Abstract: Objective To observe the antipyretic effect of external application of self-made TCM granules on babies aged 0-4 months infected with COVID-19.Methods Totally 132 babies aged 0-4 months with moderate fevel or above due to COVID-19 infection were chosen,who were treated in Suqian TCM Hospital from Nov. 2022 to Jan. 2023,and they were divided into two group:68 in observation group and 64 in control group.In control group,the babies with body temperature ≥38 ℃ were given medical antipyretic patches on their forehead;in observation group,the babies received external application of self-made TCM granules on Shenque acupoint;after 3 days of treatment,the antipyretic effect was recorded.For those with bacterial infection,febrile convulsions,etc.,the symptomatic treatment of anti-infection,fluid supplimentation and stopping convulsions was performed.Compare the antipyretic effect and the starting time of antipyretic effect after treatment between the two groups.Results The total effect rate of observation group was 92.65%(63/68),significantly higher than that of control group(76.56%,49/64),and the differences were statistically significant(P<0.05).The dorp in temperature of observation group at 6h,24h,48h and 72h after treatment was greater than that of control group(P<0.05).The starting time of antipyretic effect in observation group was prior to that in control group,and there was statistical difference between the two groups(P<0.05).Conclusion The external application of self-made TCM granules has significant antipyretic effect on the babies aged 0-4 month infected with COVID-19;it can greatly shorten the duration of moderate fever or above and fasten the starting of antipyretic effect,and there is no adverse reaction,so it is worthy of clinical application.

Key words:

COVID-19 infection, Fever, External application of self-made TCM granules, Babies aged 0-4 months