关键词: 川崎病, 冠状动脉损害, C反应蛋白, 血小板计数, 羧化不全骨钙素, 儿童

Abstract: ObjectiveTo investigate the serum C-reactive protein(CRP) level, platelet count(PLT) and undercarboxylated osteocalcin(ucOC) levels in children with Kawasaki disease complicated with coronary artery lesions(CALs) and its significance.MethodsTotally 72 cases(observation group) of children with Kawasaki disease treated in our hospital from September 2017 to September 2019 were selected, and 70 healthy children receiving physical examination during the same period were selected as the control group. The serum CRP, PLT and ucOC levels were detected, and the occurrence of CALs in children with Kawasaki disease was examined by echocardiography.ResultsThe CRP and PLT in the observation group were significantly higher than those in the control group(P<0.05), while ucOC was significantly lower than those in the control group(P<0.05). There were 25 children with CALs by echocardiography. In the observation group, CRP in children with CALs was significantly higher than that in children without CALs(P<0.05), while ucOC was significantly lower(P<0.05). There was no significant difference in PLT between children with and those without CALs in observation group(P>0.05). The area under ROC curve of CRP and ucOC in diagnosing Kawasaki disease with CALs was 0.701 and 0.651(P<0.05).Cut-off values were 74.69 mg/L and 12.36 g/L, the sensitivity was 48.00% and 52.00%, and specificity was 87.23% and 89.36%, respectively.ConclusionCRP, PLT and ucOC levels are increased in children with Kawasaki disease complicated with CALs, among which CRP and ucOC has certain application value in diagnosing Kawasaki disease complicated with CALs.

Key words: Kawasaki , disease, Coronary artery lesion, C-reactive protein, Platelet count, Undercarboxylated osteocalcin, Children