关键词: 窒息, 新生儿, 血清鸢尾素, 血管性血友病因子裂解酶, 神经功能

Abstract: ObjectiveTo investigate the changes of serum Irisin and Von will brand factor-cleaving protease（ADAMTS-13） levels in full-term asphyxiated newborns and their effects on the prognosis of neurological function. Methods Totally 87 full-term asphyxia newborns treated in our hospital from August 2019 to February 2021 were selected as the asphyxia group（n=87）;87 healthy newborns were included in the same period as the control group（n=87）.The changes of serum Irisin and ADAMTS-13 levels in different groups were analyzed. All children were followed up to 3 months old to analyze the relationship between neurological development and serum Irisin and ADAMTS-13 in the two groups. Spearman was used to analyze the relationship between serum Irisin，ADAMTS-13 and NBNA score. The ROC curve was drawn to analyze the predictive efficacy of relevant indicators on the adverse prognosis of full-term asphyxia newborns. Results The levels of serum Irisin and ADAMTS-13 in asphyxia group were lower than those in control group（P＜0.05）,and they were lower in neurodevelopmental retardation group then in the good neurodevelopment group（P＜0.05）.Spearman analysis showed that there was a positive correlation between serum Irisin and ADAMTS-13（r=0.447，P=0.000）.There was a positive correlation between serum Irisin，ADAMTS-13 and NBNA（r=0.557，0.513，P＜0.05）.ROC curve analysis showed that the AUC of the combined prediction of neurological prognosis was 0.910（0.844-0.978），which was higher than that of serum Irisin（AUC=0.782） and ADAMTS-13（AUC=0.649） alone（P＜0.05）. Conclusion The short-term prognosis of neonatal asphyxia in the full-term is closely related to the serum level of Irisin and ADAMTS-13,which are lower.Serum irisin and ADAMTS-13 have certain value in the short-term neurological prognosis of full-term asphyxia newborns.

Key words:

Suffocation, Newborn, Serum irisin, Von will brand factor-cleaving protease, Nerve function