ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2022, Vol. 14 ›› Issue (3): 225-228.

• 临床研究 • 上一篇    下一篇

肺炎支原体肺炎患儿疾病严重程度与维生素D、C反应蛋白及D二聚体水平的关系

  

  • 出版日期:2022-06-25 上线日期:2023-12-01

Relationship between disease severity and levels of vitamin D,C-reactive protein and D-dimer in children with Mycoplasma pneumoniae pneumonia

  • Published:2022-06-25 Online:2023-12-01

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摘要： 目的 探究肺炎支原体肺炎患儿疾病严重程度与维生素D、C反应蛋白(CRP)及D二聚体水平的关系。方法 选取2018年2月至2020年2月我院收治的肺炎支原体肺炎患儿125例，根据患儿临床表现分为重度组(难治性肺炎支原体肺炎)63例和轻度组(普通肺炎支原体肺炎)62例，另同期选取健康儿童41例为对照组。检测患儿活化部分凝血酶原时间(aPTT)、凝血酶原时间(PT)、血小板计数(PLT)、纤维蛋白原(Fbg)、D二聚体水平、CRP、维生素D水平，采用Logistic回归分析维生素D、CRP及D二聚体水平与肺炎支原体肺炎患儿疾病严重程度的关系。结果 3组患儿PT、PLT、Fbg、aPTT水平比较差异无统计学意义(P>0.05),轻度组与重度组D二聚体水平高于对照组，差异有统计学意义(P<0.05)。重度组与轻度组CRP水平高于对照组，维生素D水平低于对照组，差异有统计学意义(P<0.05)。D二聚体和CRP水平与患儿病情严重程度呈正相关，维生素D水平与病情严重程度呈负相关(P<0.05)。结论 D二聚体、CRP、维生素D与肺炎支原体肺炎病情具有明显的相关性，可以作为判断肺炎支原体肺炎病情的指标。

关键词:

肺炎支原体肺炎, 维生素D, C反应蛋白, D二聚体, 儿童

Abstract:

ObjectiveTo explore the relationship between the severity of disease and the levels of vitamin D,C-reactive protein (CRP) and D-dimer in children with Mycoplasma pneumoniae pneumonia.MethodsA total of 125 children with Mycoplasma pneumoniae pneumonia admitted to our hospital from February 2018 to February 2020 were selected.According to the clinical manifestations,the children were divided into severe group (refractory Mycoplasma pneumoniae pneumonia,63 cases) and mild group (common Mycoplasma pneumoniae pneumonia,62 cases),and 41 healthy children were selected as the control group during the same period.Activated partial prothrombin time (aPTT),prothrombin time (PT),platelet count (PLT),fibrinogen (Fbg),D dimer level,CRP and vitamin D level were detected.Logistic regression was used to analyze the relationship between vitamin D,CRP and D dimer levels and disease severity in children with Mycoplasma pneumoniae pneumonia.ResultsThere were no significant differences in PT,PLT,Fbg or aPTT levels among the 3 groups(P>0.05),and the D-dimer level of the mild group and the severe group was higher than that of the control group,the difference being statistically significant(P<0.05).CRP level in severe and mild groups was higher than that in control group,and vitamin D level was lower than that in control group,the differences being statistically significant(P<0.05).D dimer and CRP levels were positively correlated with the severity of the disease,while vitamin D levels were negatively correlated with the severity of the disease(P<0.05).ConclusionD-dimer,CRP and vitamin D have significant correlation with the disease state of Mycoplasma pneumoniae pneumonia,which can be used as indicators to judge the disease state of Mycoplasma pneumoniae pneumonia.

Key words:

Mycoplasma pneumoniae pneumonia, Vitamin D, C-reactive protein, D dimer, Children