ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2024, Vol. 16 ›› Issue (1): 31-37.

• 临床研究 • 上一篇    下一篇

麻杏石甘汤联合西药治疗儿童社区获得性肺炎疗效的Meta分析

  

  • 出版日期:2024-02-25 上线日期:2024-03-13

Meta-analysis of the efficacy of Maxing Shigan decoction combined with western medicine in the treatment of community-acquired pneumonia in children

  • Published:2024-02-25 Online:2024-03-13

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摘要： 目的 系统评价麻杏石甘汤联合西医常规治疗儿童肺炎的疗效及安全性。方法 计算机检索国内外各数据库自建库至2023年8月1日所发表的联用麻杏石甘汤治疗儿童肺炎的随机对照试验，2名研究者单独进行文献筛选与资料提取，并对纳入研究进行质量评价，采用RevMan 5.3软件进行Meta分析。结果 共纳入9项研究，共涉及1 005例患者，其中试验组504例，对照组501例。Meta分析结果表明联用麻杏石甘汤治疗小儿肺炎的总有效率[RR=1.16,95%CI(1.11,1.22),P<0.000 01]、咳嗽消失时间[SMD=-1.60,95%CI(-1.81,-1.39),P<0.000 01]、退热时间[SMD=-1.43,95%CI(-2.04,-0.82),P<0.000 01]、肺部啰音消失时间[SMD=-1.35,95%CI(-1.55,-1.15),P<0.000 01]、治疗后血清C反应蛋白水平均优于对照组，不良反应及并发症发生情况优于对照组[RR=0.41,95%CI(0.18,0.95),P=0.04]。结论 麻杏石甘汤联合西医常规治疗儿童肺炎疗效确切，安全性优于西医常规治疗，但尚需高质量随机对照试验研究进一步验证。

关键词: 社区获得性肺炎, 麻杏石甘汤, Meta分析, 儿童

Abstract: ObjectiveTo systematically evaluate the efficacy and safety of Maxing Shigan decoction combined withconventional western medicine in the treatment of pneumonia in children.MethodsRandomized controlled trials of combined use of Maxing Shigan decoction in the treatment of childhood pneumonia were searched by computer in the databases at home and abroad, which were published from the establishment of databases to August 1, 2023. Two researchers conducted literature screening and data extraction separately, and the quality of the included studies was evaluated. Meta-analysis was performed using RevMan 5.3 software.ResultsA total of 9 studies were included, involving a total of 1 005 patients, including 504 patients in the experimental group and 501 patients in the control group. The results of Meta-analysis showed that the total effective rate of combined use of Maxing Shigan decoction in the treatment of children with pneumonia［RR＝1.16，95%CI（1.11,1.22）,P<0.000 01］, the time of cough disappearance［SMD=-1.60,95%CI (-1.81,-1.39),P<0.000 01］, fever relief time［SMD=-1.43,95%CI (-2.04,-0.82),P<0.000 01］, lung rale disappearance time［SMD＝-1.35,95%CI（-1.55,-1.15）,P<0.000 01］, and the levels of serum CRP after treatment in the experimental group were better than those of control group, and the incidence of adverse reactions and complications was better than that of control group［RR=0.41,95%CI(0.18,0.95)，P=0.04］.ConclusionMaxing Shigan decoction combined with conventional western medicine is effective, and is also safer than conventional western medicine in the treatment of children with pneumonia, but high-quality RCT studies are needed for further verification. 

Key words:

Community-acquired pneumonia, Maxing Shigan decoction, Meta-analysis, Children