Table of Content

25 October 2017, Volume 9 Issue 5 Previous Issue    Next Issue

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Effect of Dingchuan decoction on the inflammatory cells in BALF of young rats infected with RSV CUI Zhenze，HUANG Yan，XU Chao 2017, 9 (5):  369-371.  doi: 10.3969/j.issn.1674-3865.2017.05.001 Abstract ( 676 )   PDF (406KB) ( 245 )   Save Objective To observe the changes of the total number and classification of BALF in young rats infected with RSV as well as the effect of Dingchuan decoction on it. Methods Twenty-seven Wistar rats were randomly divided into normal group, RSV model group and Dingchuan decoction group, 9 rats in each group. Except for the normal group, the rats in the other two groups were given RSV(Long bead) virus for nose dripping to get modeling, and after modeling the rats in normal group and model group were given gavage with equal volume of physiological saline. The Dingchuan decoction group was gavaged with Dingchuan decoction. HE staining method was used to observe the change of inflammation in lung tissues of rats; the cell smear-Ruish-Giemsa staining was used to determine the cell classification count in BALF of rats in each group. Results Pathology displayed: compared with the normal group, the inflammation of lung tissue in RSV model group was obvious and inflammatory cells increased, and after Dingchuan decoction intervention lung tissue inflammation was improved; compared with the normal group, the total cell count and the indexes of RSV model group were higher, and the difference was statistically significant(P<0.05). Compared with the model group, the total cell count and indexes of Dingchuan decoction group were significantly decreased, and the difference was statistically significant(P<0.05). Conclusion The mechanism of Dingchuan decoction in RSV infection in rats may be related to the inhibition of inflammatory cells in rat BALF. Related Articles | Metrics

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Clinical effect of Shenzong granule on improving micro-inflammation of children with primary nephrotic syndrome SUN Xiangbo，YU Nina，PAN Yueli 2017, 9 (5):  372-374.  doi: 10.3969/j.issn.1674-3865.2017.05.002 Abstract ( 595 )   PDF (513KB) ( 123 )   Save Objective To observe the clinical effect of Shenzong granule on children with primary nephrotic syndrome and its influence on micro-inflammation. Methods A total of 40 PNS children were include in the research, who were treated in the Affiliated Hospital of Shandong TCM University from March 2012 to March 2014, and they were randomly divided into two groups ,20 cases in the observation group and 20 in the control group. Both groups were treated with conventional symptomatic treatment, and prednisone at 2 mg/(kg·d) was given, which was used for 2 weeks after the urine protein turned negative, and then it was given every other day at the same dose for continuously 4 weeks; after that, a dose of 2.5 mg was reduced every 2 to 4 weeks until it was stopped. On this basis, the observation group was also given Shenzong granule, two months as a course. Observe the clinical effect and 24h content of urine protein, and the level of serum albumin, total cholesterol and hypersensitive C-reactive protein. Results The total effective rate of observation group was 85%(17/20), which was not statistically different from that of control group(75%,15/20)(P>0.05). Compared with before treatment, the serum albumin level in both groups was significantly higher, while the level of hypersensitive C-reactive protein, 24h urine protein and total cholesterol was significantly lower after treatment, the difference being statistical(P<0.05). After treatment, the serum albumin level was significantly higher than that of control group, while the level of hypersensitive C-reactive protein, 24h urine protein and total cholesterol was significantly lower, and there was statistical difference(P<0.05). Conclusion The treatment with hormone and Shenzong granule for children with PNS can significantly down-regulate the level of serum lipid and hypersensitive C-reactive protein, which is effective in improving the micro-inflammation in PNS children. Related Articles | Metrics

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Clinical effect of Pediatric Purpura Rash Elimination Particles on children with Henoch Schonlein purpura and its influence on the levels of IL-4 and IL-6 ZHU Haoyu, QIAN Meijia,FENG Xiaochun 2017, 9 (5):  375-378.  doi: 10.3969/j.issn.1674-3865.2017.05.003 Abstract ( 697 )   PDF (566KB) ( 195 )   Save Objective To observe the clinical effect of Pediatric Purpura Rash Elimination Particles on children with Henoch Schonlein purpura and its influence on the levels of IL-4 and IL-6. Methods A total of 60 children with Henoch Schonlein purpura were selected from Outpatient Department of Pediatrics and Inpatient Department of Changchun University of TCM Affiliated Hospital, who were treated from January 2016 to December. They were divided into observation group and control group with 30 cases in each group according to random number table method. The control group was given Xiyanping injection and vitamin C, 10% calcium gluconate injection for intravenous symptomatic treatment. On the basis of the treatment for the control group, Pediatric Purpura Rash Elimination Particles was used in the observation group, the course of treatment lasting for 7d. IL-4 and IL-6 were detected by enzyme linked immunosorbent assay(ELISA). After treatment, the clinical efficacy and the changes of IL-4 and IL-6 in the two groups were observed. Results The total effective rate of the observation group was 93.3%(28/30), which was significantly higher than that of the control group 73.3%(22/30), and the difference was statistically significant(P<0.05). The average serum level of IL-4 and IL-6 was lower after treatment in the two groups than before treatment, the difference being statistically significant(P<0.05); in the observation group after treatment, serum level of IL-4 and IL-6 was significantly lower than the control group, the difference being statistically significant(P<0.05). Conclusion The effect of Pediatric Purpura Rash Elimination Particles is remarkable, which may adjust IL-4 and IL-6 levels. Related Articles | Metrics

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Effect of astragalus injection combined with Smecta on immunologic function in children with chronic diarrhea WANG Zhihua 2017, 9 (5):  379-381.  doi: 10.3969/j.issn.1674-3865.2017.05.004 Abstract ( 775 )   PDF (342KB) ( 95 )   Save Objective To investigate the effects of combined treatment with astragalus injection and Smecta on immunologic function in children with chronic diarrhea. Methods Sixty children with chronic diarrhea admitted to Department of Pediatrics, the Second Hospital of Chaoyang from January 2015 to August 2016, were included and equally randomized into treatment group and control group(n=30). Oral treatment with Smecta was given for 10 days in the control group, and the oral treatment with Smecta combined with intravenous injection of astragalus injection was given for 10 days in the treatment group. The treatment efficacy and serum immunoglobulin content after treatment were observed. Results The total effective rate in the treatment group(96.7%,29/30) was significantly higher than that in the control group(73.3%,22/30)(P<0.01). The levels of serum immunoglobulin IgA, IgG and IgM in the two groups after treatment were significantly higher than those before treatment(P<0.05). The levels of serum immunoglobulin IgA, IgG and IgM in the treatment group were significantly higher than those in the control group (P<0.05). Conclusion Combined treatment with astragalus injection and Smecta can improve immunologic function and therapeutic effects in children with chronic diarrhea. Related Articles | Metrics

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Clinical observation of pediatric whooping cough syndrome treated by Baifuyin combined with traditional Chinese medicine injection ZHU Ling，YU Minfeng，LIU Ying，ZHAN Ke，ZHU Weina，ZENG Siyao 2017, 9 (5):  381-395.  doi: 10.3969/j.issn.1674-3865.2017.05.005 Abstract ( 615 )   PDF (631KB) ( 167 )   Save Objective To explore the clinical efficacy of Baifuyin combined with traditional Chinese medicine injection in the treatment of infants and young children with pertussis syndrome. Methods A total of 60 children with whooping cough syndrome were selected from March 2014 to December 2015. By random number table they were divided into observation group(30 cases) and control group(30 cases). The control group was treated with cyclamycin erythromycin dry suspension. The observation group was treated with Baifuyin combined with Xiyanping and/or Chuankezhi injection. Both groups were treated for 14 days. Observe the main symptoms and traditional Chinese medicine syndrome score before and after treatment as well as the clinical efficacy and adverse reactions. Results After treatment， the total scores,the scores of primary and TCM syndromes in the two groups were lower than those before treatment, and the difference was statistically significant(P<0.05). After 7d and 14d of treatment, the abovementioned scores were lower in observation group than in control group; the effective rate and total effective rate of TCM syndrome were significantly higher than those in the control group, and the difference was statistically significant(P<0.05).There was no obvious adverse reaction in the two groups. Conclusion The clinical curative effect of Baifuyin combined with traditional Chinese medicine injection is feasible and safe in the treatment of infants with whooping cough syndrome， which is worthy of clinical application. Related Articles | Metrics

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Expression of S100 A8/A9 protein in children with acute Kawasaki disease and its relationship with coronary artery lesions HU Jing，QIAN Wei，LI Hong，LI Qi 2017, 9 (5):  386-389.  doi: 10.3969/j.issn.1674-3865.2017.05.006 Abstract ( 594 )   PDF (403KB) ( 148 )   Save Objective To investigate the role of S100 A8/A9 protein in the development of Kawasaki disease and the occurrence of coronary artery lesions. Methods A total of 46 children with Kawasaki disease were included as the research subjects, who were treated in Wuxi Children's Hospital from Jan. 2010 to Dec. 2012,and they were divided into two groups based on whether there was coronary artery lesion or not: 20 in the with-lesion group(A) and 26 in the without-lesion group(B). Another 40 children receiving operation for inguinal hernia were chosen as the control group. Peripheral venous blood was collected; the monocytes were separated by stratified fluid density gradient centrifugation of lymphocytes; RNA was extracted; expression of S100 A8/A9 was detected by RT-PCR; the dimer level of plasma S100 A8/A9 was determined by ELISA. Results Before the venous injection of immune globulin for children with acute Kawasaki disease, the dimer level of S100 A8/A9 protein in group A and group B was significantly higher than that in control group, the difference being statistically significant(P<0.05),while after the injection, the expression of S100 A8/A9 mRNA was significantly higher than that in control group, and there was statistical difference(P<0.05);the dimer level of S100 A8/A9 protein and S100 A8/A9 mRNA expression in group A were higher than those in group B, with statistical difference(P<0.05). Conclusion Before venous injection of immune globulin, the S100 A8/A9 mRNA expression and dimer level is significantly higher than the control group, which suggests that S100 A8/A9 may be involved in the pathogenesis of Kawasaki disease. Related Articles | Metrics

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Efficacy of voriconazole in the treatment of invasive pulmonary fungal infection in children with leukernia ZHANG Benshan，WU Pan，HE Shan，SONG Na 2017, 9 (5):  389-391.  doi: 10.3969/j.issn.1674-3865.2017.05.007 Abstract ( 632 )   PDF (364KB) ( 250 )   Save Objective To observe the efficacy and safety of voriconazole in the treatment of invasive pulmonary fungal infection in children with leukemia. Methods Forty-three children with invasive pulmonary fungal infection were randomly divided into observation group(n=22) and control group(n=21).The control group was treated with amphotericin B and the observation group was treated with voriconazole. The clinical efficacy, bacterial clearance and adverse reactions (liver damage, hypokalemia, renal damage, phlebitis and gastrointestinal reactions) were compared between the two groups. Results The total effective rate and bacterial clearance rate of the observation group were 81.8%(18/22) and 86.4%(19/22) respectively, which were significantly higher than those of the control group ［52.4%(11/22),57.1%(12/21)］, the difference being statistically significant(P<0.05). The incidence of adverse reactions in the observation group was 13.6%(3/22), which was significantly lower than that in the control group(42.9%, 9/21), the difference being statistically significant(P<0.05). Conclusion Voriconazole, as a drug for invasive pulmonary fungal infection in children, is safe and effective and deserves to be widely used clinically. Related Articles | Metrics

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Etiological analysis of 78 cases of dyspnea due to non-respiratory diseases ZANG Ping，LUO Lan 2017, 9 (5):  392-394.  doi: 10.3969/j.issn.1674-3865.2017.05.008 Abstract ( 508 )   PDF (349KB) ( 98 )   Save Objective:To analyze the causes of 78 cases of dyspnea due to non-respiratory diseases. Methods:Seventy-eight cases of dyspnea caused by non-respiratory diseases were enrolled， who were hospitalized in the Emergency Department of Hunan Children's Hospital from August 2015 to August 2016. The children underwent laboratory examinations, imaging examinations and echocardiography to determine the cause of the disease and targeted treatment measures were adopted. Results:The main non-respiratory causes resulting in dyspnea included heart failure, thyroid enlargement compressing the trachea and hypothyroidism combined with pericardial effusion, cardiac achalasia, anemia and diabetic ketoacidosis, among which heart failure was the main cause of dyspnea in children, accounting for 65.4%(51/78). After being treated according to the causes of different diseases, the symptoms of dyspnea in children were significantly improved. Conclusion:In the pediatric emergency respiratory problems, there are many non-respiratory reasons, which require doctors to identify through reasonable examination and judgment, so as to take proper treatment measures. Related Articles | Metrics

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Application of bedside cranial ultrasound in the diagnosis of brain injury in premature infants GAO Ang, ZHU Meiying 2017, 9 (5):  394-396.  doi: 10.3969/j.issn.1674-3865.2017.05.009 Abstract ( 545 )   PDF (381KB) ( 128 )   Save Objective To investigate the application value of bedside cranial ultrasound in the diagnosis of premature brain injury. Methods Totally 529 preterm infants with gestational age ≤33 weeks in NICU of Suzhou Municipal Hospital were included from January 2015 to June 2016. All of them were examined by bedside cranial ultrasound, and some of them were also examined by cranial MRI or CT as controls. Results There were 302 cases of brain injury,including 272 cases of intracranial hemorrhage,60 cases of cerebral white matter injury(38 cases of them were combined with different degree of intracranial hemorrhage),and 14 cases of other brain injury diseases. Totally 56 cases of brain injury were detected by MRI or CT in 183 preterm infants|3 cases of subarachnoid hemorrhage and 1 case of subdural hemorrhage were not detected by cranial ultrasound, and the other 52 cases were in accordance with cranial ultrasound report. The detection rate of cranial MRI and CT was 30.60%(56/183). A total of 298 cases of brain injury were detected by cranial ultrasound. The detection rate of bedside cranial ultrasound examination was 56.33%(298/529),which was significantly higher than that of cranial MRI and CT, the difference being statistically significant(P<0.05).The incidence rate of cerebral white matter injury in preterm infants with intracranial hemorrhage was 13.97%(38/272), and that in preterm infants without intracranial hemorrhage was 8.56%(22/257),the difference being statistically significant(P<0.05). Conclusion Brain injury in premature infants is dynamic. The bedside cranial ultrasound has advantages in early screening and dynamic monitoring. Diagnostic accuracy may be improved if it is combined with MRI or CT. Related Articles | Metrics

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Effect of dexamethasone combined with gamma globulin in treatment of children with Henoch Schonlein purpura nephritis and its effect on urinary protein and urine red blood cells LIANG Qundi，ZHANG Cuiping 2017, 9 (5):  397-400.  doi: 10.3969/j.issn.1674-3865.2017.05.010 Abstract ( 850 )   PDF (456KB) ( 214 )   Save Objective To observe the curative effect of dexamethasone combined with gamma globulin in treatment of children with Henoch Schonlein purpura nephritis and its effect on urinary protein and urine red blood cells. Methods A total of 90 cases of allergic purpura treated in our hospital were randomly divided into observation group and control group, 45 cases in each group. The control group was given dexamethasone treatment，and observation group were treated with dexamethasone combined with gamma globulin, four weeks as a course. The clinical efficacy, blood coagulation index before and after treatment, 24h urine protein and urine red cell level and adverse reaction were observed. Results The total effective rate of observation group after treatment was 95.6%(43/45), significantly higher than the control group(77.8%,35/45),the difference being statistical(P<0.05). After 4 weeks of treatment, PT value of both groups had no significant change(P>0.05). APTT was significantly higher in the observation group than in the control group after treatment, while FIB was significantly lower, the difference being statistical(P<0.05). After treatment, the level of 24h urine protein and urine red blood cells was lower than before treatment, and the difference was statistical (P<0.05); the level of 24h urine protein and urine red blood cells of observation group was significantly lower than that in control group, the difference being statistical(P<0.05).The occurrence rate of adverse reaction was 4.4%(2/45) in observation group, and 6.7%(3/45) in control group, there being no difference between the two groups(P>0.05). There was no statistical difference in the occurrence rate of renal damage between the two groups before and 4 weeks after treatment(P>0.05). The follow-up after 3 months of treatment revealed that the rate of renal damage in control group was 28.9%(13/45), significantly higher than that in observation group(11.4%,5/44),in which group one case was lost of follow-up, and the difference was statistical(P<0.05). Conclusion The treatment with dexamethasone combined with gamma globulin has good effect on children with Henoch Schonlein purpura nephritis,which can significantly decrease the level of urine protein and red blood cells and improve the renal function; it has fewer adverse reactions and is worthy of clinical application. Related Articles | Metrics

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Clinical observation on the effect of pidotimod oral liquid on children with bronchial asthma ZHANG Gailing，YU Xiuhong，QI Xiaoping，FENG Bin 2017, 9 (5):  401-403.  doi: 10.3969/j.issn.1674-3865.2017.05.011 Abstract ( 559 )   PDF (355KB) ( 176 )   Save Objective To observe the clinical effect of pidotimod oral liquid on children with bronchial asthma. Methods A total of 120 children with asthma were included as the research subjects, and were randomly divided into two groups: the observation group(60 cases) and the control group(60 cases). The children in both groups were given conventional expectant treatment of oxygen inhalation, relieving cough, eliminating phlegm, and spasmolytic, antiasthmatic and anti-infection therapy; the children in observation group was also treated with pidotimod oral liquid, four weeks as a course for 3 courses. Observe the clinical symptoms, changes in symptoms and lung function, immune function and the clinical effect. Results The total effective rate of observation group was 93.3%(56/60) significantly higher than that of control group(73.3%,44/60),the difference being statistical(P<0.05).After treatment，FEV1, FVC and maximal expiratory flow of observation group were significantly higher than those of control group, and there was statistical difference(P<0.05).The level of CD3+ and CD4+ and CD4+/CD8+ ratio were significantly higher in observation group than in control group after treatment, while CD8+ level was significantly lower, the difference being statistical(P<0.05). Conclusion Pidotimod oral liquid has significant effect in treating children with bronchial asthma; it is safe and can significantly improve the children's immunity, which is worthy of clinical promotion. Related Articles | Metrics

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Study on postoperative recovery of renal morphology and function in children with hydronephrosis caused by stenosis of ureteropelvic junction PENG Qianlong，ZHAO Yaowang，LIU Xiaoqing，YIN Bo 2017, 9 (5):  404-407.  doi: 10.3969/j.issn.1674-3865.2017.05.012 Abstract ( 519 )   PDF (453KB) ( 127 )   Save Objective To observe the postoperative recovery of renal morphology and function in children with hydronephrosis. Methods A total of 85 children were included in the study, who received operation for hydronephrosis caused by stenosis of ureteropelvic junction in Hunan Children's Hospital from Jan. 30, 2013 to June 30, 2016. Observe the clinical effect after operation and determine the long diameter and the anterior and the posterior diameter of pelvis, renal volume and the thickness of renal cortex by B-ultrasound, and the level of serum creatine and urea nitrogen was detected. Results At two weeks after surgery, the thickness of renal cortex at the affected side was significantly increased and became stable at 24 weeks after surgery, and the thickness was significantly higher than that before surgery, the difference being statistical(P<0.05);the renal volume was significantly reduced and became stable at 8 weeks after operation, and comparing the volume at 32 weeks with that before surgery, there was statistically significant difference (P<0.05).At 4 weeks after surgery, the pelvic long diameter was significantly shortened and became stable at 8 weeks,there being statistical difference compared with before operation(P<0.05).After operation, the pelvic anterior and posterior diameter was gradually reduced and became stable at 32 weeks after operation, and there was statistical difference compared with before operation(P<0.05).The level of serum creatine and urea nitrogen after surgery was lower than that before, and the difference was statistical(P<0.05).The total effective rate of renal function recovery in the 85 children with hydronephrosis was 96.47%（82/85) after operation, which proved to be a good recovery. Conclusion There is no change in the postoperative renal volume in children with hydronephrosis; the thickness of the renal cortex, pelvic long diameter, and the morphology of anterior and posterior diameter are obviously improved and become stable with the time passing, which reach the stable state at 6 to 8 months after operation. The renal function and morphology recover well and the clinical effect of operation is excellent. Related Articles | Metrics

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Observation of the curative effect of Nephritis Rehabilitation tablet on hematuria and albuminuria in children with Henoch Schonlein purpura nephritis DING Yunfeng，LI Zhihui，DUAN Cuirong，XUN Li，WU Tianhui，ZHANG Yi 2017, 9 (5):  407-409.  doi: 10.3969/j.issn.1674-3865.2017.05.013 Abstract ( 636 )   PDF (390KB) ( 135 )   Save Objective To observe the efficacy and safety of Nephritis Rehabilitation tablets in treatment of hematuria and proteinuria in children with Henoch Schonlein purpura nephritis. Methods From November 2015 to December 2016, 112 children with Henoch Schonlein purpura nephritis complicated with hematuria and proteinuria were treated in Hunan Children's Hospital, and they were randomly divided into Both groups and the observation group, each with 56 cases. Both groups were given anti-allergy and symptomatic treatment. The observation group was also treated with Nephritis Rehabilitation tablets, 2 weeks as 1 course, and all patients received the treatment for 3 courses. The efficacy and safety of the two groups were compared. Results The total effective rate of observation group was 78.5%(44/56),higher than that of the control group(60.7%，34/56)(P<0.05); in observation group incidence rate of adverse reaction was 19.64%(11/56), significantly lower than the control group(73.21%,41/56)(P<0.05). Conclusion For children with purpura nephritis accompanied by hematuria and proteinuria, the treatment of Nephritis Rehabilitation tablets has significant effect, and it is safe with no obvious toxic and side effects. Related Articles | Metrics

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Clinical effect of Xianfang Chengqi decoction for rectal dripping in the treatment of severe hand-foot-mouth disease encephalitis YANG Puye，LIU Yehong，FU Qingqing，YANG Zhen 2017, 9 (5):  410-413.  doi: 10.3969/j.issn.1674-3865.2017.05.014 Abstract ( 593 )   PDF (535KB) ( 237 )   Save Objective To observe the clinical effect of Xianfang Chengqi decoction in the treatment of severe hand-foot-mouth disease(HFMD) encephalitis. Methods A total of 104 children with HFMD (phase Ⅱ,phase of neurological involvement) were included in the study ,who received treatment in Xi'an Northern Hospital from Mar. 2014 to June 2016,and they were randomly divided into two groups: observation group(n=52) and control group（n=52）.Both groups received symptomatic supportive treatment with antiviral medicine and abatement of fever and fluid infusion. The control group was also given intravenous drip of human immunoglobulin, and the observation group was given rectal dripping of Xianfang Chengqi decoction. After two days of treatment, the clinical effect of the two groups was observed, as well as the time period of gastrointestinal dysfunction, fever, shaking, skittishness, abnormal blood pressure and abnormal heart rate, and the length of hospital stay and adverse reactions. Results The effective rate of observation group was 86.6%（45/52）,significantly higher than that of control group(42.35%,22/52),the difference being statistical(P<0.05).The time period of fever, shaking, being skittish, abnormal blood pressure, abnormal heart rate and hospital stay in the observation group was significantly shorter than that in control group, and there was statistical difference (P<0.05). There were no obvious adverse reactions in both groups. Conclusion Xianfang Chenqi decoction for rectal dripping can inhibit and block the disease in the treatment of severe hand-foot-mouth disease encephalitis. It is significantly effective, safe and easy to operate. Related Articles | Metrics

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Changes of potassium channel protein expression in colon tissue of children with congenital megacolon HUANG Zhao，LI Ming，ZHOU Yuxiang，XIAO Yaling 2017, 9 (5):  413-415.  doi: 10.3969/j.issn.1674-3865.2017.05.015 Abstract ( 535 )   PDF (422KB) ( 143 )   Save Objective To observe the changes of potassium channel protein expression in colon tissue of children with congenital megacolon. Methods Forty patients with congenital megacolon treated in Hunan Children's Hospital from October 2010 to October 2016 were enrolled as the observation group. The 40 patients with intussusception were selected as the control group. The expression of potassium channel protein in colon tissue was measured by immunohistochemistry. Results The positive rate of HERG1 potassium channel protein expression and Kv3.4 potassium channel protein was 85.0%(34/40) and 90.0%(36/40) respectively, which were significantly higher than those of control group［0%, 10.0% (4/40)］, the difference being statistically significant(P<0.05). Conclusion The potassium channel protein of colonic tissue in children with congenital megacolon is characterized by high expression, which may be one important pathogenesis of congenital megacolon. Related Articles | Metrics

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Effect of self made Qingre Qushi Jiedu decoction in the treatment of hand-foot-mouth disease TENG Xing'an 2017, 9 (5):  416-418.  doi: 10.3969/j.issn.1674-3865.2017.05.016 Abstract ( 531 )   PDF (390KB) ( 131 )   Save Objective To observe the clinical effect of Qingre Qushi Jiedu decoction in the treatment of hand-foot-mouth disease. Methods A total of 130 children with hand-foot-mouth disease were included as the research subjects, who were treated in Shidong Health Clinic of Gaolan County, Gansu Province, from Feb.2013 to Dec.2014. These children were randomly divided into two groups, observation group and control group, with 65 cases in each group. Both groups received conventional treatment, and the observation group was also given Qingre Qushi Jiedu decoction, orally taken, for 7 days as a course. Observe the clinical effects in the two groups, as well as the time for fever, food refusal, salivating and herpes to return to normal. Results The effective rate in observation group was 87.7%(57/65)，significantly higher than that of the control group(67.7%,44/65),the difference being statistically significant(P<0.05).The time for fever, food refusal, salivating and herpes to return to normal was significantly shorter in observation group than that in control group, and there was statistical difference（P<0.05）. Conclusion Self made Qing Qushi Jiedu decoction is effective in the treatment of hand-foot-mouth disease, and is worthy of clinical application. Related Articles | Metrics

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Clinical observation of desmopressin acetate combined with birdpecking moxibustion in the treatment of children with primary nocturnal enuresis LYU Yan 2017, 9 (5):  418-420.  doi: 10.3969/j.issn.1674-3865.2017.05.017 Abstract ( 568 )   PDF (403KB) ( 142 )   Save Objective To observe the clinical efficacy of desmopressin acetate combined with birdpecking moxibustion in the treatment of children with primary nocturnal enuresis and its recurrence. Methods A total of 81 cases who were diagnosed as primary nocturnal enuresis were randomly divided into two groups：40 cases were treated with simple acetic acid (control group) and 41 cases were treated with birdpecking moxibustion combined with acetic acid (combined treatment group).The treatment lasted for 6 months. Observe the clinical results and adverse reactions of the two groups. Follow up the recurrence during the 3 months after treatment. Results The total effective rate of combined treatment group was 73.2%（30/41）, and in control group 45.0%（18/40）, there being significant difference between the two groups(P<0.05); the recurrence rate of combined treatment group was 10.0%(3/30), significantly lower than the 44.4%(8/18) of control group, the difference being statistically significant(P<0.05). There were no adverse reactions in both groups. Conclusion Effect of desmopressin acetate combined with birdpecking moxibustion in treating infantile primary nocturnal enuresis is significant with low recurrence rate. There are no significant adverse reactions, so it is worthy of clinical application. Related Articles | Metrics

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Clinical analysis of 42 cases of atypical Kawasaki disease GAN Lumin，LUO Ruping，LIAO Yinan 2017, 9 (5):  421-423.  doi: 10.3969/j.issn.1674-3865.2017.05.018 Abstract ( 556 )   PDF (378KB) ( 122 )   Save Objective To investigate the early clinical manifestations, laboratory findings and treatment of atypical Kawasaki disease. Methods Forty-two patients with a typical Kawasaki disease and 44 cases of typical Kawasaki disease were enrolled in this study, who were treated from May 2013 to July 2015 in Hunan Children's Hospital. The clinical data of the two groups were analyzed. Results The incidence of fever time, rash, chapped lips and chiropractic in children with typical Kawasaki disease was significantly higher than that in children with atypical Kawasaki disease(P<0.05). The incidence of myocardial elevation was significantly higher in children with typical Kawasaki disease than that in children with atypical Kawasaki disease, and the duration of coronary artery changes in the disease course was significantly lower than that in children with atypical Kawasaki disease, the difference being statistically significant(P<0.05). Both of the two groups of children fully recovered, and there were no obvious sequelae or deaths. Conclusion The clinical manifestations of atypical Kawasaki disease are complex and diverse. When the diagnosis of Kawasaki disease is carried out, clinical manifestations laboratory indicators, and children's imaging findings should be considered in the comprehensive analysis to avoid missed diagnosis, misdiagnosis or delayed diagnosis as much as possible, and comprehensive treatment with drugs should be performed as soon as possible. Related Articles | Metrics

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Effects of different doses of continuous infusion of remifentanil on spontaneous respiration of children under sevoflurane anesthesia PENG Tuochao 2017, 9 (5):  424-427.  doi: 10.3969/j.issn.1674-3865.2017.05.019 Abstract ( 484 )   PDF (452KB) ( 207 )   Save Objective To observe the effect of continuous infusion of remifentanil at different doses on spontaneous breathing of children under sevoflurane anesthesia. Methods A total of 126 cases of inguinal hernia repair in Hunan Children's Hospital from January 2016 to December were selected as the research subjects. They were divided into high-dose group and low-dose group by random number table, each with 63 cases. The children inhaled 8% sevoflurane, and the concentration of sevoflurane drugs was lowered when patients were in deep anesthesia; the right type of LM was chosen and the children was given 1 μg/kg intravenous infusion of remifentanil(>1 min) when the concentration of seven halothane of expiratory end was 1.3%. After that, the high-dose group was treated with 0.08 g/kg remifentanil by continuous infusion, and the low-dose group was treated with 0.04 g/kg remifentanil by continuous infusion. The RR,MV,VT and PCO2 at T1(after LM placement), T2(after intravenous transfusion of remifentanil), T3(10 min after continuous infusion), T4(15 min after continuous infusion) and T5(after LM removal) of the two groups were observed. Results The RR and VT of the high-dose group were significantly lower than those of the low-dose group in the period of T3 to T5, the difference being statistically significant(P<0.05). In the T3 and T4 periods, the PCO2 in the high-dose group being significantly higher than that in the low-dose group, the difference being statistically significant(P<0.05). There was no significant difference in VT between the two groups at different time points(P>0.05). Conclusion Sevoflurane combined with 0.04 g/kg remifentanil can effectively improve the ability of spontaneous breathing of children, and meet the clinical needs. It is worthy of clinical application. Related Articles | Metrics

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Clinical effect of recombinant human interferon α-2b spray on herpangina in children YAO Tingxin，LIAO Yinan，GU Fen，YU Sijing，YIN Fei 2017, 9 (5):  427-429.  doi: 10.3969/j.issn.1674-3865.2017.05.020 Abstract ( 1577 )   PDF (425KB) ( 287 )   Save Objective To evaluate the efficacy and safety of recombinant human interferon α-2b(IFN α-2b) spray on herpangina in children, in order to provide scientific evidence for proper administration in pediatrics. Methods A total of 122 children with herpangina at Hunan Children's Hospital and Xiangya Hospital were randomly assigned to two groups: the control group(n=61) treated with ribavirin and conventional therapy,and the observation group(n=61) treated with recombinant human IFN α-2b spray and conventional therapy．The clinical efficacy was evaluate． Results The total clinical effective rate of the observation group was 80.3%（49/61）,significantly higher than the control group(63.9%,49/61）. The defervescence time，oral and pharynx herpes disappearance time and the eating-recovery time in observation group were significantly shorter than those in control group(P<0.05).During the treatment, there were no adverse drug reactions in both groups. Conclusion Recombinant human interferon α-2b spray has significant effect and safety, which can significantly improve the fever course of children with herpangina and shorten the herpes disappearance time and eating-recovery time; there is no adverse reaction. Related Articles | Metrics

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Clinical effect of montelukast sodium and budesonide in children with cough-variant asthma ZHANG Yingxia 2017, 9 (5):  430-432.  doi: 10.3969/j.issn.1674-3865.2017.05.021 Abstract ( 461 )   PDF (347KB) ( 72 )   Save Objective To study the clinical effect of montelukast sodium and budesonide in children with cough-variant asthma. Methods A total of 140 children with cough-variant asthma treated from July 2014 to June 2015 in our hospital were selected. The subjects were divided into two groups according to the different therapies, 70 cases in each group. Group B took budesonide; group A took the combined therapy of montelukast sodium and budesonide; the treatment lasted for 12 days. The clinical effect for two groups was analyzed, and observe the indexes related to pulmonary function:FEV1, PEF and FEV1/FVC. Results The total effective rate of the observation group was 98.6%(69/70), significantly higher than that of control group(77.1%,54/70), and there was statistical difference(P<0.05).Before treatment,there was no statistical difference in such pulmonary indexes as FEV1,PEF or FEV1/FVC between the observation and control group(P>0.05), but after treatment these indexes were significantly higher in the observation group than in the control group with statistical difference(P<0.05). Conclusion The combined therapy of montelukast sodium and budesonide can efficiently improve the clinical effect in the treatment of children with cough-variant asthma, which is worthy of clinical application. Related Articles | Metrics

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Observation on the effects of recombinant human epidermal growth factor in treatment of infantile herpetic gingivitis LIU Furong，LUO Ruping 2017, 9 (5):  432-434.  doi: 10.3969/j.issn.1674-3865.2017.05.022 Abstract ( 513 )   PDF (390KB) ( 124 )   Save Objective To observe the clinical effect of recombinant human epidermal growth factor in the treatment of children with herpetic gingivitis. Methods Totally 60 children with herpetic gingivitis treated in Hunan Children's Hospital from Mar. 2014 to Sep. 2016 were randomly divided into two groups: 30 in control group and 30 in observation group. Both groups were given antivirus treatment with adenosine monophosphate, and the observation group was also given recombinant human epidermal growth factor——Jinyintai spray, which was sprayed in the oral cavity and on gingiva. The treatment lasted for 7 days. Compare the clinical effect, the time of recession of gum swelling and beginning to eat, and the healing time of ulcer and herpes. Results The total effective rate of observation group was 93.3%(28/30), significantly higher than that of control group(73.3%,22/30), and there was statistical difference(P<0.05). All the above-mentioned time was shorter in the observation group, and the difference was statistical(P<0.05). Conclusion Adenosine monophoshate combined with recombinant human epidermal growth factor is better than adenosine monophosphate alone in the treatment of children with herpetic gingivitis, and there is fewer adverse reactions, which is easy for children to accept and worthy of clinical application. Related Articles | Metrics

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Changes and clinical analysis of serum zinc, iron and calcium in malnourished children HE Yi，ZHONG Yan，DING Dawei，YOU Cheng 2017, 9 (5):  435-437.  doi: 10.3969/j.issn.1674-3865.2017.05.023 Abstract ( 649 )   PDF (312KB) ( 134 )   Save Objective To analyze the changes of serum zinc, iron and calcium in malnourished children and its clinical significance. Methods A total of 5 806 malnourished children were treated in Hunan Children's Hospital from January to December of 2016, who were enrolled as the research subjects(malnutrition group),and these children were again divided into 3 groups according to the clinical manifestations: emaciation group(n＝619),growth retardation group(n＝3 918) and reduced body mass group(n＝1 269);another 7 395 healthy children were selected as the control group. The serum zinc, iron and calcium were determined in the two groups. Multi-factor Logistic regression analysis was used to analyze the risk factors in malnourished children. Results The level of serum zinc, iron and calcium of the emaciation group, growth retardation group and reduced body mass group was lower than that of control group with statistical difference(P<0.05). There was no statistical difference in the level of serum zinc, iron and calcium among different types of malnutrition or different age groups or between boys and girls(P>0.05). Multi-factor regression analysis showed that the risk factors for emaciation children were family income, improper feeding and serum iron and zinc; the risk factors for grow-retarded children were the height of fathers and mothers, serum zinc and serum calcium; the risk factors for children with reduced body mass were family income, birth order and serum zinc. Conclusion Child malnutrition is related to the low level of serum zinc, iron and calcium, and the determination of serum zinc, iron and calcium is of great significance. Related Articles | Metrics

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Clinical comparison of different doses of gamma globulin in the treatment of children with immune thrombocytopenia YANG Haixia，ZHENG Mincui 2017, 9 (5):  438-440.  doi: 10.3969/j.issn.1674-3865.2017.05.024 Abstract ( 1170 )   PDF (331KB) ( 98 )   Save Objective To observe and analyze the clinical efficacy of different doses of gamma globulin in the treatment of children with immune thrombocytopenia. Methods A total of 94 children with immune thrombocytopenia who were treated in our hospital from November 2014 to December 2016 were randomly divided into low-dose group(n＝47) and conventional-dose group(n＝47). Both groups of children were treated with dexamethasone. The low-dose group was treated with 200 mg/(kg·d) gamma globulin. The conventional-dose group was treated with 400 mg/(kg·d) gamma globulin,once a week for one month. Observe the following items: clinical effect, duration of platelet increase, time of platelet rising to normal level, peak time of platelet, coagulating time of platelet, hospital stay, treatment expense, WBC count, hemoglobin, platelet count and the incidence of adverse reactions. Results There was no statistical difference in the total effective rate between the two groups(P>0.05). There was no statistical difference in duration of platelet increase, time of platelet rising to normal level, coagulating time of platelet or hospital stay(P>0.05) between the two groups. There was no statistical difference in WBC count or hemoglobin(P>0.05) between the two groups(P>0.05). After treatment, the platelet count was significantly higher in low-dose group than in conventional-dose group and there was statistical difference(P<0.05). The peak time of platelet was significantly shorter in low-dose group than in conventional-dose group with statistical difference(P<0.05). The treatment expense was also less in the conventional-dose group and there was statistical difference(P<0.05). There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion The effect and safety of these two doses of gamma globulin is similar in the treatment of children with immune thrombocytopenia; however, the low-dose treatment results in shorter peak time of platelet with less expense, so it is worthy of clinical application. Related Articles | Metrics

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Effect of enema reset with normal saline under B-ultrasound in the treatment of children with acute indigitation LI Xiaodong, ZHAO Guojin 2017, 9 (5):  441-443.  doi: 10.3969/j.issn.1674-3865.2017.05.025 Abstract ( 576 )   PDF (288KB) ( 197 )   Save Objective To study the effect of enema reset with normal saline under B-ultrasound in the treatment of children with acute indigitation. Methods A retrospective analysis was performed on the clinical data in 98 children with acute indigitation, who were treated in our hospital from Jan. 2013 to Jan. 2016.They were divided into two groups based on the treatment protocol: control group(n＝38) and observation group(n＝60).The control group was treated by enema reset with air under X-ray, and the observation group received normal saline for enema reset under B-ultrasound. The treatment duration, exhausting time after operation, length of hospital stay, body temperature and CRP were compared between the two groups. Results The treatment duration, exhausting time after operation, length of hospital stay, body temperature and CRP of the observation group were all better than those of the control group, and there was significant and statistical difference（P<0.05）. Conclusion The effect of enema reset with normal saline under B-ultrasound is significant in the treatment of children with acute indigitation, which is worthy of clinical application. Related Articles | Metrics

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Effect of continuous nursing on daily living ability in children with cerebral palsy LIU Aibin 2017, 9 (5):  443-445.  doi: 10.3969/j.issn.1674-3865.2017.05.026 Abstract ( 459 )   PDF (384KB) ( 132 )   Save Objective To study and discuss the effect of continuous nursing on daily living ability in children with cerebral palsy. Methods Totally 100 children with cerebral palsy were selected as the study subjects, who received treatment in Shenyang Children's Hospital from Oct. 2014 to Oct. 2015. The patients were randomly divided into the control group and the observation group, 50 cases in each group. After being discharged from the hospital, the control group received routine nursing care, and the observation group received continuous nursing care. The two groups were followed up for a period of 6 months, Barthel index and cerebral palsy scale score was compared at two time points: on discharge and 6 months after discharge. Results At 6 months after discharge, the Barthel index and cerebral palsy scale score were higher compared with those on discharge, and the difference was statistical(P<0.05), and the index and score of the observation group were significantly higher than those of the control group, the difference being statistical(P<0.05). Conclusion The continuous nursing care for children with cerebral palsy after discharge can effectively improve the ability of daily living activities. Related Articles | Metrics

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Clinical value of urine HBsAg detection in the annual health examination of 2 031 children LYU Guangxiu,ZHOU Juan,CAO Yong 2017, 9 (5):  446-448.  doi: 10.3969/j.issn.1674-3865.2017.05.027 Abstract ( 623 )   PDF (364KB) ( 154 )   Save Objective To investigate the application value of HBsAg detection in urine. Methods A total of 2 031 pupils were included as the research subjects，980 of whom were from an urban elementary school and 1 051 from suburban school. Urine sanguinis was taken on Monday morning at the second week of a term. HBsAg in urine was detected by ELISA, and those with positive HBsAg testing were detected the hepatitis-B-related indexes. Results In the 980 from the urban school, one had slightly positive HBsAg, which was proved to be negative in the reexamination at a special hospital. In the 1 051 from the suburban school, 5 had positive HBsAg, and after the blood testing in a special hospital,4 were HBsAg carries, and one had positive HBsAg, HBeAg and HBcAb, and all the 5 pupils had normal liver function. Conclusion Urine HBsAg test can be a way of screening for people with HBsAg infection. Hepatitis B vaccine can protect our health, so we should receive vaccination in time as scheduled. Related Articles | Metrics

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Investigation of head MRI and TCM syndromes in children with cerebral palsy GAO Shan，GUAN Lijun 2017, 9 (5):  448-450.  doi: 10.3969/j.issn.1674-3865.2017.05.028 Abstract ( 396 )   PDF (418KB) ( 198 )   Save Objective To study the head MRI manifestations and the TCM syndrome types in children with cerebral palsy. Methods A total of 156 children with cerebral palsy were selected, who were treated in Shenyang children's Hospital from Jan. 2014 to Dec. 2016.According to TCM syndrome differentiation, there were 93 cases of strong-liver and weak-spleen type(59.62%), 22 cases of spleen-kidney deficiency type(14.10%), 15 cases of phlegm and blood stasis type(9.62%),and heart-spleen weakness type(16.67%) . The head of these children was examined by MRI, and the relationship between MRI manifestations and TCM syndrome types was analyzed. Results In the 156 cases of cerebral palsy, there are 64 cases of leucomalacia(41.02%), 41 cases of extra-cerebral interval widening(26.28%), 6 cases of lateral ventricular lesion(3.84%),19 cases of basal ganglia lesion(12.18%), 16 cases of malformation of myelin sheath(10.26%), 3 cases of malformation of brain development(1.92%), and 7 cases of corpus callosum lesion(4.49%). The manifestations of head MRI had statistical difference in various TCM syndromes(P<0.05), and there were more cases of leucomalacia and cerebral interval widening in the strong-liver and weak-spleen syndrome than in other syndrome types(P<0.05). Conclusion There is an internal relationship between the MRI manifestations and TCM syndrome types in children with cerebral palsy. Related Articles | Metrics

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Study on the clinical types and complications of 1 323 cases of infantile cerebral palsy QU Di，GUAN Lijun 2017, 9 (5):  451-454.  doi: 10.3969/j.issn.1674-3865.2017.05.029 Abstract ( 563 )   PDF (464KB) ( 149 )   Save Objective To study the clinical types complications of children with cerebral palsy. Methods From January 2013 to October 2016, we investigated the clinical types and complications of 1 323 cases of children with cerebral palsy between the ages of 3 and 14 in Liaoning province. Results Spastic type was the most common type of cerebral palsy, followed by low-tension type, involuntary-movement type, mixed type and dystaxic type. There was statistical difference in the clinical types among children at different ages(P<0.01).There was statistical difference in the incidence of complications among different types of cerebral palsy(P<0.05).Except for the complication of hearing impairment, there was statistical difference in the incidence of complications in difference types of cerebral palsy(P<0.05). The incidence of mental retardation was highest in the mixed type, and then spastic type, dystaxic type, low-tension type and involuntary-movement type. Visual and hearing impairment occurred most often in the dystaxic type the incidence of language disorder, convulsion or epilepsy and abnormal behavior was most common in the mixed type. Conclusion The incidence of mental and language retardation is highest in various clinical types of cerebral palsy, and these types are internally related to complications. Related Articles | Metrics

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Impact of environmental tobacco smoke on the control of pediatric asthma FENG Qingguo,LING Wanli,TANG Jiandong,HONG Yi 2017, 9 (5):  454-456.  doi: 10.3969/j.issn.1674-3865.2017.05.030 Abstract ( 482 )   PDF (428KB) ( 133 )   Save Objective To explore the impact of environmental tobacco smoke on control of pediatric asthma. Methods A total of 80 children with mild to moderate bronchial asthma, who were first diagnosed in Changshu TCM Hospital from Jan. 2012 to Dec. 2012,were divided into two groups: no-exposure group(no smokers in the family, and visitors stopped smoking at their house,38 children),and exposure group(there were family members who smoked in their house,42 children).These children received standardized treatment after being diagnosed according to the Guideline to Diagnosis and Treatment of Pediatric Bronchial Asthma. They were required to visit doctors respectively at one month,3 months and 6 months after first diagnosis, and complete the questionnaire of child asthma control test(C-ACT).Compare the C-ACT scores between the two groups after 6 months of treatment. Results The complete control rate of exposure group was 47.6%(20/42) after 6 months of treatment, significantly lower than that of no-exposure group(76.3%，29/38)，the difference being statistical(P<0.05). Conclusion Environmental tobacco smoke has a significant impact on pediatric asthma control. Avoiding exposure to environmental tobacco smoke is the key to the prevention and cure of pediatric asthma. Related Articles | Metrics

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Clinical manifestation and gene analysis of multiple acyl-coa dehydrogenase deficiency with transaminase increase TAN Yangfang, OUYANG Wenxian, JIANG Tao, TANG Lian,SU Yuxia,LI Shuangjie 2017, 9 (5):  456-458.  doi: 10.3969/j.issn.1674-3865.2017.05.031 Abstract ( 442 )   PDF (506KB) ( 173 )   Save Objective:To study the clinical manifestations of the patients with multiple acyl-coa dehydrogenase deficiency with transaminase increase, the laboratory tests, muscle biopsy and gene mutations, and to review the literature in order to provide the evidence for the early diagnosis and treatment of the disease. Methods;Collectthe clinical data of a boy aged 7 years and 3 months, and take the blood samples of the child and his parents. The second-generation gene sequencing was used to detect the pathogenic gene, and gastrocnemius muscle biopsy was used to find out the muscle condition. Results:The electron microscopic results of the muscle biopsy showed that there was a lot of lipid droplets in the myofiber. The gene sequencing results showed that there were nonsense mutation of c.1773＿1774 del AT p.(Cys592※) and missense mutation of c.389A＞T p.(Asp130Val) in ETFDH genes of the child, which was considered to be complex heterozygous mutation. The parents were the carriers. Conclusion:Clinically there are people with transaminase increase complicated with increase of myocardial enzymes and movement disorders, in whom molecular genetic examinations should be performed as soon as possible. The patients with suitable conditions should be given gastrocnemius muscle biopsy, which can provide accurate hereditary consultation and prenatal diagnosis for the family of the patient. Related Articles | Metrics