ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2025, Vol. 17 ›› Issue (1): 45-49.doi: 10.20274/j.cnki.issn.1674-3865.2025.01.009

• 临床研究 • 上一篇    下一篇

不同年龄段儿童高尿酸血症危险因素分析

方艳莹，甘嘉慧，徐钰茵，徐梓莹，司徒美玲，余淑娟   

  1. 529300 广东 开平，开平市中心医院儿内科（方艳莹，甘嘉慧，徐钰茵，余淑娟）,保健科（司徒美玲）；开平市妇幼保健院儿科（徐梓莹）
  • 收稿日期:2024-06-05 修回日期:2024-08-15 出版日期:2025-02-25 上线日期:2025-02-25
  • 通讯作者: 方艳莹，E-mail:522133923@qq.com
  • 基金资助:
    江门市医疗卫生领域科技计划项目(2022YL10009)

Analysis of risk factors for hyperuricemia in children of different ages

FANG Yanying1,GAN Jiahui1,XU Yuyin1,XU Ziying2,SITU Meiling1,YU Shujuan1   

  1. 1Kaiping City Centre Hospital,Kaiping 529300,China;2Kaiping Maternal and Child Health Hospital,Kaiping 529300,China
  • Received:2024-06-05 Revised:2024-08-15 Published:2025-02-25 Online:2025-02-25
  • Contact: FANG Yanying，E-mail:boyk@vip.qq.com
  • Supported by:
    Science and Technology Planning Project for Medical Care in Jiangmen City(No.2022YL10009)

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摘要： 目的 检测不同年龄段儿童（0～14岁）血尿酸水平，调查其地区的高尿酸发生率以及分析其与性别、年龄、体型-体质量指数以及生活习惯［包括进食海鲜，进食老火汤/炖汤，进食蔬菜，进食饮料，进食甜食，每日饮水量（mL），每天的运动量(min)等］的关系。方法 对2022年1月至2023年9月开平市中心医院及开平市妇幼保健院就诊的1 209例儿童作为研究对象，测量身高/身长、体质量、血尿酸进行检测，按不同年龄及性别进行分组，调查不同年龄组及不同性别儿童血尿酸水平，并根据血尿酸水平进行分组，分析该地区的尿酸现况以及高尿酸血症的发生率，同时探讨高尿酸血症儿童其与性别、年龄、体型-体质量指数以及生活习惯的关系。结果 血尿酸在不同性别中的分布差异无统计学意义（P>0.05），在不同年龄、体型的儿童中，血尿酸水平出现随年龄、体型增长而逐渐增高的趋势。高尿酸血症总检出率为20.18%（244/1 209），不同性别高尿酸血症检出率比较差异无统计学意义（P>0.05）；不同年龄、体型高尿酸血症检出率比较，差异有统计学意义（P<0.01）。Logistic回归分析结果显示，进食海鲜、进食饮料及喜好甜食是引起高尿酸血症的危险因素，增加蔬菜的进食、饮水量以及适当的运动量是尿酸的保护因素。结论 开平市地区儿童的血尿酸水平随着年龄增长及体型改变有所增高，与性别无特定关系，高嘌呤及高糖食物是引起高尿酸血症的危险因素。

关键词: 高尿酸, 发生率, 影响因素, 儿童

Abstract: Objective To measure serum uric acid(SUA) levels in children of different ages(0 to 14 years),investigate the incidence of high level of uric acid in those regions,and analyze its association with gender,age,body size-body mass index(BMI),and living habits［including consumption of seafood,consumption of long-boiled soup/stew,consumption of vegetables,consumption of beverages,consumption of sweets,daily water intake(mL) and daily exercise (min)］.Methods Totally 1 209 children visiting Kaiping City Centre Hospital and Kaiping Maternal and Child Health Hospital from January 2022 to September 2023 were enrolled in the study.Height/length,weight and SUA of the children were measured,and the children were grouped according to age and gender in order to investigate the SUA levels of children in different age groups and genders.In addition,the children were grouped according to the SUA level to investigate the current situation of uric acid and the incidence of hyperuricaemia in the region.In the meantime,the relationship between hyperuricaemia(HUA) in the children and their gender,age,body size-BMI and living habits were also investigated.Results The distribution of SUA levels showed no statistically significant difference between different genders(P>0.05). In children of different ages and body types, SUA levels exhibited a trend of gradual increase with age and body type growth. The overall detection rate of hyperuricemia was 20.18%(244/1 209), and the comparison of the detection rates of hyperuricemia between different genders showed no statistically significant difference(P>0.05). However, the comparison of hyperuricemia detection rates among different ages and body types showed statistically significant differences(P<0.01). Logistic regression analysis revealed that seafood consumption, beverage intake, and a preference for sweet foods were risk factors for hyperuricemia, while increased vegetable intake, fluid consumption, and appropriate exercise were protective factors for uric acid levels. Conclusion The level of SUA in children in Kaiping City increases with age and changes in body type, with no specific relation to gender; high-purine and high-sugar foods are risk factors for hyperuricemia.

Key words: High level of uric acid, Incidence rate, Influencing factors, Child