关键词:

急性重症病毒性心肌炎, 丙种球蛋白, 心肌酶谱, 免疫功能, 儿童

Abstract:

ObjectiveTo explore the effect of high-dose gamma globulin in the treatment of acute severe viral myocarditis in children.MethodsA total of 94 children with acute severe viral myocarditis admitted to our hospital from January 2016 to January 2021 were included as research subjects,and they were randomly divided into control group and observation group,with 47 in each group.The control group was given conventional treatment,and the observation group was additionally given intravenous infusion of large-dose gamma globulin［400 mg/(kg·d)］,once a day,for 2 consecutive weeks.The total effective rate,myocardial enzyme spectrum and adverse reactions were compared between the two groups.ResultsThe total effective rate in the observation group was 93.62% (44/47),higher than 76.60% (36/47) in the control group,and the difference was statistically significant (P<0.05).The levels of creatine kinase,creatine kinase isoenzyme and lactate dehydrogenase in the observation group were significantly lower than those in the control group (P<0.05).After treatment,CD3+ and CD8+ in the observation group were higher than those in the control group,and CD4+ was lower,the difference being statistically significant (P<0.05).There were no obvious adverse reactions in both groups.ConclusionThe application effect of large dose gamma globulin in the treatment of acute severe viral myocarditis in children is definite,which is helpful to improve the immune function and myocardial enzyme spectrum of children,and promote the early recovery of children,so it is worthy of promotion

Key words:

Acute severe viral myocarditis, Gamma globulin, Myocardial enzyme spectrum, Immune function, Children