ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2022, Vol. 14 ›› Issue (1): 79-82.

• 小儿中药应用研究 • 上一篇    下一篇

基于数据挖掘探讨过敏性紫癜的组方用药规律

  

  • 出版日期:2022-02-25 上线日期:2023-12-05

Exploring prescription regularity in treating HSP based on clinical data mining

  • Published:2022-02-25 Online:2023-12-05

摘要: 目的 探讨过敏性紫癜(HSP)的组方用药规律。方法 通过对2016年5月至2020年9月山东中医药大学附属医院收治的107例HSP患儿的电子病历进行分析筛选并建立处方数据库,运用频数统计、关联规则和聚类分析(K-means算法+回归模型)进行数据挖掘,借助中医传承辅助系统(V3.0)分析中医药治疗HSP的用药组方规律。对核心药物的频次、性味、归经、功效、核心组合等进行分析研究。结果 分析出使用频次>20次的中药16味,使用高频药物包括:炙甘草、苍术、丹皮、薏苡仁、黄柏、紫草等。使用频次≥30次的药物组合23对,使用高频药对包括:苍术-黄柏、苍术-丹皮-薏苡仁、丹皮-赤芍等。以苦味、甘味药物为主,药性以寒性为主,归经以归肺、脾、肝、心经为主。结论 总结了本院治疗HSP常使用“苦甘合法”“驱除伏邪”等治法,用药以清热解毒、活血化瘀类为主,兼用补益药物。

关键词: 紫癜, 伏邪, 瘀血, 卫气, 中医传承辅助平台

Abstract: ObjectiveTo investigate the prescription regularity in treating HSP.MethodsThe electronic medical records of 107 HSP child patients in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from May 2016 to September 2020 were collected, and were screened and analyzed which were used to build a prescription database. Frequency statistics method, association rules and cluster analysis(K-means algorithm+regression models) were used to process data mining. Analyze the prescription regularity of traditional Chinese medicine in treating HSP with the help of TCMISS(V3.0) The property and flavor, frequency, meridian distribution, effect and core drug combination of the core drugs were studied.ResultsThere were 16 Chinese herbs with frequency of usage≥20, and the herbs with high frequency of usage included: honey-fried licorice root, rhizoma atractylodis, moutan bark, semen coicis, golden cypress, lithospermum, etc. There were 23 herb pairs with frequency of usage≥30,and the herb pairs with high frequency of usage included rhizoma atractylodis-golden cypress,rhizoma atractylodis-moutan bark-semen coicis, moutan bark-radix paeoniae rubra, etc. Main taste was bitter and sweet, main drug property was cold, and the main meridian distribution was in lung, spleen, liver and heart. ConclusionThe treatment methods for HSP in our hospital were summarized, such as "bitter and sweet law" and "dispelling latent evil". The main drugs are to clear away heat and toxic materials and promote blood circulation and remove blood stasis, and tonifying drugs are used at the same time.

Key words: HSP, Latent evil, Blood stasis, Defensive qi;TCMISS