included in the same period as the control group（n=87）.The changes of serum Irisin and ADAMTS-13 levels in different groups were analyzed. All children were followed up to 3 months old to analyze the relationship between neurological development and serum Irisin and ADAMTS-13 in the two groups. Spearman was used to analyze the relationship between serum Irisin，ADAMTS-13 and NBNA score. The ROC curve was drawn to analyze the predictive efficacy 

Key words:

Suffocation, Newborn, Serum irisin, Von will brand factor-cleaving protease, Nerve function