ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2022, Vol. 14 ›› Issue (5): 381-390.

• 小儿呼吸系统疾病Meta分析专栏 • 上一篇    下一篇

玉屏风颗粒联合常规西药治疗儿童哮喘疗效及安全性的Meta分析

  

  • 出版日期:2022-10-25 上线日期:2023-11-24

Efficacy and safety of Yupingfeng granules combined with conventional western medicine in management of childhood asthma


  • Published:2022-10-25 Online:2023-11-24

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摘要： 目的 系统评价中药复方治疗儿童流行性感冒(简称流感)的疗效与安全性。方法 计算机检索中国知网、万方数据库、维普中文科技期刊数据库、PubMed、Embase和Cochrane library数据库中有关中药复方治疗儿童流感的所有随机对照试验，检索时间为2012年1月至2022年6月。由2名研究者独立地进行文献筛选与资料提取，对纳入研究进行质量评价，采用RevMan 5.3软件进行Meta分析，采用TSA 0.9.5.10软件进行试验序贯分析。结果 共纳入随机对照试验研究11项，共涉及3 232例患者。Meta分析结果显示，中药复方治疗儿童流感的总有效率[RR=1.25,95%CI(1.22,1.30),Z=13.83,P<0.000 01]优于对照组，主要症状缓解时间较对照组明显减少[MD=-2.62,95%CI(-3.88,-1.36),Z=4.08,P<0.000 1],且不良反应发生率低于对照组[RR=0.66,95%CI(0.47,0.94),Z=2.29,P=0.02],差异均有统计学意义。试验序贯分析结果显示中药复方治疗儿童流感确有疗效，证据可靠，且已达到期望信息值。结论 中药复方治疗儿童流感疗效确切且安全性较高，但尚需高质量的研究进一步验证。 

关键词: 哮喘, 玉屏风颗粒, 急性发作期, 缓解期, 儿童

Abstract: ObjectiveTo systematically evaluate the efficacy and safety of Yupingfeng granules combined with conventional western medicine for acute exacerbation and remission of childhood asthma.MethodsThe databases of CNKI, Wanfang, VIP, CMB, Chinese Medical Journal Network, PubMed, Cochrane Library and Embase were searched for randomized controlled trials on the effect of Yupingfeng granules in management of childhood asthma. RevMan 5.4.1 was used to perform a Meta analysis.ResultsA total of 23 studies were included, with 1 147 subjects in acute exacerbation stage and 1 897 subjects in remission stage. The Meta analysis showed that compared with the control group, Yupingfeng granules significantly improved the effective rate in acute exacerbation(RR=1.24,P<0.001), and shortened duration of cough(MD=1.25,P<0.001),wheezing(MD=1.46,P<0.001) and pulmonary wheezing on auscultation(MD=1.39,P<0.001). For asthmatic children in remission stage, Yupingfeng granules significantly improved the effective rate(RR=1.22, P<0.001), reduced the number of acute exacerbation(MD=1.62,P<0.001) and respiratory infections(MD=3.19,P<0.001) and time of antibiotic use(MD=1.09,P<0.001), and significantly improved lung function, cellular immunity and humoral immunity(P<0.05). Yupingfeng granules significantly down-regulated IL-4, IL-9 and IL-17 levels(P<0.05), and up-regulated IFN-γ level(P<0.05). In addition, the incidence of adverse effect was comparable between the Yupingfeng granules group and the control group(P=0.19).ConclusionYupingfeng granules combined with conventional western medicine can improve management efficacy of childhood asthma in acute exacerbation and remission stage, relieve symptoms of acute exacerbation, and reduce exacerbations during remission stage. Yupingfeng granules can also help to improve lung function, cellular immunity and humoral immunity, reduce inflammatory factors, and has good safety.

Key words:

Asthma, Yupingfeng granules, Acute exacerbation stage, Remission stage；Children