ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2024, Vol. 16 ›› Issue (3): 191-197.doi: 10.3969/j.issn.1674-3865.2024.03.002

• 小儿哮喘疾病防治专栏 • 上一篇    下一篇

加减射干麻黄汤治疗儿童咳嗽变异性哮喘的疗效及安全性Meta分析

明溪, 王紫薇, 边际, 王博, 卢盈竹, 黄会惠   

  1. 650021 昆明，云南中医药大学第一附属医院儿科（明溪）；650051 昆明，云南中医药大学第一临床医学院中医儿科学专业研究生（王紫薇，边际，王博，卢盈竹，黄会惠）

  • 收稿日期:2024-04-22 出版日期:2024-06-25 上线日期:2024-08-26
  • 通讯作者: 明溪，E-mail：863455756@qq com
  • 基金资助:
    云南省万人计划青年拔尖人才专项(YNWR-QNBJ-2019-196)；云南省高层次中医药人才项目（学科带头人-中医儿科学）；国家自然科学基金（82060884）；熊磊全国名老中医药专家传承工作室项目；国家中医药管理局高水平中医药重点学科建设项目（ZYYZDXK-2023190）

Meta-analysis of the efficacy and safety of modified Shegan Mahuang decoction in the treatment of cough variant asthma in children

MING Xi, WANG Ziwei, BIAN Ji, WANG Bo, LU Yingzhu, HUANG Huihui.   

  1. The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine，Kunming 650021，China

  • Received:2024-04-22 Published:2024-06-25 Online:2024-08-26
  • Contact: MING Xi，E-mail：863455756@qq com

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摘要： 目的 运用Meta分析方法研究加减射干麻黄汤治疗儿童咳嗽变异性哮喘的疗效及安全性。方法 全面检索已发表中药射干麻黄汤为基础方或联合西药治疗儿童咳嗽变异性哮喘中干预措施为使用该方的临床随机对照试验的相关文献。两名评价人员分别进行文献检索，用改良的Jadad量表进行文献质量评价、筛选出符合纳入条件的文献后对数据进行提取，最后采用Rev Man 5.3软件进行Meta分析。结果 筛选并纳入13个随机对照试验，共1 491例患者，经Meta分析显示，观察组有效率优于对照组，差异有统计学意义[RR=1.23,95%CI=(1.18,1.29),z=9.23,P<0.000 01];咳嗽症状缓解时间短于对照组，差异有统计学意义[MD=-0.85,95%CI=(-0.94,-0.77),z=19.59,P<0.000 01];不良反应发生率低于对照组，差异有统计学意义[RR=0.40,95%CI=(0.27,0.60),z=4.42,P<0.000 01]。结论 加减射干麻黄汤治疗儿童咳嗽变异性哮喘具有良好的疗效及安全性。

关键词: 咳嗽变异性哮喘, 射干麻黄汤, 疗效, 安全性, Meta分析, 儿童

Abstract: Objective To investigate the efficacy and safety of modified Shegan Mahuang decoction in the treatment of cough variant asthma in children using Meta-analysis.Methods A comprehensive search of published literature was performed,concerning the clinical randomized controlled trials using Shegan Mahuang decoction as the basic formula or as the intervention measure in western medicine combined treatment for children with cough variant asthma .Two evaluators carried out the literature search,evaluated the quality of the literature using the modified Jadad scale,extracted the data after screening the literature that met the inclusion criteria,and then performed Meta-analysis using Rev Man 5.3 software. Results  A total of 13 randomized controlled trials involving 1 491 patients were included,and the results of Meta-analysis showed that:the effective rate of the observation group was better than that of the control group［RR=1.23,95%CI=(1.18,1.29),z=9.23,P<0.000 01］,and the time to relief of cough symptoms［MD=-0.85,95%CI=(-0.94,-0.77),z=19.59,P<0.000 01］ was shorter than that of the control group,and the incidence of adverse reactions［RR=0.40,95%CI=(0.27,0.60),z=4.42,P<0.000 01］ was lower than that of the controlgroup.Conclusion The treatment for cough variant asthma in children with modified Shegan Mahuang decoction has good efficacy and safety.


Key words:

Cough variant asthma, Shegan Mahuang decoction, Efficacy, Safety, Meta-analysis, Child