ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2025, Vol. 17 ›› Issue (1): 8-12.doi: 10.20274/j.cnki.issn.1674-3865.2025.01.002

• 儿童内分泌疾病专栏 • 上一篇    下一篇

知母-黄柏药对在性早熟中的临床应用研究

陈娜,李连科,卢以红,杨洋,陶琼,陈竹   

  1. 550003 贵阳,贵州中医药大学第二附属医院儿科(陈娜,杨洋,陶琼,陈竹);550025 贵阳,贵州中医药大学第二临床医学院2022级中西医结合专业研究生(李连科,卢以红)
  • 收稿日期:2024-09-01 修回日期:2024-12-28 出版日期:2025-02-25 上线日期:2025-02-25
  • 通讯作者: 陈竹,E-mail:918236355@qq.com
  • 基金资助:
    贵州省卫生健康委科学技术基金项目(gzwkj2022-400);贵州中医药大学大学生创新创业训练计划项目(贵中医大创合字〔2023〕17号)

Research on the clinical application of Zhimu-Huangbai in precocious puberty

CHEN Na1,LI Lianke2,LU Yihong2,YANG Yang1,TAO Qiong1,CHEN Zhu1   

  1. 1Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550003,China;2Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China
  • Received:2024-09-01 Revised:2024-12-28 Published:2025-02-25 Online:2025-02-25
  • Contact: CHEN Zhu,E-mail:918236355@qq.com
  • Supported by:
    Science and Technology Fund Project of Guizhou Provincial Health Commission(No.gzwkj2022-400)

摘要: 知母-黄柏在临床过程中是常用的药对,二药配伍具有滋阴清热、泻火解毒功效。现代研究发现,知母-黄柏药对富含槲皮素、山柰酚、巴马汀、豆甾醇、芒果苷、小檗碱等主要活性成分,具有抗炎、抗氧化、降血糖、调血脂等作用。临床应用广泛,主要用于治疗儿童性早熟、糖尿病、糖尿病肾病等疾病。笔者通过从化学成分、药理作用、临床应用角度出发,阐述近年来知母-黄柏在性早熟方面的应用研究,以期为该药对在性早熟方面的科学应用及新药研发提供理论依据。

关键词: 性早熟, 知母-黄柏, 活性成分, 临床应用研究, 儿童

Abstract: Zhimu-Huangbai is a commonly used medicine pair in clinical practice,and the compatibility of the two drugs has the effects of nourishing yin and clearing heat,purging fire and detoxifying.Modern studies have found that Zhimu-Huangbai has anti-inflammatory,antioxidant,hypoglycemic,and lipidemic regulation effects because of its main active ingredients such as quercetin,kaempferol,barmatine,stigmasterol,mangiferin,berberine,etc.It is widely used in clinical practice,mainly for the treatment of precocious puberty,diabetes,diabetic nephropathy and other diseases in children.From the perspectives of chemical composition,pharmacological effects and clinical application,this paper expounds the application research of Zhimu-Huangbai in precocious puberty in recent years,in order to provide a theoretical basis for the scientific application of the drug in precocious puberty and for the research and development of new drugs.

Key words: Precocious puberty, Zhimu-Huangbai, Active ingredients, Clinical application research, Child