Abstract: Objective To observe the clinical effect of traditional Chinese medicine combined with repetitive transcranial magnetic stimulation in the treatment of Tourette syndrome.Methods A total of 58 patients treated in our hospital from January 2021 to July 2023 were randomly divided into western medicine group(n=20)，traditional Chinese medicine group(n=17) and combined treatment group(n=21).The patients in the three groups were treated with traditional Chinese medicine,traditional Chinese medicine combined with low frequency repetitive transcranial magnetic therapy,and aripiprazole,respectively.Results There was no statistically significant difference in the total clinical effective rate among the three groups (P>0.05).The group * time interaction effect of YGTSS score was statistically significant(P<0.05).YGTSS scores in all three groups decreased with treatment time.Compared with before treatment in each group,the treatment for all three groups was able to effectively improve YGTSS scores (P=0.000).After treatment,there was no significant difference in YGTSS scores among the three groups(P>0.05).The Conners Parental Questionnaire showed statistically significant group * time interaction effects(P<0.05) in the scores of four factors:conduct problems,physical and mental disorders,impulsivity-hyperactivity,and hyperactivity index.The scores of each factor in the Conners parental questionnaire in three groups decreased with treatment time.Compared with before treatment in each group,the treatment for all three groups was able to effectively improve the scores of each factor in the Conners parental questionnaire,and the difference was statistically significant(P<0.05).The combined treatment group showed better improvement than the western medicine group in four factors:conduct problems,physical and mental disorders,impulsivity-hyperactivity,and hyperactivity index,with statistical significance(P<0.05);the improvement in impulsivity-hyperactivity and hyperactivity index was better than that in the Chinese medicine group,with statistical significance (P<0.05).There was no statistically significant difference in the two factors of learning problems and anxiety among the three treatment groups (P>0.05).Conclusion Traditional Chinese medicine combined with low-frequency repetitive transcranial magnetic therapy for Tourette syndrome can not only relieve tic symptoms faster,but also improve children's psychological and emotional disorders such as physical and mental disorders and conduct problems,especially in the improvement of hyperactivity and impulsivity-related behavior problems,which is worthy of clinical application.

Key words:

Tourette syndrome, Traditional Chinese and western medicine, Treatment