关键词: 抽动障碍, 网络药理学, 中药, 研究进展, 儿童

Abstract: With the development of society and the influence of the environment,the incidence of tic disorders (TD) has increased year by year in recent years,and it has become one of the more common pediatric diseases in clinical practice.The treatment for TD in western medicine is mainly based on dopamine (DA) and central α2 receptor agonists,combined with psychotherapy,which has certain efficacy,but its adverse reactions make some children intolerant.The holistic concept and treatment based on syndrome differentiation in traditional Chinese medicine have significant advantages in safety and efficacy in the prevention and treatment of TD.Single herbs,drug pairs and compounds in traditional Chinese medicine have multi-target and multi-pathway regulatory effects,which are consistent with the core idea of network pharmacology in modern theory.Therefore,network pharmacology methods are gradually being accepted and adopted by traditional Chinese medicine to study its mechanism of action.This paper reviews the research and application progress of network pharmacology in the mechanism of action of traditional Chinese medicine in the treatment of TD,and expounds the existing problems in the research,in order to provide reference for the application of network pharmacology in the research of traditional Chinese medicine in the treatment of TD.

Key words:

Tic disorders, Network pharmacology, Traditional Chinese medicine, Research progress, Child