ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2022, Vol. 14 ›› Issue (4): 355-360.

• 小儿中药应用研究 • 上一篇    下一篇

中医药治疗过敏性紫癜湿热证的临床数据挖掘研究

  

  • 出版日期:2022-08-25 上线日期:2023-11-29

Research on clinical data mining of traditional Chinese medicine in the treatment of Henoch-Schnlein purpura damp heat syndrome

  • Published:2022-08-25 Online:2023-11-29

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摘要： 目的 分析湿热型过敏性紫癜的中药处方用药规律。方法 检索中国期刊全文数据库、维普数据库、万方数据库中医药治疗湿热型过敏性紫癜的相关文献，将所得数据进行处理并建立数据库，运用Excel 2019、SPSS modeler 18.0和SPSS statistics 22.0分别进行频次分析、关联规则分析以及聚类分析。结果 共筛选出101个处方，涉及中药159味，高频中药22味，主要有薏苡仁、黄柏、苍术等；药性以寒为主，药味以苦、甘、辛居多，归经主要为肝、肺、脾胃经；关联规则结果显示薏苡仁、黄柏、苍术、牛膝、紫草、牡丹皮、茜草、白茅根等关系密切；聚类分析得到5个聚类方。结论 临床治疗过敏性紫癜湿热证主要针对“湿”“热”“瘀”等病理因素，处方用药体现出“清热利湿与化瘀止血并重”的特点，清热利湿常用“四妙丸”为主方加减，灵活配合“活血化瘀”使湿热去，瘀阻消，正气复来而诸症自和。

关键词:

过敏性紫癜, 数据挖掘, 湿热证, 处方用药规律, 关联规则

Abstract:

ObjectiveTo analyze the law of traditional Chinese medicine prescription for damp-heat allergic purpura.MethodsThe Chinese Journal Full-text database，VIP database and Wanfang database were searched for literature related to Chinese medicine treatment for damp-heat allergic purpura.The data were processed and the database was established.The frequency analysis，association rule analysis and cluster analysis were carried out by using Excel 2019，SPSS modeler 18.0 and SPSS statistics 22.0.ResultsA total of 101 prescriptions were screened，involving 159 Chinese medicines and 22 high-frequency Chinese medicines，mainly including coix seed，Phellodendron amurense and Atractylodes macrocephala.The medicines were mainly cold，and the medicines were mostly bitter，sweet or pungent.The medicines functioned mainly through liver，lung，spleen and stomach meridians.The results of association rules showed that coix seed，Cortex phellodendri，Atractylodes lancea，Achyranthes bidentata，Arnebia，peony bark，madder and white grass root were closely related.Five clusters were obtained by cluster analysis.ConclusionThe clinical treatment for damp heat syndrome of Henoch-Schnlein purpura mainly focus on the pathological factors such as "dampness"，"heat" and "blood stasis".The prescriptions reflect the characteristics of "clearing heat and dampness and removing blood stasis and hemostasis".The "Simiao pill" is commonly used to add and subtract the main formula of clearing heat and dampness，and flexible combination with "activating blood and removing blood stasis" can remove damp heat，eliminate blood stasis and restore healthy qi，and the disease is cured.

Key words:

Allergic purpura, Data mining, Damp heat syndrome, Law of prescription, Association rules