ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2024, Vol. 16 ›› Issue (3): 234-238.doi: 10.3969/j.issn.1674-3865.2024.03.011

• 临床研究 • 上一篇    下一篇

儿童肺炎支原体大叶性肺炎凝血功能临床研究

马云虹, 王双翼, 罗斐, 张元, 崔正九, 刁娟娟   

  1. 250014 济南，山东中医药大学中医儿科学专业研究生（马云虹，王双翼，罗斐，张元，崔正九）；250011 济南，山东中医药大学附属医院儿科（刁娟娟）

  • 收稿日期:2023-10-19 出版日期:2024-06-25 上线日期:2024-08-26
  • 通讯作者: 刁娟娟，E-mail:m1887020@163.com
  • 基金资助:
    国家中医药管理局中医药循证能力建设项目之专科专病循证能力提升项目（2019XZZX-EK004）

Clinical study on coagulation function of children with Mycoplasma pneumoniae lobar pneumonia

MA Yunhong, WANG Shuangyi, LUO Fei, ZHANG Yuan, CUI Zhengjiu, DIAO Juanjuan   

  1. School of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250014,China
  • Received:2023-10-19 Published:2024-06-25 Online:2024-08-26
  • Contact: DIAO Juanjuan，E-mail:m1887020@163.com

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摘要： 目的 研究儿童肺炎支原体大叶性肺炎凝血指标与疾病的相关性。方法 收集肺炎支原体大叶性肺炎儿童99例，记录血小板计数、国际标准化比值、血浆凝血酶原时间(PT)、PT活动度、活化部分凝血活酶时间、血浆纤维蛋白原、凝血酶时间、血浆D-二聚体、辨证分型、退热时间、咳嗽缓解时间、啰音消失时间、总病程、住院时间和住院费用，运用多重线性回归统计分析相关性。结果 凝血指标与住院时间、发热时间、住院费用之间存在多重线性回归关系，差异具有统计学意义(P<0.05)。D二聚体和病程时间以及血浆凝血酶原时间测定和咳嗽缓解时间之间存在一元线性回归关系，差异具有统计学意义(P<0.05)。结论 肺炎支原体感染大叶性肺炎儿童存在高凝状态，凝血功能与疾病的病情轻重、预后具有线性回归关系。

关键词: 大叶性肺炎, 肺炎支原体, 凝血, 相关性, 儿童

Abstract: Objective To study the correlation between coagulation indexes and the disease of Mycoplasma pneumoniae lobar pneumonia in children.Methods Totally 99 children with Mycoplasma pneumoniae lobar pneumonia were collected.The following data were recorded:platelet count (PLT),international normalized ratio（INR),plasma prothrombin time(PT),PT activity,activated partial thromboplastin time(APTT),plasma fibrinogen(Fib),thrombin time,plasma D-dimer,syndrome differentiation,fever remission time,cough relief time,rale disappearance time,total duration of disease,length of hospital stay and hospitalization cost.The correlation was analyzed by multiple linear regression statistics.Results There was multiple linear regression relationship between coagulation indexes and length of hospital stay,fever time and hospitalization cost(P<0.05),and the differences were statistically significant.There was a single linear regression relationship between D dimer and disease duration,plasma prothrombin time and cough relief time(P<0.05). Conclusion There is hypercoagulation in the children with lobar pneumonia infected by Mycoplasma pneumoniae.There is a linear regression relationship between the coagulation function and the severity and prognosis of the disease.


Key words:

Lobar pneumonia, Mycoplasma pneumoniae, Coagulation, Relationship, Child