Abstract: Objective To explore the medication rules or insect medicine compound in the treatment of children with tic disorder (TD).Methods By comprehensively collecting and sorting out the insect compound prescriptions of traditional Chinese medicine in the treatment of children's TD in CNKI and Wanfang databases, and using the Traditional Chinese Medicine Inheritance Support Platform, the medication rules of insect medicine compound in the treatment of children's TD were mined and analyzed.Results In this study, 134 insect compound prescriptions were screened, involving 173 traditional Chinese medicines. Among them, there were 17 kinds of insect drugs, with a total of 357 times of application. Bombyx batryticatus, scorpion, cicada slough and keel were used more frequently in insect drugs. In the compound, the compatibility frequency of five kinds of drugs was the highest, involving the drugs calming liver and stopping wind, tonifying deficiency, relieving exterior symptoms, clearing heat, resolving phlegm and relieving cough and asthma, accounting for 69.86%(1 217/1 742) of the total application. The drug properties of the compound Chinese medicine were cold, neutral and warm, accounting for 90.47% (1 576/1 742). The drugs of sweet, pungent and bitter flavor accounted for 82.55%(2 072/2 510). The drugs functioning through liver, spleen and lung meridians accounted for 53.96%(2 214/4 103). Conclusion The application of insect medicine compound in the treatment of TD in children can give full play to the advantages of insect medicines, such as dredging collaterals and searching wind, eliminating phlegm and calming liver and stopping wind and movement, in order to calm liver and stop wind, remove phlegm and fire, tonify spleen and kidney, and promote blood circulation and remove blood stasis, while paying attention to regulating qi movement of the whole body. All of these are the characteristics of traditional Chinese medicine in the clinical treatment of TD in children.

Key words:

Tic disorder, Insect drugs, Medication rules, Chinese medicine