关键词:

肥胖, 脾主运化, 肠道菌群, 能量代谢

Abstract:

Based on the theory of spleen governing transportation and transformation, this paper analyzes the correlation between childhood obesity and spleen governing transportation and transformation. The main pathogenesis is in the spleen's inability to transport normally and the internal excess of sputum and dampness evils. The importance of the treatment for obesity by managing spleen is described according to the etiology and pathogenesis of traditional Chinese medicine(TCM), and based on the modern researches on obesity, the relationship of spleen's inability to transport normally with intestinal microflora, mitochondria function and fat metabolism is analyzed to discover the pathogenesis of childhood obesity. The imbalance of intestinal microflora, the damaged function of mitochondria and the disorder of fat metabolism lead to the decreased synthesis of short-chain fatty acids, the disorder of material energy metabolism, the weakened mitochondria function of bone muscle and adipose tissue, the dysfunction of fat transportation and the ectopic fat deposition. The Chinese medicines to invigorate spleen, help transportation and remove dampness can recover the spleen's function in governing transportation and transformation, which helps to regulate the dysfunction of intestinal microflora, recover the function of mitochondria, promote fat metabolism and improve obesity, hence providing new lines of thinking in the clinical prevention and treatment of childhood obesity based on the theory of spleen governing transportation and transformation.

Key words:

Obesity, Spleen governing transportation and transformation, Intestinal microflora, Energy metabolism