基于国家专利的中药复方治疗湿疹及特应性皮炎用药规律研究

中国中西医结合儿科学 ›› 2024, Vol. 16 ›› Issue (1): 80-84.

基于国家专利的中药复方治疗湿疹及特应性皮炎用药规律研究

出版日期:2024-02-25 上线日期:2024-03-13

Study on medication rules in the treatment of eczema and atopic dermatitis based on national patent Chinese herbal compound prescriptions

Published:2024-02-25 Online:2024-03-13

摘要/Abstract

摘要： 目的运用数据挖掘分析国家专利中药复方治疗湿疹及特应性皮炎的用药规律，旨在为新药研发和基础研究指明方向。方法检索国家知识产权局专利库中治疗湿疹及特应性皮炎的中药复方专利，借助中医传承辅助平台V2.5,通过文献计量法、数据挖掘分析法、关联规则分析法等对其进行统计分析，通过SPSS Modeler 18.0构建关联规则网络图，并借助SPSS 26.0进行聚类分析等。结果本研究共纳入治疗湿疹及特应性皮炎的内服中药复方425项，涉及380味中药，药物性味均以苦、寒为主，苦参、黄柏、地肤子、白鲜皮等为核心药物，多属肝经、胃经、肺经、脾经。对可能的新方剂的进一步研究。结论初步归纳出“清热利湿，祛风止痒”是中医临床应用于湿疹及特应性皮炎的基本原则，同时数据挖掘为临床防治提供新的理论依据。

关键词: 湿疹, 特应性皮炎, 数据挖掘, 中医传承辅助平台

Abstract: ObjectiveTo analyze the medication rules of national patent Chinese herbal compound prescriptions for eczema and atopic dermatitis based on data mining in order to direct the development of new medicines and basic researches.MethodsWe searched for Chinese herbal compound patents for the treatment of eczema and atopic dermatitis in the State Intellectual Property Office's patent database, and we statistically analyzed those patents using the bibliometric approach, data mining analysis, association rule analysis, etc.. Using the TCM Heritage Assist Platform V2.5, we created association rule network diagrams using SPSS Modeler 18.0 and made cluster analysis using SPSS 26.0.ResultsThis study examined 380 herbal medicines used in a total of 425 internal Chinese herbal compound formulas for the treatment of eczema and atopic dermatitis. All of the medicines were bitter and cold in nature, with Kushen, Difuzi, Huangbai and Baixianpi serving as the main ingredients; the majority of them functioned through the liver, stomach, lung, and spleen meridians. Further investigation into potential new prescriptions was made.ConclusionThe fundamental principle of "clearing heat and dampness, dispelling wind and relieving itch" is summarized as the main principle of clinical application of TCM for eczema and atopic dermatitis, and data mining provides new theoretical foundation for clinical prevention and therapy.

Key words:

Eczema, Atopic dermatitis, Data mining, TCM heritage assist platform

邵灵洋, 王海, . 基于国家专利的中药复方治疗湿疹及特应性皮炎用药规律研究[J]. 中国中西医结合儿科学, 2024, 16(1): 80-84.

SHAO Lingyang, WANG Hai. Study on medication rules in the treatment of eczema and atopic dermatitis based on national patent Chinese herbal compound prescriptions[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2024, 16(1): 80-84.