ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2022, Vol. 14 ›› Issue (5): 391-394.

• 综述 • 上一篇    下一篇

链球菌感染与IgA血管炎的相关性研究

  

  • 出版日期:2022-10-25 上线日期:2023-11-24

Correlation between streptococcal infection and IgA vasculitis

  • Published:2022-10-25 Online:2023-11-24

摘要: IgA血管炎过去称为过敏性紫癜,是一种白细胞碎裂性血管炎,其发病机制不明。大量研究发现链球菌感染及免疫紊乱可能是导致其发生的原因。文章主要探究可能引起IgA血管炎的链球菌生物膜的结构,如AgⅠ/Ⅱ家族蛋白、脱氧核糖核酸酶、脂壁磷酸酶、胶原样蛋白-1、半胱氨酸蛋白酶等,以及免疫紊乱中的Th1/Th2比例失衡

关键词: IgA血管炎, IgA血管炎肾损害, 链球菌, 生物膜, Th1, Th2, 补体

Abstract: IgA vasculitis used to be called allergic purpura, which is a kind of leucocyte fragmentation vasculitis with unknown pathogenesis. A large number of studies have found that streptococcal infection and immune disorders may be the cause of the disease. This article mainly focuses on the structure of streptococcal biofilms that may cause IgA vasculitis, such as AgⅠ/Ⅱ family proteins, deoxyribonuclease, lipid wall phosphatase, collagen-like protein-1, cysteine protease, etc., and Th1/Th2 ratio imbalance in immune disorders.

Key words:

IgA vasculitis, IgA vasculitis renal injury, Streptococcus, Biofilm, Th1, Th2, Complement