ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2024, Vol. 16 ›› Issue (2): 160-165.

• 小儿中药应用研究 • 上一篇    下一篇

定喘汤辅助治疗婴幼儿毛细支气管炎疗效和安全性的系统评价及Meta分析

  

  • 出版日期:2024-04-25 上线日期:2024-04-25

Systematic review and Meta-analysis of the efficacy and safety of Dingchuan decoction in the adjuvant treatment of infants with bronchiolitis

  • Published:2024-04-25 Online:2024-04-25

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摘要： 目的 系统评价定喘汤辅助治疗婴幼儿毛细支气管炎的疗效和安全性。方法 从建库至2022年7月29日，系统检索PubMed、Embase、Cochrane Library、中国知网(CNKI)、万方数据知识服务平台(Wanfang)、维普中文期刊服务平台(VIP)、中国生物医学文献服务系统(SinoMed)数据库，检索所有定喘汤辅助治疗婴幼儿毛细支气管炎的随机对照试验。按照纳入和排除标准筛选和纳入文献。使用Cochrane偏倚风险评价手册评估纳入文献质量，并对纳入文献进行数据提取。应用RevMan 5.4软件进行Meta分析。结果 共纳入13项研究，共1 222例患儿。结果显示：与西医常规疗法比，联合定喘汤能提高毛细支气管炎患儿总有效率[RR=1.21,95%CI(1.16,1.27),P<0.000 01],缩短咳嗽消失时间[MD=-1.48,95%CI(-1.77,-1.20),P<0.000 01]、喘憋消失时间[MD=-1.43,95%CI(-1.59,-1.27),P<0.000 01]、肺部啰音消失时间[MD=-1.87,95%CI(-2.01,-1.73),P<0.000 01]、住院时间[MD=-3.14,95%CI(-4.27,-2.01),P<0.000 01]。以上指标两组间差异均有统计学意义(P<0.05)。在安全性方面，未发现不良反应。结论 现有证据表明，定喘汤辅助治疗婴幼儿毛细支气管炎较西医常规疗法可提高总有效率，改善临床症状体征，临床疗效显著，且安全性良好。 

关键词: 毛细支气管炎, 定喘汤, 系统评价, Meta分析

Abstract: ObjectiveTo systematically evaluate the efficacy and safety of Dingchuan decoction in the adjuvant treatment of infants with bronchiolitis.MethodsSystematically search PubMed,Embase,Cochrane Library,CNKI,Wanfang Data Knowledge Service Platform(Wanfang),VIP Chinese Journal Service Platform (VIP),and SinoMed databases the time being from the construction of the databases to July 29,2022.Randomized controlled trials(RCTs) on Dingchuan decoction as an adjuvant therapy for infants with bronchiolitis were retrieved.Literatures were screened and included according to inclusion and exclusion criteria.The Cochrane Bias Risk Assessment Manual was used to assess the quality of the included literatures,and data were extracted from the included literatures.Meta-analysis was performed using RevMan 5.4 software.ResultsA total of 13 studies were included,with a total of 1 222 children.The results showed that,compared with conventional western medicine therapy,the combined Dingchuan decoction could improve the total effective rate in children with bronchiolitis［RR=1.21,95%CI(1.16,1.27),P<0.000 01］,shorten the disappearance time of cough ［MD=-1.48,95%CI(-1.77,-1.20),P<0.000 01］,shorten the disappearance time of wheezing ［MD=-1.43,95%CI(-1.59,-1.27),P<0.000 01］,shorten the disappearance time of lung rale［MD=-1.87,95%CI(-2.01,-1.73),P<0.000 01］,and shorten the length of hospitalization［MD=-3.14,95%CI(-4.27,-2.01),P<0.000 01］.All the differences in the above-mentioned indexes between the two groups were statistically significant(P<0.05).In terms of safety,no adverse reactions were found.ConclusionThe existing evidence shows that Dingchuan decoction can increase the total effective rate and improve clinical symptoms and signs compared with conventional western medicine therapy in the treatment of infantile bronchiolitis.The clinical efficacy is significant and the safety is good.

Key words:

Bronchiolitis, Dingchuan decoction, Systematic review, Meta analysis