Abstract: Functional constipation(FC) is a kind of functional intestinal disease with the main clinical manifestations of difficulty in defecation, reduced frequency of defecation or incomplete defecation, and it is one of the common and frequently-encountered diseases in pediatrics, which will seriously affect the children's quality of life and psychological health, and bring certain troubles to the children and their families. In recent years, with the gradual deepening of the research on the "brain-gut axis", more and more evidence have shown that there is a close connection between the brain and the intestine, and the "brain-gut axis" is a neuro-endogenous network system mechanism of bidirectional transportation mechanism between the brain and the gastrointestinal tract, which is composed of the central nervous system, the autonomic nervous system, and the enteric nervous system. The "brain-gut axis" as a neuro-endocrine network system consisting of the central nervous system, autonomic nervous system and enteric nervous system to liaise between the brain and the gastrointestinal tract, brain-gut peptides are able to connect and regulate the various aspects of the interaction of the "brain-gut axis", and the production development of FC is also closely related to the "brain-gut axis". In traditional Chinese medicine theory, the pathogenesis of constipation is a conduction disorder in the large intestine, and the brain and intestine are closely related. The brain resides in the upper part of the brain body, which governs the five viscera and six bowels, and the intestine resides in the lower part of the intestine, which transmits and transforms the dregs and affects the human body's qi, and when the intestine and bowels are functions smoothly, then the spirit of the government is bright mind is clear. The physiology of the brain and intestine is connected in physiology and related to each other in pathology, and the dysfunction of the brain and the intestine jointly leads to the occurrence of FC in children. Based on the theory of "brain-gut axis", and combined with Chinese medicine theory and etiology, this paper discusses the influence of "brain-gut axis" on children's FC, and analyzes the treatment for children's functional constipation based on the theory of "brain-gut axis". 

Key words:

Functional constipation, Brain-gut axis, Child