Abstract: Objective To investigate the efficacy and safety of modified Shegan Mahuang decoction in the treatment of cough variant asthma in children using Meta-analysis.Methods A comprehensive search of published literature was performed,concerning the clinical randomized controlled trials using Shegan Mahuang decoction as the basic formula or as the intervention measure in western medicine combined treatment for children with cough variant asthma .Two evaluators carried out the literature search,evaluated the quality of the literature using the modified Jadad scale,extracted the data after screening the literature that met the inclusion criteria,and then performed Meta-analysis using Rev Man 5.3 software. Results  A total of 13 randomized controlled trials involving 1 491 patients were included,and the results of Meta-analysis showed that:the effective rate of the observation group was better than that of the control group［RR=1.23,95%CI=(1.18,1.29),z=9.23,P<0.000 01］,and the time to relief of cough symptoms［MD=-0.85,95%CI=(-0.94,-0.77),z=19.59,P<0.000 01］ was shorter than that of the control group,and the incidence of adverse reactions［RR=0.40,95%CI=(0.27,0.60),z=4.42,P<0.000 01］ was lower than that of the controlgroup.Conclusion The treatment for cough variant asthma in children with modified Shegan Mahuang decoction has good efficacy and safety.

Key words:

Cough variant asthma, Shegan Mahuang decoction, Efficacy, Safety, Meta-analysis, Child