Abstract:
Objective
To explore the predictive value of TNF-α and IL-2 levels in early myocardial injury in children with sepsis.
Methods
A total of 64 cases of children with sepsis admitted to General Ⅱ Emergency Department of our hospital from January 2016 to June 2016 were randomly selected as the treatment group. Another 64 cases of routinely infected children were chosen as the observation group; meanwhile, 64 cases of normal children were included as the control group. The levels of IL-2 and TNF-α in the three groups were detected by means of Elisa and chemiluminescence immunoassay, respectively, and the changes of the two levels at 12 hours, 24 hours and 48 hours after treatment were observed and compared. The cardiac function indexes (including LAD, LVEF, LVEDP) in the three groups were detected through echocardiography. The relationship between serum levels of TNF-α and IL-2 and the changes of cardiac function in children with sepsis was analyzed.
Results
There were significant differences in serum levels of TNF-α and IL-2 among the three groups (P<0.05). After a further comparison, the serum levels of TNF-α and IL-2 in treatment group were significantly higher than those of the observation group and control group, and the observation group was significantly higher than the control group, the differences being statistically significant (P<0.05). As the treatment time increased, the serum levels of TNF-α and IL-2 in treatment group were significantly lower at 48h than those at 12h and 24h after treatment, and the levels at 24h after treatment was significantly lower than that at 12h after treatment, the difference being statistically significant(P<0.05). Correlation analysis showed that serum TNF-α and IL-2 were positively correlated with LAD and LVEDP in children with sepsis, but negatively correlated with LVEF(P<0.05).
Conclusion
The serum levels of TNF-α and IL-2 in children with sepsis are obviously higher and they are closely related to the treatment time, as well as the degree of cardiac function injury, which is of great importance to judging the prognosis of the patients.

Key words: Sepsis, Early myocardial injury, TNF-α, IL-2, Child