Table of Content

25 February 2017, Volume 9 Issue 1 Previous Issue    Next Issue

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Clinical observation on Jianyi decoction in the treatment of asthmatic children in remission stage with syndrome of deficiency of lung and spleen qi LIU Fang,ZHANG Xinguang，WU Yahui,LI Meihua,YU Jianer 2017, 9 (1):  1-4.  doi: 10.3969/j.issn.1674-3865.2017.01.001 Abstract ( 531 )   PDF (577KB) ( 154 )   Save Objective: To evaluate the clinical efficacy of Jianyi decoction(JYD) in the treatment of asthmatic children with syndrome of deficiency of lung and spleen qi. Methods: Totally 80 children with asthma in remission stage from February 2015 to April 2016 were divided into control group and observation group. The control group(40 cases) were given Pulmicort neblizing treatment. The observation group(40 cases) were treated with Chinese medicine Jianyi decoction. The score change of major symptoms and signs as well as the clinical effect between the two groups were observed after 6-month treatment. Results: The total effective rate was 87.5% in observation group, which had no statistical difference from control group(P>0.05); the observation group was superior to control group in improvement of main symptoms and signs with statistical significant difference(P<0.05). Conclusion: The treatment of administration of JYD for asthmatic children with syndrome of deficiency of lung and spleen qi is effective. It is worthy of clinically spreading. Related Articles | Metrics

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Bushen Gubiao prescription combined with Huangqin Kechuan plaster powder in the treatment of children with recurrent respiratory infection: a clinical observation on the effect WANG Pan,XU Wanchao,ZHU Huahe,LIU Yazun,XUE Zheng 2017, 9 (1):  5-8.  doi: 10.3969/j.issn.1674-3865.2017.01.002 Abstract ( 608 )   PDF (486KB) ( 189 )   Save Objective: To observe the effect of Bushen Gubiao prescription combined with Huangqin Kechuan plaster powder in the treatment of children with recurrent respiratory infection. Methods: A total of 90 children with recurrent respiratory infection, who visited  Shanghai TCM Hospital between May and July of 2015, were collected and they were randomly divided into 3 groups: internal treatment group(A), external treatment group(B) and combined internal and external treatment group(C), 30 children in each group. Group C was given Bushen Gubiao prescription combined with Huangqin Kechuan plaster powder for treatment; group B was treated with Huangqin Kechuan plaster powder in summer; group A was given Bushen Gubiao prescription for internal taking. The treatment lasted for 6 weeks. Observe the daily symptom scores of the children before and after treatment and the clinical effect; detect the sIgA level abnormalities in the saliva of children. Results: The clinical effective rate was 56.7%(17/30) in group C, which was significantly higher than that in group B(16.7%,5/30) and group A(23.3%,7/30), with statistical difference(P<0.017). In the treatment of abnormal diet and abnormal bowel movement, the daily symptom scores of group B were higher than those of group C and group A, with statistical difference(P<0.05); in the treatment of abnormal sweating, the scores of group C were lower than group A and B, and there was statistical difference(P<0.05). The rate of abnormal saliva sIgA in group C was 54.2%(13/24), significantly lower than that of group B(90.5%,19/21), the difference being significantly statistical(P<0.017). Conclusion: Internal treatment with Bushen Gubiao prescription, external treatment with Huangqin Kechuan plaster powder, and the combined treatment of the above two are all effective in recurrent respiratory infection, and the combined therapy is better than the other two therapies Related Articles | Metrics

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Diagnosis and prescription laws in treating Clostridium difficile-associated diarrhea by traditional Chinese medicine and the literature analysis LIU Xinzhu, Wang Jun, GUO Yanan 2017, 9 (1):  9-15.  doi: 10.3969/j.issn.1674-3865.2017.01.003 Abstract ( 632 )   PDF (713KB) ( 435 )   Save Objective: To explore and study the diagnosis and prescription laws in treating Clostridium difficile-associated diarrhea by traditional Chinese medicine, in order to provide reference for clinical treatment of CDAD. Methods: We searched CNKI, WanFang, and other databases, literatures of both traditional Chinese medicine and integrated traditional Chinese and Western medicine in treating CDAD, which were published in the past 10 years, were collated and analyzed. We conducted statistical analysis of the therapeutic principle, frequency of use, efficacy, potency and taste of a single herb. Results: The top three treatment were related to strengthening spleen, invigorating Qi and removing dampness, accounting for 52%. Atractylodes, licorice, codonopsis, Chinese yam and white beans were chosen to strengthen spleen and invigorating Qi; Poria cocos and coix seeds were chosen to induce diuresis and eliminate dampness; Fructus amomi and herb were chosen to remove dampness. In treating CDAD, drugs to strengthen spleen, induce diuresis and eliminate dampness were more frequently used, accounting for 53.6%. From the point of view of drug potency, warm and flat drugs accounted for 65.7%. As for the smell and taste, sweet and bitter drugs accounted for 59.5%. In summary, drugs associated with treating spleen, stomach and lung accounted for 60.4% of all drugs used in treating CDAD. Conclusion: The main principle of treatment for CDAD is to strengthen spleen, invigorate Qi and remove dampness. Herbal prescription should focus on warm and flat herbs, with sweet and bitter smell to go through the spleen, stomach and lung. Related Articles | Metrics

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Research progress of animal model of anorexia LI Han, XIONG Lei, CHEN Bojun,XIE Yuhuan,ZHOU Yingqing, HUANG Yucheng 2017, 9 (1):  15-18.  doi: 10.3969/j.issn.1674-3865.2017.01.004 Abstract ( 595 )   PDF (556KB) ( 531 )   Save Anorexia is a common disease of unusual ingestive behavior of human, and building animal model is helpful to the intensive study of this disease. The related report on anorexia modeling method is little in China, and there is insufficiency of animal model which is used in anorexia experimental study, which is related to heredity, mentality, physiology, environment and other factors. This paper makes an analysis on the common anorexia modeling method both at home and abroad and its advantage and disadvantage, and points out the current problems which exist in the process of developing and evaluating the TCM animal model. Related Articles | Metrics

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Meta-analysis of three classic herbal prescriptions treatment for acute exacerbation of asthma in children XU Jing，LI Jianbao 2017, 9 (1):  19-22.  doi: 10.3969/j.issn.1674-3865.2017.01.005 Abstract ( 537 )   PDF (1183KB) ( 167 )   Save Objective: To systematically evaluate the clinical effect of Dingchuan decoction, Maxingshigan decoction and Xiaoqinglong decoction in the treatment of children with asthma. Methods: Search the CNKI and make a Meta-analysis by using RevMan 5.3 software. Results: Totally 13 RCTs were included into the study. The Meta-analysis results showed that each of the three kinds of prescription combined with conventional western medicine treatment was superior to routine treatment with western medicine. Conclusion: Traditional Chinese medicine has a good curative effect in the treatment of childhood asthma in acute exacerbation. However, the quality of literature is still lower in this study, so the treatment with traditional Chinese medicine for children asthma needs to be tested with more rigorous experiments. Related Articles | Metrics

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Clinical observation on umbilical therapy combined with ultrashort wave therapy for infantile acute mesenteric lymphadenitis ZHAO Jingjing，ZHUANG Cheng，SHEN Yiyun 2017, 9 (1):  22-24.  doi: 10.3969/j.issn.1674-3865.2017.01.006 Abstract ( 460 )   PDF (418KB) ( 178 )   Save Objective: To observe the effect of umbilical therapy combined with ultrashort wave on acute mesenteric lymphadenitis in children. Methods: Sixty-four children with acute mesenteric lymphadenitis admitted to the 7th People 's Hospital from October 2015 to October 2016 were randomly divided into the control group(32 cases) and the observation group(32 cases). Treatment lasted for 5 days. The control group was treated with ribavirin granules, and the treatment group was treated with umbilical therapy and ultrashort wave therapy in addition to the treatment for control group. After one course of treatment, the curative effect was evaluated. Results: The clinical efficacy of the observation group(96.9%,31/32) was better than the control group(71.9%,23/32), and the difference was statistically significant(P<0.05); in observation group after treatment, high-frequency color Doppler ultrasound showed the size of mesenteric lymph node was smaller than the control group, and the difference was statistically significant(P<0.05). Conclusion: Umbilical with ultrashort wave therapy has significant effect in children with acute mesenteric lymphadenitis, which is worth promoting. Related Articles | Metrics

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Risk factors of high-risk infants in neonatal period and their correlation with the gestational age XU Chao, HUANG Yan, CUI Zhenze，CHENG Xian 2017, 9 (1):  25-28.  doi: 10.3969/j.issn.1674-3865.2017.01.007 Abstract ( 449 )   PDF (506KB) ( 224 )   Save Objective: To explore the possible mechanism of the risk factors of high risk infants in the neonatal period by analyzing the incidence of risk factors and correlation between risk factors and gestational age in neonatal period of high-risk infants. Methods: A total of 1 800 high-risk neonates were admitted to Dalian Children's Hospital for treatment form June 2012 to June 2013. Totally 1 000 neonates were randomly chosen, among whom 780 were during the neonatal period. IMOCH High-risk Scoring for Infants was used and combined with the case record during hospital stay, the risk factors were collected. Results: The incidence of high-risk infants in the neonatal period was 78%. The percentage of risk factors from high to low (over 10%) was neonatal infectious disease(Pneumonia, etc. 51.28%), less than 37 weeks of gestation(47.56%), neonatal pathological jaundice（22.69%）, respiratory cyanosis in the neonatal period（22.43%）, excited scream in the neonatal period（18.08%）, abnormal hearing screening（14.62%）, and hypoxic-ischemic encephalopathy（12.05%）. Single factor(33.29%) and combination of two factors(32.53%) were most common. Hypoxic-ischemic encephalopathy, convulsions and excited scream in the neonatal period had positive correlation with the gestational age of high-risk infants（P＜0.05）. Respiratory cyanosis in the neonatal period had negative correlation with the gestational age of high-risk infants（P＜0.05）. Conclusion: The risk factors of high-risk infants in the neonatal period are various, and they interact with each other; some of these factors were also closely related to the gestational age. Related Articles | Metrics

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Endoscopic and clinical features of 215 cases of pediatric Henoch-Schonlein purpura with digestive tract symptoms TANG Shuo, YOU Jieyu, LIU Li 2017, 9 (1):  29-32.  doi: 10.3969/j.issn.1674-3865.2017.01.008 Abstract ( 563 )   PDF (453KB) ( 125 )   Save Objective: To study the endoscopic and clinical features of Henoch-Schonlein purpura(HSP) in children with digestive tract symptoms. Methods: Analyze the clinical features of 215 children with HSP in our hospital and summarize endoscopic results of 119 children who took gastroscopy. According to severity of mucosa damage under endoscopy, the children were divided into two groups. The total time of abdominal pain, the time of abdominal pain after admission, the hospital stay, the rate of pancreatitis and HSPN were compared between the two groups, and the high risk factors of severe mucosal damage were analyzed. Results: The major digestive clinical manifestations of HSP were abdominal pain, emesia and hematochezia; abdominal pain was found as the first-onset symptom in 90 cases (41.9%). No significant difference was observed in the total time of abdominal pain and rate of pancreatitis between the two groups(P＞0.05). Significant differences was observed in the time of abdominal pain after admission, the hospital stay and the rate of HSPN between the two groups (P＜0.05). The rate of renal damage was of statistical significance in the risk factors of HSP children with severe digestive mucosa damage. Conclusion: Abdominal pain can be the first-onset symptom. The endoscopic results of HSP in children can help to make the diagnosis. The severity of mucosa damage under endoscopy of HSP in children is not correlated with the total time of abdominal pain or the rate of pancreatitis, but is significantly correlated with the time of abdominal pain after admission, the hospital stay and the rate of HSPN. The risk factor associated with severe mucosa damage in HSP is renal damage. Related Articles | Metrics

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Effect observation of self-made Erchuanning decoction in treating capillary bronchitis BAI Chenyan 2017, 9 (1):  33-35.  doi: 10.3969/j.issn.1674-3865.2017.01.009 Abstract ( 399 )   PDF (355KB) ( 112 )   Save Objective: To investigate the clinical effect of self-made Erchuanning decoction in treating capillary bronchitis. Methods: Totally 100 cases with capillary bronchitis in our hospital from October 2013 to October 2015 were selected and divided into observation group and control group, 50 cases in each group. Control group was given conventional treatment, including Shuchuanling and Ventolin inhalant. Observation group was given Erchuanning decoction，7 days as a course. After two courses, compare the clinical effect between the two groups, and the fever, asthma, cough, lung wheezing sound disappearing time of the two groups. Results: Total effective rate of observation group(86.0%,43/50) was obviously higher than that of control group(60.0%,30/50), the difference being statistically significant(P<0.05). Fever, asthma, cough, lung wheezing sound disappearing time of observation group was shorter than that of control group, the difference being statistically significant(P<0.05). Conclusion: Erchuanning decoction in treating capillary bronchitis has significant effect, which can improve condition of child patients, significantly shorten treatment time and is worthy of clinical application. Related Articles | Metrics

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Effect of tanshinone ⅡA combined with naloxone on nerve injury in neonates with hypoxic-ischemic encephalopathy SUN Honghua 2017, 9 (1):  35-37.  doi: 10.3969/j.issn.1674-3865.2017.01.010 Abstract ( 516 )   PDF (371KB) ( 134 )   Save Objective: To investigate the effects of the combined use of tanshinone ⅡA and naloxone on nerve injury in neonates with hypoxic-ischemic encephalopathy. Methods: Sixty-six neonates with hypoxic-ischemic encephalopathy were equally randomized into tanshinone ⅡA plus naloxone,naloxone,and control groups.The conventional symptomatic treatment was given to the neonates in the three groups;the neonates in tanshinone ⅡA plus naloxone and naloxone groups were respectively given combined treatment for 10~14 days or naloxone treatment alone for 5~7 days. Neurological scores were assessed at birth and at the end of treatment, and the serum levels of neuron specific enolase were determined. Results: Compared with before treatment,the neurological scores were increased to different degrees,while the serum neuron specific enolase levels were decreased after treatment;those changes were the most obvious in the combined treatment group(P<0.01).After treatment,the neurological scores were the highest,while the serum neuron specific enolase levels were the lowest in the combined treatment group compared with the other two groups(P<0.01). Conclusion: The use of tanshinone ⅡA plus naloxone in the treatment of hypoxic-ischemic encephalopathy can significantly attenuate nerve injury. Related Articles | Metrics

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Analysis of clinical characteristics of severe traumatic brain injury caused by accident ZHANG Jing，XIONG Qunli，LIU Pingdong 2017, 9 (1):  38-40.  doi: 10.3969/j.issn.1674-3865.2017.01.011 Abstract ( 432 )   PDF (375KB) ( 114 )   Save Objective: To study the clinical characteristics and treatment of severe traumatic brain injury caused by accident in children. Methods: A total of 49 cases of children with severe traumatic brain injury treated in Yangang Hospital in Yantian District of Shenzhen City from February 2015 to February 2016 were selected and divided into the observation group, with 30 cases whose Glasgow coma index(GCS, Glasgow Coma, Scale) was 5 or less, and the control group, with 19 cases whose Glasgow coma index(GCS, Glasgow Coma, Scale) was more than 5. The mortality, survival rate and complications were compared between the two groups. Results: The survival rate of the observation group was significantly higher than that of the control group, and the differences were statistically significant(P<0.05), and at the same time, the incidence of complications in the observation group was 20%(6/30), which was lower than 57.89%(11/19) in the control group and the differences were statistically significant(P<0.05). Conclusion: In clinical application, the GCS score, pupil and consciousness are key factors to determine the condition of the disease in the diagnosis of children with severe traumatic brain injury. Further strengthening the monitoring of intracranial pressure and taking effective measures in time can help reduce the mortality rate and improve survival rate. Related Articles | Metrics

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Infection situation of Mycoplasma pneumoniae in small infants with spastic cough and its treatment analysis WANG Jiangtao，WANG Xiaoling，LIU Rong 2017, 9 (1):  40-43.  doi: 10.3969/j.issn.1674-3865.2017.01.012 Abstract ( 532 )   PDF (503KB) ( 472 )   Save Objective: To understand the infection status of mycoplasma pneumonia in 1-3-month children with spastic cough and analyse effect of macrolide drugs on spastic cough. Methods: A total of 235 cases of whooping cough syndrome in children were hospitalized for treatment from January 2015 to August 2016 in Zhengzhou Children's Hospital to different pathogens: Mycoplasma pneumoniae infection group(A，33 cases), non-Mycoplasma pneumoniae infection group(B,103 cases) and unknown pathogen group(C,99 cases). Direct immunofluorescence assay was used to detect the 7 common respiratory pathogenic antibodies. ELISA was performed to determine the titer of Mycoplasma pneumoniae antibodies in the serum at acute stage and recovery stage. Blood Agar was used to perform sputum bacteria culture. The children in group A and B were given cephalosporin and macrolides antibiotics, while those in group C were given cephalosporins, the treatment lasting 7 days. Observe the time for the spasmodic cough to disappear and the clinical effect in the children who came to hospital within 7 days of disease onset and after 7 days. Results: The pathogens of whooping cough syndrome were mostly viruses and bacteria; the detection rate of Mycoplasma pneumoniae was 14.04%(33/235).The spasmodic cough lasted for (5.79±0.89) days in the children visiting hospital within 7 days and their average hospital stay was (10.25±1.66) days, both of which were lower than the children who visited hospital for treatment 7 days after disease onset ［(10.38±2.00) days,(13.75±1.49) days］, and the difference being significant(P<0.05). The total effective rate in the 3 groups was respectively 93.94%(31/33), 91.26%(94/103) and 79.80%(79/99), and there was statistical difference(P<0.05). Conclusion: The pathogens of whooping cough syndrome are mostly viruses and bacteria. It can shorten the time of spasmodic cough and average hospital stay to visit hospital early, make early diagnosis and perform effective treatment. Cephalosporins are very effective in the treatment of whooping cough syndrome in small babies, but their abuse should be avoided. Related Articles | Metrics

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Observation of clinical effect of Bifid Triple Viable Capsules Dissolving at Intestines combined with smecta in treatment of infantile diarrhea LIU Weiping, LIAO Chaoping, CHEN Yanli 2017, 9 (1):  44-46.  doi: 10.3969/j.issn.1674-3865.2017.01.013 Abstract ( 501 )   PDF (373KB) ( 437 )   Save Objective: To observe the effect of Bifid Triple Viable Capsules Dissolving at Intestines combined with smecta in treatment of infantile diarrhea. Methods: Totally 98 cases of children with diarrhea who accepted treatments in Gangtou Community Health Service Center of Central Hospital of Longhua District of Shenzhen City from September 2014 to January 2016 were randomly divided into observation group and control group, with 49 cases in each group. The control group received routine therapy, while the observation group, on the basis of the treatment for the control group, were treated with the Bifid Triple Viable Capsules Dissolving at Intestines combined with smecta. Then, after 1 week of treatment, the treatment effect, recovery time and adverse reaction of two groups of patients were observed. Results: The total effective rate in the observation group was 91.8%(45/49), which was higher than the control group(75.5%, 37/49), and the difference was statistically significant(P<0.05). The recovery time of body temperature, stool frequency and stool character in the observation group was shorter than that in the control group, the difference being statistically significant(P<0.05). There was no serious adverse reaction in the two groups. Conclusion: The clinical effects of Bifid Triple Viable Capsules Dissolving at Intestines combined with smecta in treatment of infantile diarrhea are significant, which can quickly control the disease, reduce the pain of children, and the safety is high, thus it can be used as the preferred drug treatment for children with diarrhea. Related Articles | Metrics

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Clinical observation on the treatment for bronchiolitis in children with Bairui granules and atomization GUO Aili, ZHU Weiwei, ZHU Jie, QIU Liyun 2017, 9 (1):  46-48.  doi: 10.3969/j.issn.1674-3865.2017.01.014 Abstract ( 758 )   PDF (410KB) ( 122 )   Save Objective: To evaluate the clinical effects of Bairui granules and atomization in the treatment of bronchiolitis in children. Methods: From November 2015 to January 2016,84 cases of capillary bronchitis in Jinan Central Hospital were randomly divided into observation group(42 cases) and control group(42 cases), and they were all treated with budesonide and terbutaline inhalation and symptomatic treatment. The observation group was added Bairui granules. After 7 days of treatment, the treatment effect as well as the time of cough relief and the time for dyspnea and pulmonary wheezing rales to disappear of each group was recorded. Results: The total effective rate of the observation group was 95.23%(40/42), which was higher than that of the control group(71.42%,30/42), the difference being statistically significant. The time of cough relief  was shorter in observation group than in control group, with statistical difference(P<0.05). Conclusion: Bairui granules have obvious effect in treatment of children with bronchiolitis and is worthy of clinical application. Related Articles | Metrics

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Clinical effects of Fuganlin oral solution on bronchiolitis with phlegm-heat closing lungs LI Ran,SUN Yanhong 2017, 9 (1):  49-52.  doi: 10.3969/j.issn.1674-3865.2017.01.015 Abstract ( 683 )   PDF (485KB) ( 84 )   Save Objective: To observe the clinical effects of Fuganlin oral solution on bronchiolitis with phlegm-heat closing lungs. Methods: Between April 2015 and March 2016,106 cases were diagnosed as bronchiolitis with phlegm-heat closing lungs in our hospital; they were randomly divided into 2 groups. The control group(52 cases) was treated with intravenous ribavirin and budesonide and ventolin inhalation. The treatment group(54 cases) was given Fuganlin oral solution besides routine therapy. The treatment lasted for 7 days. The treatment results were compared. Results: On the 3rd day, the symptoms of cough, sputum, and fever in observation group were improved markedly compared with the control group(P<0.05); on the 5th day, the effective rates of all symptoms were higher than the control group except for fever(P<0.05). Conclusion: The Fuganlin oral solution combined with routine therapy is an effective and safe treatment for the children with bronchiolitis with phlegm-heat closing lungs. Related Articles | Metrics

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Clinical diagnosis and treatment of infants with CMV infection ZHU Ke，WANG Jiangtao 2017, 9 (1):  52-54.  doi: 10.3969/j.issn.1674-3865.2017.01.016 Abstract ( 1010 )   PDF (404KB) ( 132 )   Save Objective: To observe the clinical characteristics,diagnosis and treatment of infantile cytomegalovirus(CMV)infection. Methods: From Oct.2014 to Oct.2016,72 children with CMV infection were admitted to the Infant Department of Zhengzhou Children′s Hospital.Serum CMV-IgM was detected by enzyme-linked immunosorbent assay(ELISA),and the children whose level of CMV-DNA-PCR was higher than that of normal group by PCR fluorescent probe were found. The 72 cases of children were given ganciclovir treatment, and the treatment was divided into induction therapy and maintenance therapy. The following examinations were performed: routine blood test, liver and kidney function, chest X-ray, cerebral CT, brainstem auditory evoked potential and ultrasonography. Meanwhile, the CMV-DNA-PCR of mothers were detected, and its clinical manifestations and diagnosis and treatment were analyzed. Results: The clinical manifestations included infantile hepatitis in 45 cases, hyperbilirubinemia in 35 cases, pneumonia in 31 cases, brain injury in 18 cases, brainstem auditory evoked potential abnormality in 9 cases, malnutrition in 6 cases, congenital heart disease in 5 cases and hereditary metabolic diseases in 3 cases. The milk CMV-DNA-PCR of 45 mothers was higher in the 60 mothers of breast feeding. Totally 65 cases were improved or cured after treatment, and 7 cases gave up treatment. Conclusion: Small infants are prone to CMV infection, and the clinical manifestations are various, with hepatobiliary system abnormalities most common. For children diagnosed with CMV infection, CMV-DNA-PCR of mother's milk should be detected simultaneously and early intervention should be performed. Ganciclovir antiviral treatment produces good prognosis in most cases, and early diagnosis and treatment is helpful to improve the prognosis. Related Articles | Metrics

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Triple therapy for children with functional dyspepsia complicated by positive Helicobacter pylori infection: an observation on the effect WU Xia，WANG Shengguang 2017, 9 (1):  55-57.  doi: 10.3969/j.issn.1674-3865.2017.01.017 Abstract ( 675 )   PDF (382KB) ( 115 )   Save Objective: To observe the effect of triple therapy for children with functional dyspepsia complicated by positive Helicobacter pylori(Hp) infection. Methods: From Mar. 2014 to Mar. 2016, a total of 116 children with functional dyspepsia complicated by Hp infection were hospitalized for treatment in Xili Children's Hospital of Nanshan District in Shenzhen City, who were randomly divided into two groups: observation group(58 cases) and control group(58 cases). The control group was given domperidone orally taken, and for the observation group, triple therapy(omeprazole+clarithromycin+amoxicillin) was performed in addition to the treatment for the control group, 10 days as a treatment course. Observe the clinical effect, Hp eradication after treatment and the adverse reactions in the two groups. Results: The total effective rate of observation group was 91.4%(53/58), higher than that of the control group 74.1%(43/58), the difference being statistical(P<0.05). The Hp eradication rate in observation group was 94.8%(55/58), significantly higher than that in the control group(51.7%,30/58) and there was statistical difference(P<0.01). There was no statistical difference on the rate of adverse reactions between the two groups during treatment(P>0.05). Conclusion: Triple therapy is quite effective and safe in the treatment of children with functional dyspepsia complicated by positive Hp infection, and should be clinically used. Related Articles | Metrics

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Combined traditional Chinese and western medicine along with early rehabilitation training for neonatal hypoxic ischemic encephalopathy ZHAO Shulin，WEI Lifang 2017, 9 (1):  57-60.  doi: 10.3969/j.issn.1674-3865.2017.01.018 Abstract ( 568 )   PDF (529KB) ( 149 )   Save Objective:To observe the clinical effect of integrated traditional Chinese and Western medicine and early rehabilitation training in the treatment of neonatal hypoxic ischemic encephalopathy. Methods:Totally 152 cases of hypoxic ischemic encephalopathy were randomly divided into treatment group and control group, 76 cases in each group. In the early stage, oxygen inhalation, sedation, dieresis, intracranial pressure reduction, control of seizures and other symptomatic support therapies were given in both of the groups. In the stable stage, patients in the control group were given cerebroprotein hydrolysate for injection and monosialo four hexose ganglioside injection. In the treatment group, besides cerebroprotein hydrolysate for injection and monosialo four hexose ganglioside injection, patients were given traditional Chinese medicine treatment based on pattern differentiation and early rehabilitation training. NBNA was performed on 3 d,14 d and 28 d respectively and compare the NBNA of the two groups before and after treatment. Intelligence development was determined respectively at 3,6,9,12 and 18 months. Observe and compare the clinical effect in the two groups after treatment. Results:The total effective rate was 92.1% in the treatment group, and 78.9% in the control group, the difference of which was statistically significant (P<0.05).The NBNA was significantly improved in the two groups after treatment, and the difference was of statistical significance(P<0.05). The NBNA was higher in the observation group than in the control group with statistical difference(P<0.01). After treatment the development score was significantly improved in both groups, and there was statistical difference compared with that before treatment(P<0.01),the score improvement was more significant in the observation group,the difference being statistically significant(P<0.01). Conclusion:The combination of traditional Chinese and Western medicine and early rehabilitation training is effective in the treatment of neonatal hypoxic ischemic encephalopathy. Related Articles | Metrics

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Clinical analysis of infantile convulsion and its prevention strategies LI Aiyue 2017, 9 (1):  61-64.  doi: 10.3969/j.issn.1674-3865.2017.01.019 Abstract ( 464 )   PDF (423KB) ( 220 )   Save Objective:To discuss the causes of infantile convulsion, clinical features, incidence trend and prevention strategies. Methods:A retrospective analysis was performed on the clinical data of 1 058 cases of infantile convulsion admitted to our hospital between January 2013 and December 2015. Results:Among 1 058 cases of infantile convulsion, the ratio of male to female was 1.4∶1,the average onset age was (3.0±1.6) years, and the peak incidence appeared between the age of 1 and 3.In the three years, the proportion of children visiting hospital for infantile convulsion was increasing. The attack of the disease came in almost every season; especially during the second quarter and the fourth quarter, there was an increasing trend（P<0.05）.Among the 1 058 cases, there are 820 children(77.5%) suffering from infant febrile convulsion, among which there are 626 cases(59.2%) of simple convulsion and 194 cases(18.3%) of complex febrile convulsion. The most common risk factors of febrile convulsion were virus infection, vaccination and positive family history. The five most common infectious diseases and their proportions in child patients were as follows: acute upper respiratory infection(30%),acute tonsillitis(25.5%), herpangina(10.6%), bronchial pneumonia(3.2%) and exanthema subitum(3.2%).Among these causes, febrile convulsion, acute gastroenteritis with benign convulsion and intracranial infection were the main causes of convulsion before the age of six; after six, the main cause was epilepsy. Conclusion:In the three years, the number of infantile convulsion has been increasing, and the causes of infantile convulsion are not only diverse but also complex. Therefore, it is significant to build family intervention strategies to reduce brain damage. Related Articles | Metrics

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Analysis of the clinical value of budesonide inhalation therapy for neonatal pneumonia LI Di 2017, 9 (1):  65-67.  doi: 10.3969/j.issn.1674-3865.2017.01.020 Abstract ( 426 )   PDF (354KB) ( 178 )   Save Objective:To observe the clinical value of budesonide inhalation therapy for neonatal pneumonia. Methods:A total of 98 cases of neonatal pneumonia were treated in Anshan Maternal and Children's Hospital from Oct. 2010 to Nov. 2012, and they were divided into two groups: 52 cases in observation group and 46 cases in control group. The routine treatment was given to the control group，while for the observation group, budesonide inhalation therapy was also performed besides routine treatment; the treatment lasted for 1 week. Compare the treatment results between the two groups, and carbon dioxide partial pressure, oxygenation index, dyspnea, time of pulmonary rales disappearing and length of hospital stay were also compared before and after treatment. Results:The total effective rate of observation group was 96.2%(50/52), which was higher than that of the control group 80.4%(37/46), and there was statistical difference(P<0.05). After treatment, the CO2 partial pressure in observation group was lower than that in control group, while oxygenation index was higher, both differences being statistical(P<0.05). Number of dyspnea, time of pulmonary rales disappearing and length of hospital stay of observation group were all lower than those of control group, and the difference was statistical(P<0.05). Conclusion:Routine treatment combined with budesonide inhalation can significantly improve the clinical symptoms of neonates with pneumonia, which increases the clinical effect and helps to achieve a better prognosis. Related Articles | Metrics

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Analysis of children's hand-foot-mouth disease treated by children's soybean granule combined with ribavirin aerosol YU Sijing 2017, 9 (1):  67-69.  doi: 10.3969/j.issn.1674-3865.2017.01.021 Abstract ( 559 )   PDF (419KB) ( 132 )   Save Objective:To explore the clinical effect of soybean granule combined with ribavirin aerosol for children with hand-foot-mouth disease(HFMD). Methods:A total of 78 children with HFMD, who were treated in our hospital from February 2015 to February 2016, were randomly divided into observation group and control group(39 cases in each group). The patients in the control group were treated with aerosolized ribavirin. The patients in the observation group were treated with the combination of children's soybean granules and ribavirin aerosol. Seven days after treatment, the effect in the two groups of pediatric patients, the corresponding clinical signs and symptoms and the adverse reactions were compared. Results:The total effective rate was 97.44% in the observation group and 82.05% in the control group. The total effective rate in the observation group was significantly higher than that in the control group(P<0.05). The time of fever subsidence, the time of rash disappearance and the recovery time were shorter in the observation group than in the control group. There was significant difference between the two groups (P<0.05). The adverse reaction rate was 2.56% in the observation group and 23.08% in the control group. There was a significant difference between the two groups(P<0.05). Conclusion:The treatment for pediatric hand-foot-mouth disease with the combination of pediatric soybean granules and ribavirin aerosol have a high efficacy and a low incidence of clinical adverse reactions, with high safety and convenient and simple administration. It should be promoted in clinical treatment. Related Articles | Metrics

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Electroacupuncture combined with mouse nerve growth factor acupoint injection in treatment of children with peripheral facial paralysis:a clinical research LIU Chunlei, WANG Paoqiu, LUO Wei, HUANG Chao, TAN Longze 2017, 9 (1):  70-73.  doi: 10.3969/j.issn.1674-3865.2017.01.022 Abstract ( 447 )   PDF (492KB) ( 90 )   Save Objective:To study and analyze the clinical effect of electroacupuncture combined with mouse nerve growth factor acupoint injection in treatment of children with peripheral facial paralysis. Methods:Eighty children treated in Hunan Children's Hospital for peripheral facial paralysis from June 2015 to June 2016 were included as the research subjects, and they were randomly divided into two groups: the observation group and control group, with 40 cases in each group. The children in the control group were treated with electroacupuncture, continuously for 6 days with 1 day rest, 7 days as a treatment course, for 3 courses. The children in the observation group were treated with mouse nerve growth factor acupoint injection in addition to the treatment for control group, 3 time a week as one course, for 3 courses. Before and after treatment, SFGS was used to evaluate the effect. Results:Before and after treatment, SFGS score had statistical difference within each group(P<0.05). After treatment, the score of observation group was significantly higher than that of control group(P<0.05). After treatment, some facial nervous functions were improved a lot in both groups, such as mimetic muscle paralysis, facial distortion and air blow and leak. The effect in the observation group was much better than that in the control group with statistical difference(P<0.05). Conclusion:Electroacupuncture combined with mouse nerve growth factor acupoint injection is better than the conventional acupuncture in the treatment of children with peripheral facial paralysis. It can improve the facial nervous function of children, which is of clinical significance. Related Articles | Metrics

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Influence of continuous improvement in nursing quality on vaccination behavior in preschool children HU Ying, XU Zhiping, MO Minli, HU Sujun 2017, 9 (1):  73-76.  doi: 10.3969/j.issn.1674-3865.2017.01.023 Abstract ( 469 )   PDF (624KB) ( 279 )   Save Objective:To study the influence of continuous improvement in nursing quality on vaccination behavior in preschool school. Methods:A total of 120 children were included as the research subjects, who were vaccination in the Second People's Hospital of Futian District in Shenzhen from Oct. 2015 to mar. 2016, and they were randomly divided into two groups: the observation group(60 cases) and the control group(60 cases). The control group was given routine nursing for vaccination, while the observation group was given nursing intervention guided by the mode of continuous improvement in nursing quality. Compare the parents' understanding about vaccination, their vaccination-related behavior, their satisfaction about nursing and the children's cooperation during vaccination. Results:The parents' understanding about vaccination , their vaccination-related behavior and their satisfaction about nursing in the observation group were significantly better than those of the control group , and the children's cooperation level was significantly higher than the control group, the difference being statistical (P<0.05). Conclusion:Continuous improvement in nursing quality can not only significantly improve parents' understanding about vaccination and their satisfaction about nursing, it can also modify the vaccination-related behavior; besides, the children's co-operation level is significantly increased. Related Articles | Metrics

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Evaluation on the effect of nursing intervention for inguinal hernia in children GUO Lanbing 2017, 9 (1):  77-79.  doi: 10.3969/j.issn.1674-3865.2017.01.024 Abstract ( 377 )   PDF (410KB) ( 130 )   Save Objective:To observe the effect of nursing intervention for inguinal hernia in children. Methods:Sixty children with inguinal hernia were selected from the Fifth People's Hospital of Shenyang from June 2014 to June 2016, and randomly divided into the control group and the observation group. Children in the control group were given routine nursing, while children in the observation group were given special nursing based on routine nursing, and their immediate family members received health guidance. The intensity of pain was evaluated at 0,1,2,3,4 and 5 hours after operation between two groups. Satisfaction rates of patients' families were compared between two groups. Results:There was no significant difference between two groups in the intensity of pain at 0 hour after operation. The intensity of pain of observation group was lower than that of the control group at 1,2,3,4 and 5 hours after operation. There was no significant difference between two groups in informing attentions and responding to calling. The other aspects of satisfaction rates of observation group were higher than those of the control group. Conclusion:The integrated management model which includes immediate family participation in health guidance can alleviate pediatric postoperative pain effectively, and is worth spreading. Related Articles | Metrics

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Clinical analysis of the disease spectrum of acute respiratory tract infections in children in Baoji area and its preventive measures WEI Shengyun，TANG Shubin，ZHANG Hui，PANG Weibin，WANG Li 2017, 9 (1):  80-84.  doi: 10.3969/j.issn.1674-3865.2017.01.025 Abstract ( 557 )   PDF (508KB) ( 124 )   Save Objective:To analyze the diagnosis of disease spectrum in children with acute respiratory tract infections in Baoji and preventive health care measures. Methods:The clinical date of the children hospitalized for respiratory infection in Baoji Children's Hospital from January to December of 2015 were downloaded from the His system of the hospital, including age, gender, locating of lesion and the diagnosis and prognosis. Results:There were totally 8 595 cases of respiratory infection, accounting for 57.9%(8 595/14 842) of all the children hospitalized in the hospital in 2015, among which 23.6%(2 029/8 595) were acute upper respiratory infection, 76.4%(6 566/8 595) lower. Among those with lower infection,23.1%(1 983/8 595) were with tracheal and bronchial involvement; there were 4 583 cases of infancy pneumonia, accounting for 53.3%(4 583/8 595). The occurrence rate of upper and lower respiratory infection was different in each age group; the peak age of onset was between 3 months and 1 year. The hospitalization rate of those with lower respiratory infection was 3.2 times of that of those with acute upper respiratory infection. Acute respiratory infection was also the first cause of death in Baoji, accounting for 38.7% of all the causes of death(12/31), and 32.3%(10/31) of the children died of neonatal pneumonia and severe pneumonia. Conclusion:Respiratory infection is the first cause of hospitalization in children of Baoji. The disease spectrum is various, with the peak between 3 months and one year old. The hospitalization rate for lower respiratory infection is much higher than that for acute upper infection. Pneumonia is still the first cause of death in children in Baoji. It's better to do a good job in prevention and healthcare of children of all ages and to improve diagnosis and treatment level in order to reduce the occurrence rate of acute respiratory infection, increase the success rate and decrease the death rate. Related Articles | Metrics

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Investigation of the fatigue symptoms in children with ALL during chemotherapy REN Wei，WANG Jianli，LI Sijing，ZHANG Zhihong，WU Yumei,LI Ruidan，CHANG Xiaodan，SHI Caixiao 2017, 9 (1):  84-87.  doi: 10.3969/j.issn.1674-3865.2017.01.026 Abstract ( 575 )   PDF (455KB) ( 130 )   Save Objective:To investigate the fatigue symptom of children with acute lymphoblastic leukemia(ALL)during chemotherapy. Methods:Totally 216 children with ALL in Pediatric Hematology Departments of Children's Hospital in Zhengzhou City and their parents were investigated by questionnaire. According to chemotherapy stage, these children were divided into 3 groups: first therapy group(68 cases),non-first group(88 cases), and the interval group(60 cases), and they were surveyed by using Chinese version of Peds QLTM multidimensional fatigue scale. Results:The total score of the fatigue symptom of children with ALL during chemotherapy was （33.19±23.17）.Average score of general fatigue was （11.94±7.59）.Average score of sleeping fatigue was（11.80±7.70）.Average score of cognitive fatigue was（9.45±7.88）.There was significant difference among different phases of chemotherapy（P＜0.05）. Conclusion:Fatigue symptom is common in children with ALL, and score of general fatigue and sleeping fatigue is at average level, and the score of cognitive fatigue is below average level. Fatigue symptom of children with ALL are different during chemotherapy．Medical staff should evaluate symptoms of fatigue and provide targeted management of symptoms. Related Articles | Metrics

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Experiences of Dachengqi decoction in treating children with sweating disease of stomach-burning type ZHANG Xiaobo，SHI Huijuan 2017, 9 (1):  88-90.  doi: 10.3969/j.issn.1674-3865.2017.01.027 Abstract ( 497 )   PDF (454KB) ( 1059 )   Save Sweat is one of the products of human metabolism, which is commonly seen in hot weather or due to too much clothing or violent activities sweating disease in children is an abnormal disease, which is believed to be mainly deficiency syndrome in the traditional Chinese medicine concept. Excess syndrome is also observed in clinical practice and the type of stomach heat burnings more common. Giving priority to Dachengqi decoction in the treatment based on syndrome differentiation is utilized in the clinic. The effect is remarkable. Here is a test case. Related Articles | Metrics