关键词: 抽动障碍, 祛风止动方, 临床疗效, 积分变化, 中医治疗, 儿童

Abstract: ObjectiveTo investigate the clinical efficacy of Qufeng Zhidong prescription in the treatment of children with exogenous wind syndrome of tic disorder. MethodsFrom February 2021 to June 2022 in the pediatric clinic of Yixing Hospital of Traditional Chinese Medicine,80 children diagnosed with exogenous wind syndrome of tic disorder were randomly divided into treatment group and control group,40 cases in each group.The treatment group was treated with Qufeng Zhidong prescription taken orally,while the control group was treated with tiapride hydrochloride taken orally.Both groups were treated for 8 weeks.The total clinical effective rate,changes in TCM syndrome score before and after treatment,changes in tic symptom severity scale score before and after treatment,recurrence rate and adverse reactions were compared between the two groups.ResultsThe total effective rate was 92.5%（37/40） in the treatment group and 75.0%（30/40） in the control group.There was significant difference between the two groups (P<0.05).After 60 days of treatment,the scores of tic severity and TCM clinical syndromes in both groups were lower than those before treatment,and the scores in the treatment group were significantly lower than those in the control group(P<0.05).At the 3-month and 6-month follow-up,there was no statistical difference in the recurrence rate between the two groups(P>0.05).ConclusionQufeng Zhidong prescription has a good clinical effect in the treatment of children exogenous wind syndrome of tic disorder,which can significantly improve the clinical signs and symptoms of children and has high safety,and is worthy of further study.

Key words: Tic disorder, Qufeng Zhidong prescription, Clinical curative effect, Changes in scores, TCM treatment, Children