关键词: 过敏性鼻炎, 中医药, 文献挖掘, 聚类分析, 儿童

Abstract: Objective  To collect clinical research on the treatment for allergic rhinitis in children with traditional Chinese medicine,disassemble its prescription and medication,find the frequency of each drug,the connection and laws among drugs,and analyze the high-frequency drugs to obtain the core drugs to guide the future clinical medication.Methods  (1) Search the full text database of Chinese academic journals,Chinese scientific and technology journals and Wanfang academic journals,online database of Chinese biomedical literature and Pubmed database for literature on clinical trials of "treating allergic rhinitis in children with Chinese medicine" from the establishment of the database to May 31,2022.(2) Use Note Express software for screening and rechecking,and the prescribed drugs in the literature were sorted out;(3) Use Excel to manage the data,calculate the interTCM associations using the SPSS Modeler Apriori algorithm to build the drug network;Data clustering analysis of high-frequency drugs was made by using SPSS 26.0,and the core drug dendrogram was obtained.Results  Totally 284 articles were included,and 303 prescriptions and 195 drugs were obtained.The frequency of drug occurrence,functioning meridians of property and taste,and the association among commonly used drugs were analyzed,and 3 groups of best drug association rules and 4 clustering prescriptions were obtained.Conclusion Through the analysis of the characteristics of drugs for allergic rhinitis in children,the clinical treatment is mainly to dispel wind and promote lung enlightenment,and tonifying lung,qi and spleen,and then differentiated treatment is performed according to the relevant clinical symptoms.

Key words:

Allergic rhinitis, Traditional Chinese medicine, Literature mining, Cluster analysis, Child