Abstract: Attention deficit hyperactivity disorder（ADHD） is a common psychosomatic disease in childhood. Modern Chinese medicine believes that imbalance between yin and yang is its basic pathogenesis. With the changes of the times, children's diet, emotions and other pathogenic factors have undergone great changes, and yin and yang are constantly changing. In the process, its pathogenesis has developed from a low baseline level of yin and yang imbalance to the current high baseline level of yin and yang imbalance, from yin deficiency resulting in substantial yin deficiency and yang hyperactivity to current yang hyperactivity leading to exhaust of yin liquid. The main clinical syndrome type has changed from yin-deficiency of liver and kidney to excessive heat of heart and liver and inside disturbance of phlegm and heat, and the treatment should focus on the root causes. The first step is to clear the heat of the heart and liver to achieve the balance of yin and yang. By systematic biological method, experimental researches at home and abroad have proved that the relationship between monoamine neurotransmitter dopamine and norepinephrine synthesis, release, and clearance, between dopamine D1-like receptors and D2-like receptors, pro-inflammatory factors and anti-inflammatory factors, which antagonize each other, influence each other, and adjust each other, is closely related to the theory of yin and yang balance in traditional Chinese medicine. At present, the relationship between promoting vesicle circulation factors and inhibiting vesicle circulation factors in dopamine synaptic vesicle circulation is being studied, in order to provide new targets and directions for traditional Chinese medicine treatment of attention-deficit hyperactivity disorder.

Key words:

ADHD, Yin-yang theory, Pathogenesis, Prognosis