ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2024, Vol. 16 ›› Issue (5): 444-448.

• 临床研究 • 上一篇    下一篇

豉翘清热颗粒联合头孢呋辛治疗小儿急性呼吸道感染的效果及对炎症因子的影响

  

  1. 安阳市人民医院儿科

  • 出版日期:2024-10-25 发布日期:2024-11-03

Effect of Chiqiao Qingre granules combined with cefuroxime in the treatment of acute respiratory tract infection in children and its influence on inflammatory factors

  1. Department of Pediatrics,Anyang People′s Hospital
  • Online:2024-10-25 Published:2024-11-03

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摘要：

目的 探索豉翘清热颗粒联合头孢呋辛治疗小儿急性呼吸道感染(ARTI)的效果及对炎症因子的影响。方法 选取2021年3月至2023年3月安阳市人民医院收治住院的ARTI患儿103例，根据治疗方法不同将其分为观察组(豉翘清热颗粒联合头孢呋辛治疗)52例，对照组(头孢呋辛治疗)51例。治疗1周后观察两组临床疗效、症状消失时间，比较两组患儿炎症因子、免疫功能及不良反应发生率。结果 治疗后观察组总有效率为90.4%(47/52),显著高于对照组70.6%(36/51),差异有统计学意义(P<0.05)。观察组发热、咳嗽、咽干、流涕、胸痛等多项症状消退时间均显著短于对照组，差异有统计学意义(P<0.05)。两组患儿血清炎症因子白细胞介素-6、血清淀粉样蛋白A、C反应蛋白及降钙素原含量均减少，且观察组小于对照组(P<0.05)。两组患儿免疫功能Th1与Th1/Th2均增加，且观察组大于对照组(P<0.05);Th2均减少，且观察组小于对照组(P<0.05)。两组患儿不良反应发生率比较差异无统计学意义(P>0.05)。结论 豉翘清热颗粒联合头孢呋辛治疗小儿ARTI的效果更好，可加快症状消退，缓解机体炎症反应，维持免疫平衡，且安全可靠。  

关键词: 急性呼吸道感染, 头孢呋辛, 豉翘清热颗粒, 免疫平衡, 儿童

Abstract: ObjectiveTo explore the effect of Chiqiao Qingre granules combined with cefuroxime in the treatment of acute respiratory tract infection(ARTI) in children and its influence on inflammatory factors.MethodsA total of 103 children with ARTI admitted to our hospital from March 2021 to March 2023 were selected and divided into observation group(treated with Chiqiao Qingre granules combined with cefuroxime,n=52) and control group(treated with cefuroxime,n=51) according to different treatment methods.The clinical curative effect and symptom disappearance time of the two groups were observed,and the inflammatory factors,immune function and the incidence of adverse reactions of the two groups were compared.ResultsAfter treatment,the total effective rate of the observation group was 90.4%(47/52),significantly higher than that of the control group(70.6%,36/51)(P<0.05).Compared with the control group,the disappearance time of fever and other symptoms,such as cough,dry throat,running nose and chest pain,in the observation group was significantly shorter(P<0.05).The levels of serum interleukin-6(IL-6),serum amyloid A(SAA),C-reactive protein(CRP) and procalcitonin(PCT) in the two groups were reduced,and the level in the observation group was lower than that in the control group(P<0.05).The Th1 and Th1/Th2 in the two groups were increased,and the Th1/Th2 in the observation group was higher than that in the control group(P<0.05).The Th2 in both groups was decreased,and the Th2 in the observation group was lower than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).ConclusionChiqiao Qingre granules combined with cefuroxime is more effective in treating ARTI in children,which can speed up the disappearance of symptoms,relieve the body′s inflammatory response,and maintain immune balance,and it is safe and reliable.

Key words: Acute respiratory tract infection；Cefuroxime, Chiqiao Qingre granules, Immune balance, Child