ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2022, Vol. 14 ›› Issue (5): 375-380.

• 小儿呼吸系统疾病Meta分析专栏 • 上一篇    下一篇

中药复方治疗儿童流行性感冒疗效与安全性的Meta分析及试验序贯分析

  

  • 出版日期:2022-10-25 上线日期:2023-11-24

Efficacy and safety of traditional Chinese herbal compound in the treatment of children with influenza

  • Published:2022-10-25 Online:2023-11-24

PDF (PC)

6

摘要： 目的 通过Meta分析方法探讨热毒宁注射液在小儿病毒性肺炎治疗过程中的有效性与安全性。方法 检索在中国知网、维普数据库、万方数据库、中国生物医学文献服务系统、PubMed、Embase数据库中检索有关热毒宁及小儿病毒性肺炎相关的文献，检索时限均为从建库至2021年9月。通过Endnote X9软件去重排除重复文献，根据纳排标准筛选文献，提取数据，质量评价。采用Stata 15.1软件对数据进行记录和Meta分析。最后采用敏感性分析评估结果可靠性。采用漏斗图评价文献的发表偏倚情况。结果 共纳入21篇文献，研究总样本量为2 632。Meta分析后结果显示，试验组的有效率明显高于对照组，差异有统计学意义[RR=1.13,95%CI(1.05,1.21)]。试验组不良反应发生率明显低于对照组，差异有统计学意义[RR=0.43,95%CI(0.29,0.64)]。咳嗽消失时间[SMD=-2.73,95%CI(-3.45,-2.00)],肺部啰音消失时间[SMD=-1.28,95%CI(-1.40,-1.13)],咽痛消失时间[SMD=-1.26,95%CI(-2.00,-0.52)],X线胸片阴影消失时间[SMD=-2.38,95%CI(-3.38,-0.88)],退热时间[SMD=-2.14,95%CI(-2.85,-1.43)],住院时间[SMD=-1.97,95%CI(-2.79,-1.14)],结果均显示试验组效果优于对照组。结论 热毒宁注射液在治疗小儿病毒性肺炎时疗效显著，在联合使用热毒宁注射液的情况下能够提升有效率并大幅度减少不良反应的发生。 

关键词: 流行性感冒, 中药复方, Meta分析, 试验序贯分析

Abstract: ObjectiveTo systematically evaluate the efficacy and safety of traditional Chinese herbal compound in the treatment of children with influenza.MethodsAll randomized controlled trials on TCM compound in the treatment of pediatric influenza were searched for in CNKI, Wanfang database, VIP, PubMed, Embase and Cochrane Library databases,the retrieval time being from January 2012 to June 2022. Literature screening and data extraction were carried out by two researchers independently, and the quality of the included studies was evaluated. Meta-analysis was conducted by RevMan 5.3 software, and trial sequential analysis was conducted by TSA 0.9.5.10 software.ResultsA total of 11 RCTS were included,involving a total of 3 232 patients. Meta-analysis showed that the total effective rate ［RR=1.25, 95%CI(1.22, 1.30), Z=13.83, P<0.000 01］ was better than the control group,the main symptom relief time was significantly reduced ［MD=-2.62，95%CI(-3.88，-1.36)，Z=4.08，P＜0.000 1］, and the incidence of adverse reactions was lower than that of control group ［RR=0.66, 95%CI(0.47,0.94), Z=2.29, P=0.02］, the differences being statistically significant. TSA results showed that Chinese herbal compound was effective in the treatment of children with influenza, and has reached the expected information value.ConclusionTraditional Chinese medicine compound is effective and safe in the treatment of children influenza, but it needs to be further verified by high-quality studies.

Key words: Influenza, Traditional Chinese medicine compound, Meta analysis, Trial sequential analysis