ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2024, Vol. 16 ›› Issue (4): 349-354.doi: 10.3969/j.issn.1674-3865.2024.04.017

• 小儿中药应用研究 • 上一篇    下一篇

基于数据挖掘探讨张葆青教授治疗小儿抽动障碍用药规律研究

张昊晨, 张葆青, 王欣欣, 潘月丽   

  1. 250014 济南，山东中医药大学中医学院2021级中医儿科学专业研究生（张昊晨）；250000 济南，山东中医药大学附属医院儿科（张葆青，潘月丽）；276800，山东 日照，日照市中医院儿科（王欣欣）

  • 收稿日期:2024-01-07 出版日期:2024-08-25 上线日期:2024-08-26
  • 通讯作者: 潘月丽，E-mail:pyl_sd@163.com
  • 基金资助:
    国家中医药管理局中药循证能力提升项目（2019XZZX-EK001）

Discussion of Professor Zhang Baoqing′s medication rules in treating tic disorders in children based on data mining

ZHANG Haochen, ZHANG Baoqing, WANG Xinxin, PAN Yueli   

  1. 1Shandong Traditional Chinese Medicine University,Jinan 250014,China;2Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000,China;3Rizhao Hospital of Traditional Chinese Medicine,Rizhao 276800,China

  • Received:2024-01-07 Published:2024-08-25 Online:2024-08-26
  • Contact: PAN Yueli，E-mail:pyl_sd@163.com

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摘要： 目的 研究张葆青教授治疗小儿抽动障碍用药规律。方法 收集2022年5月至2023年4月张葆青教授诊治抽动障碍中药处方，运用IBM SPSS Statistics 23.0、IBM SPSS Modeler 18.0软件，对张葆青教授治疗抽动障碍处方的中药种类、频次、性味归经，以及选用方剂的药物群组、核心处方等进行分析总结。结果 共收集抽动障碍处方265首，涉及中药110味。功效以解表药、补虚药、清热药为主；药性以温、平为主，其次为微寒、寒；药味主要以苦、辛、甘居多；归经主要以肺经、肝经、脾经和胃经居多。关联规则分析得到了羌活-防风，焦栀子、甘草，蝉蜕-甘草，柴胡-炒白芍等常用药对；聚类分析显示了6个潜在药物群。结论 张葆青教授在治疗抽动障碍过程中“内风”“外风”并重，常从肺肝脾论治。

关键词: 抽动障碍, 数据挖掘, 用药规律, 儿童

Abstract: Objective To explore Professor Zhang Baoqing′s medication rules in treating tic disorders(TD) in children based on data mining.Methods From May 2022 to April 2023,the TCM prescriptions by Professor Zhang Baoqing in treating TD were collected.IBM SPSS Statistics 23.0 and IBM SPSS Modeler 18.0 were used to analyze the types,frequency,property and taste and the functioning meridians of the drugs used by Professor Zhang Baoqing.The drug groups in the prescription and core prescriptions were summarized.Results A total of 265 prescriptions for TD were collected,involving 110 TCM drugs.The efficacy was mainly for relieving,tonifying and clearing.The drug properties were mainly warm and mild followed by slightly cold and cold,and the taste was mainly bitter,pungent and sweet.The main channels were lung,liver,spleen and stomach.The common drug pairs were obtained by association rule analysis,such as Radix notopterygiae-Radix saposhnioviae,Radix gardenia-licorice,cicada-licorice,bupleurus-fried white peony,etc.The cluster analysis showed 6 potential drug groups.Conclusion Professor Zhang Baoqing pays equal attention to "internal wind" and "external wind" in the treatment of TD,and often treats TD from lung,liver and spleen.


Key words:

Tic disorder, Data mining, Medication rule, Child