ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2024, Vol. 16 ›› Issue (4): 359-362.

• 小儿中药应用研究 • 上一篇    下一篇

小儿清热化积散治疗儿童热性惊厥的临床疗效观察

  

  • 出版日期:2024-08-25 发布日期:2024-08-26

Clinical effect of Xiaoer Qingre Huaji powder on febrile convulsion in children

  • Online:2024-08-25 Published:2024-08-26

摘要: 目的 观察小儿清热化积散防治小儿热性惊厥的临床疗效。方法 选取2021年1月至2022年12月浙江省中医院儿科门诊及住院就诊的热性惊厥患儿102例,随机分为对照组50例和观察组52例。对照组予常规治疗,观察组在对照组治疗基础上加用小儿清热化积散口服治疗,两组连续观察3 d,收集相关指标;以3个月为1个随访周期,随访期间,对照组予地西泮预防惊厥,观察组予小儿清热化积散预防惊厥,随访1年;统计两组治疗期间的退热时间,惊厥再发次数,治疗前后中医证候积分改变情况;统计两组随访期间惊厥发生次数。结果 两组体温随治疗时间递减,观察组治疗后6 h、24 h、48 h和72 h体温低于对照组,差异有统计学意义(P<0.05)。观察组在整个治疗过程中,发热情况得到有效控制,达峰(体温≥39.0℃)(0.53±0.62)次,明显低于对照组(1.65±2.72)次,在接受治疗的72 h内,差异有统计学意义(P<0.05)。同时中医证候积分明显低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。两组随访1年,观察组未出现惊厥,对照组出现惊厥(0.55±0.55)次,观察组明显优于对照组,差异有统计学意义(P<0.01)。结论 小儿清热化积散防治小儿热性惊厥疗效确切,既可以显著缩短小儿发热时间,明显减少惊厥再发次数,又可以有效预防热性惊厥再发作,值得临床广泛推广应用。 

关键词: 热性惊厥, 小儿清热化积散, 治疗, 儿童

Abstract: ObjectiveTo observe the clinical effect of Xiaoer Qingre Huaji powder in the prevention and treatment of febrile convulsion in children.MethodsA total of 102 children with febrile convulsion were selected from the pediatric outpatients and inpatients of Zhejiang Hospital of Traditional Chinese Medicine from January 2021 to December 2022,and they were randomly divided into control group (50 cases) and observation group (52 cases).The control group was given conventional treatment,and the observation group was given oral treatment of Xiaoer Qingre Huaji powder on the basis of the the treatment for control group.The two groups were observed continuously for 3 days,and relevant indicators were collected.Three months was set as a follow-up course.During the follow-up,the control group was given diazepam to prevent convulsion,and the observation group was given Xiaoer Qingre Huaji powder to prevent convulsion,and they were followed up for 1 year.The time of fever relief,the number of recurrent convulsions,and the change in TCM syndrome score before and after treatment were counted.The number of convulsions in the two groups during follow-up was counted.ResultsThe body temperature of the two groups were decreased with treatment time,with the observation group being lower than the control group at 6h,24h,48h and 72h of treatment,and the difference was statistically significant (P<0.05).During the whole process of treatment,the fever was effectively controlled in the observation group,and the the number of reaching peak (body temperature≥39 ) was 0.53±0.62,significantly lower than the control group (1.65±2.72);in the 72 hours of treatment,the difference was statistical (P<0.05).At the same time,the TCM syndrome score was significantly lower than that of control group,and the difference was statistically significant (P<0.05).There was no statistical difference in the incidence of adverse reactions (P>0.05) between the two groups.The two groups were followed up for 1 year,the observation group did not have convulsion,while the control group had (0.55±0.55) times of convulsion,the observation group being significantly better than the control group,and the difference was statistically significant (P<0.01).ConclusionXiaoer Qingre Huaji powder is effective in preventing and treating febrile convulsion in children.It can shorten the fever duration,significantly reduce the frequency of recurrent convulsion,and prevent febrile convulsion recurrence effectively,which is worth clinical promotion and application.

Key words:

Febrile convulsion, Xiaoer Qingre Huaji powder, Treatment, Child