ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2022, Vol. 14 ›› Issue (2): 131-134.

• 临床研究 • 上一篇    下一篇

小肠细菌过度生长在婴幼儿腹泻中的临床分析

  

  • 出版日期:2022-04-25 上线日期:2023-12-01

Clinical analysis of small intestinal bacteria overgrowth in infancy diarrhea

  • Published:2022-04-25 Online:2023-12-01

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摘要： 目的 研究小肠细菌过度生长(SIBO)在婴幼儿迁延性和慢性腹泻中的患病率，同时分析婴幼儿SIBO的临床特点及治疗转归。方法 回顾性研究2017年4月11日至2019年4月10日我院住院部消化内科收治的迁延性和慢性腹泻婴幼儿110例。应用乳糖氢呼气试验作为SIBO的诊断方法。结果 乳糖氢呼气试验阳性率为9.09%(10例);SIBO阳性患儿与SIBO阴性患儿比较，阳性患儿黏液便少于阴性患儿，差异有统计学意义(P<0.05);大便次数、腹胀、呕吐、哭闹情况、脱水比较差异无统计学意义(P>0.05);阳性患儿贫血发生率、生长迟缓率、乳糖吸收不良发生率均高于阴性患儿，差异有统计学意义(P<0.05);阳性患儿给予益生菌治疗及去乳糖奶粉喂养后，出院时8例症状缓解，1例无明显缓解。结论 SIBO在婴幼儿腹泻中较常见，临床表现无显著特异性，易出现水样便、贫血、生长迟缓、乳糖吸收不良，益生菌治疗及饮食调整有效。

关键词:

迁延性慢性腹泻, 小肠细菌过度生长, 乳糖氢呼气试验, 婴幼儿

Abstract:

ObjectiveTo study the prevalence of small intestinal bacterial overgrowth(SIBO) in infants with persistent and chronic diarrhea, and to analyze the clinical features and treatment outcomes of SIBO in infants.MethodsA retrospective study was made in 110 infants with persistent and chronic diarrhea, who were treated in the Department of Gastroenterology of our hospital from April 11, 2017 to April 10, 2019. The lactose hydrogen breath test was used as a diagnostic method for SIBO.ResultsThe positive rate of lactose hydrogen breath test was 9.09%(10/110) . Comparing the SIBO positive group with SIBO negative group,the mucous stool in positive group was less than that in SIBO negative group,and the difference was statistically significant（P＜0.05）. There was no significant difference in frequency of bowel movement, abdominal distension, vomiting, crying or dehydration（P＞0.05）. The incidence of anemia，growth retardation and lactose malabsorption in the positive group were all higher than those in the negative group,and the difference was statistically significant (P<0.05). After being treated with probiotics and fed with lactose-free milk powder, the symptoms of 8 cases(8/9) were relieved on discharge, while 1 case(1/9) was not significantly relieved.ConclusionSIBO is more common in infancy diarrhea,and its clinical manifestations are not significantly specific.The infants are more likely to have watery stool, anemia, growth retardation and lactose malabsorption.Probiotics and diet adjustment are effective.

Key words:

Persistent and chronic diarrhea, Small intestinal bacterial overgrowth；Lactose hydrogen breath test, Infants