Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2010, Vol. 2 ›› Issue (5): 411-416.doi: 10.3969/j.issn.1674-3865.2010.05.012
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HU Siyuan,MA Rong,XU Qiang
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Abstract: ObjectiveTo evaluate the effect and safety of Astragalus membranaceus Injection(AMI) combined with convetional western medicine in treating children′s viral myocarditis(VMC). MethodsWe formulated the inclusion criteria, exclusion criteria and retrieval strategy on the basis of original literatures, searched Cochrane central Register of Controlled Trials,PUBMED,CNKI,VIP.Randomized controlled trials (RCTs) of routin treatment (RT) with AMI compared with RT only in treating children′s VMC and eligible studies were included;the methodological quality of inclusive trials was assessed by Jadad scale of Cochrane Collaboration recommended. Metaanalysis was used to analyse the data by statistical software RevMan4.2.10. We adopted clinical effective rate, EKG, myocardial enzymes, cardiac function and adverse reaction rate as observation indexs, made qualitative and quantitative analysis. ResultsWe found 291 literatures totally. Among these literatures, 22 RCTs(934/847)were selected. All RCTs were low methodological quality according to Jadad score index. Metaanalysis indicated that RR and 95% CIof 21 RCTs′s(894/807)effective rate was 4.53[3.33, 6.17].WMD and 95% CIof 7 RCTs′s(342/322)improving CKMB and 1 RCT′s (44/39)improving EF were -10.19[-14.02, -6.36] and 2.30[-3.22, 7.82] respectively. RR and 95% CI of7 RCTs′s(302/264)EKG improvement rate was 4.62[2.72, 7.84]. This systematic review showed that AMI was effective and safe for children′s VMC. In view of effective rate, EKG improvement rate and improving CKMB, there were great difference between two groups (P<0.00001). ConclusionsAMI is effective and safe for children′s VMC;it can improve clinical effect rate and EKG improvement rate, decrease CKMB in blood for.However, the evidence is not strong because of low methodological quality of these literatures. To further evaluate the effect and safety of AMI for children′s VMC more rationally designed and strictly executed RCTs with large samples need to be made
Key words: VMC/combined therapy of Chinese with western medicine, AMI/treatment application, EKG, methodology, children
HU Siyuan,MA Rong,XU Qiang . Astragalus membranaceus Injection(AMI)in children′s viral myocarditis (VMC): a systematic review[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2010, 2(5): 411-416.
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