Abstract: Objective To systematically evaluate the efficacy and safety of Dingchuan decoction in the adjuvant treatment of infants with bronchiolitis.Methods Systematically search PubMed,Embase,Cochrane Library,CNKI,Wanfang Data Knowledge Service Platform(Wanfang),VIP Chinese Journal Service Platform (VIP),and SinoMed databases the time being from the construction of the databases to July 29,2022.Randomized controlled trials(RCTs) on Dingchuan decoction as an adjuvant therapy for infants with bronchiolitis were retrieved.Literatures were screened and included according to inclusion and exclusion criteria.The Cochrane Bias Risk Assessment Manual was used to assess the quality of the included literatures,and data were extracted from the included literatures.Meta-analysis was performed using RevMan 5.4 software.Results A total of 13 studies were included,with a total of 1 222 children.The results showed that,compared with conventional western medicine therapy,the combined Dingchuan decoction could improve the total effective rate in children with bronchiolitis［RR=1.21,95%CI(1.16,1.27),P<0.000 01］,shorten the disappearance time of cough ［MD=-1.48,95%CI(-1.77,-1.20),P<0.000 01］,shorten the disappearance time of wheezing ［MD=-1.43,95%CI(-1.59,-1.27),P<0.000 01］,shorten the disappearance time of lung rale［MD=-1.87,95%CI(-2.01,-1.73),P<0.000 01］,and shorten the length of hospitalization［MD=-3.14,95%CI(-4.27,-2.01),P<0.000 01］.All the differences in the above-mentioned indexes between the two groups were statistically significant(P<0.05).In terms of safety,no adverse reactions were found.Conclusion The existing evidence shows that Dingchuan decoction can increase the total effective rate and improve clinical symptoms and signs compared with conventional western medicine therapy in the treatment of infantile bronchiolitis.The clinical efficacy is significant and the safety is good.

Key words:

Bronchiolitis, Dingchuan decoction, Systematic review, Meta analysis