ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2022, Vol. 14 ›› Issue (2): 93-100.doi: 10.3969/j.issn.1674-3865.2022.02.001

• 儿童流感病毒感染防治专栏 •    下一篇

中成药治疗儿童流行性感冒的Meta分析

张喜莲, 郦涵, 马融, 闫海虹, 戎萍, 尹贵蕾   

  1. 300193 天津，天津中医药大学第一附属医院儿科，国家中医针灸临床医学研究中心（张喜莲，郦涵，马融，戎萍）；030013 太原，山西省儿童医院中医科（闫海虹）；052360 石家庄，河北省中医院儿科（尹贵蕾）
  • 收稿日期:2022-02-24 出版日期:2022-04-25 上线日期:2023-12-01
  • 通讯作者: 马融，E-mail：mr1974@163.com
  • 基金资助:
    天津市科技计划项目（S18ZC63018）；国家中医药管理局项目（GZY-FJS-2018-216）；中华中医药学会标准化项目（2018年3月）；天津市卫生计生行业高层次人才选拔培养工程项目

Meta-analysis of Chinese patent medicine in the treatment of influenza in children

ZHANG Xilian, LI Han, MA Rong, YAN Haihong, RONG Ping, YIN Guilei   

  1. The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193，China

  • Received:2022-02-24 Published:2022-04-25 Online:2023-12-01
  • Contact: MA Rong，E-mail：mr1974@163.com

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摘要： 目的 通过Meta分析评价中成药治疗儿童流行性感冒的临床疗效及安全性。方法 检索PubMed、Cochrane Library、Embase、中国知网(CNKI)、中国生物医学文献数据库(CBM)、万方(WanFang)和维普(VIP)数据库。由2位研究者依照纳排标准独立进行文献筛选，对符合要求的文献采用Cochrane偏倚风险评估工具对其方法学质量进行评估。提取文献的原始资料，采用Revman 5.3软件进行文献数据整合分析。结果 共纳入51篇中文文献，研究质量均偏低。Meta分析结果：(1)临床疗效方面：中成药单用或联用西药治疗儿童流感的临床总有效率优于西药(P<0.000 01)。(2)安全性方面：口服中成药治疗儿童流感的不良事件发生率与西药相比，差异有统计学意义(P=0.001);中成药注射液治疗儿童流感的不良事件发生率与西药相比，差异无统计学意义(P=0.56)。结论 基于目前的证据，中成药治疗儿童流感疗效确切，口服中成药安全性较好。

关键词:

流行性感冒, 中成药, Meta分析, 儿童

Abstract:

Objective To evaluate the clinical efficacy and safety of Chinese patent medicine in treating influenza in children by meta-analysis.Methods The PubMed, Cochrane Library, Embase, CNKI, CBM, WanFang and VIP databases were searched. Two investigators independently screened the literature according to inclusion and exclusion criteria. The qualified literature reviews were evaluated for its methodological quality by using the Cochrane risk assessment tool. The original data of the literature was extracted and the data integration analysis of the literature was carried out by using Revman 5.3 software.Results A total of 51 Chinese RCTs were included, which were of low research quality. Meta-analysis results showed that: （1）In terms of clinical efficacy, Chinese patent medicine used alone or in combination with western medicine is better than western medicine in the treatment of children with influenza(P＜0.000 01). （2）In terms of safety, there was significant difference in the incidence of adverse events between oral Chinese patent medicine and western medicine(P=0.001)；there was no significant difference in the incidence of adverse events between Chinese patent medicine injection and western medicine(P=0.56).Conclusion Based on the current evidence, it has been proved that Chinese patent medicine is effective in the treatment of childhood influenza, and it is safer in oral medication.

Key words:

Influenza, Chinese patent medicine, Meta-analysis, Child