Abstract:

Objective：To investigate the risk factors related to acute kidney injury after cardiopulmonary bypass for non-cyanotic congenital heart disease in children.Methods：A total of 450 children with non-cyanotic congenital heart disease were included as the research subjects, who received cardiopulmonary bypass in the Hunan Children's Hospital from Aug.2013 to Aug.2016.These children were divided into two groups based on whether AKI occurred after operation: AKI groups(80 children) and non-AKI group(370 children).The general and clinical data of the children were collected, and single factor analysis and logistic regression analysis were performed to investigate the related risk factors.Results：there was no statistical difference in gender, body weight, urea nitrogen, left ventricular ejection fraction or hemoglobin between the two groups(P>0.05). There was statistical difference in age, serum creatinine, history of pneumonia or heart failure, cardiopulmonary bypass time and aortic clamping time or postoperative hypotension between the two groups(P<0.05). The Logistic regression analysis showed that the risk factors were as follows: age≤1 year old, history of pneumonia or heart failure, cardiopulmonary bypass time and aortic clamping time.Conclusion：During the cardiopulmonary bypass surgery for children with non-cyanotic congenital heart disease, it is effective in controlling the disease to choose the proper age for operation, shorten the cardiopulmonary bypass time as well as the aortic clamping time, and to prevent complications, which can reduce the morbidity of AKI in children.

Key words: Non-cyanotic congenital heart disease, Cardiopulmonary bypass, Acute kidney injury, Child