Table of Content

25 August 2022, Volume 14 Issue 4 Previous Issue    Next Issue

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A case of Gaucher disease type Ⅱ caused by glucocererosidase gene compound heterozygous mutations WANG Mengru, LI Jianqin 2022, 14 (4):  277-279.  doi: 10.3969/j.issn.1674-3865.2022.04.001 Abstract ( 404 )   PDF (409KB) ( 66 )   Save Objective To analyze the clinical characteristics and genetic features of Gaucher disease that is rare clinically. Methods The related clinical data and the results of whole exons gene testing of a 10-month patient with anemia in our hospital were retrospectively analyzed. Results The patient was female，who presented with anemia，hepatosplenomegaly，laryngomalacia and growth and development retardation.It was found through testing that there were two heterozygous mutation in glucocererosidase(GBA) gene:c.588+1G>A(splicing) and c.1448T>C(p.L483P)，which came from her parents. Conclusion Gaucher disease type Ⅱ is an acute neurological Gaucher disease with the onset at infancy，which is a rare type.The disease is usually presented as anemia，hepatosplenomegaly，development regression，and growth and development arrest.It is often complicated with acute nervous damage，and its clinical features and genetic analysis are of great significance in confirming the diagnosis. Related Articles | Metrics

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Atypical GM2 ganglioside storage syndrome caused by HEXA gene mutation:a case report and literature review ZHANG Yong, ZHAI Hongyin, CUI Wenzhe, GUO Zhikuan 2022, 14 (4):  280-283.  doi: 10.3969/j.issn.1674-3865.2022.04.002 Abstract ( 575 )   PDF (900KB) ( 74 )   Save Objective To improve the understanding of GM2 ganglioside storage syndrome caused by HEXA gene mutation.Methods The clinical manifestations，laboratory examinations and genetic diagnosis of GM2 ganglioside storage syndrome in one child were analyzed retrospectively.Meanwhile，domestic and foreign literatures were reviewed，and the incidence，clinical manifestations，diagnosis，current treatment methods and prognosis of the disease were summarized. Results The child had mental motor development regression，auditory hypersensitivity，abnormal muscular tone and active tendon reflexes.Medical whole exons detection showed that the subject carried HEXA gene heterozygous variation，the mother carried c.546dupA(p.L183Tfs*3) heterozygous variation，and the father carried c.611A >G (p.H204R) heterozygous variation.Massage therapy and functional training were given for two months，and the symptoms were improved.Conclusion Clinically GM2 ganglioside storage syndrome is very rare，and patients often have mental motor development regression，hyperacusis and fundus cherry erythema，so it is relatively hard to make early clinical diagnosis.Leucocyte β-hexosaminidase and genetic testing is helpful for diagnosis. Related Articles | Metrics

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Pediatric acute myocardial pericarditis similar to acute myocardial infarction: clinical analysis of one case and literature review ZHU Yunyi, QIN Jiacheng, SHEN Yi, CHENG Chao 2022, 14 (4):  284-287.  doi: 10.3969/j.issn.1674-3865.2022.04.003 Abstract ( 383 )   PDF (2152KB) ( 50 )   Save Objective To explore the early differentiation between pediatric acute myocardial pericarditis and acute myocardial infarction. MethodsAnalyze the clinical manifestations, myocardial markers and electrocardiographic characteristics of a case of pediatric acute myocardial pericarditis similar to acute myocardial infarction and make a literature review.Results It was found that pediatric acute myocardial pericarditis and acute myocardial infarction had similar clinical manifestations and electrocardiogram ST-T elevation， but were different in the risk factors and coronary angiography.Conclusion The early identification of pediatric acute myocardial pericarditis and acute myocardial infarction can be made according to the detailed inquiring medical history, electrocardiographic evolution characteristics and coronary angiography. Related Articles | Metrics

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Advances on the pathogenesis and therapeutics of familial male-limited precocious puberty JIANG Chenyan, YU Jian 2022, 14 (4):  288-292.  doi: 10.3969/j.issn.1674-3865.2022.04.004 Abstract ( 640 )   PDF (596KB) ( 168 )   Save Familial male-limited precocious puberty (FMPP) is mainly caused by activating mutations of luteinizing hormone/choriogonadotropin receptor (LHCGR) gene.Many mutations have been identified，but the relationship between genotypes and phenotypes is not completely clear.The main therapeutic purpose of FMPP is to inhibit pubertal development，decrease the excessively high level of sexual hormone and delay the early closure of epiphysis in order to improve the adult height.There are several major categories of clinical drugs for FMPP，including gonadal steroidogenesis inhibitors，antiestrogen，cytochrome P450 inhibitors，and aromatase inhibitors.FMPP is a rare disease.Although there are some reports on single or combined clinical applications of the above drugs and their adverse reactions，multi-centered and large-sample systematic studies are still in need. Related Articles | Metrics

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Treatment for daytime frequent urination syndrome in children based on "one-breath circulation"JI Cong ZHAI Wensheng, HE Mei, REN Xiangge 2022, 14 (4):  292-295.  doi: 10.3969/j.issn.1674-3865.2022.04.005 Abstract ( 460 )   PDF (604KB) ( 214 )   Save Daytime frequent urination syndrome is one of the common diseases in children，which is characterized by a significant increase in the requency of urination during the day，without fever，pain or other discomfort.Modern medicine believes that the occurrence of the disease may be related to the immature development of the central nervous system in children.Mental tension is an important inducing factor.The main treatment is to alleviate the frequency of urination，and cholinergic receptor antagonists are often used.Relapse often occurs after drug withdrawal and there are many side effects.In addition，daytime frequent urination syndrome is often misdiagnosed as urinary tract infection，resulting in the abuse of antibiotics.Traditional Chinese medicine is effective in the treatment of the disease.Huang Yuanyu was one of the famous doctors in Qing dynasty，whose main academic thought is "circulation of one qi".The theory emphasizes that the rise and fall of middle qi is in the core position of the human body，and in physiology，spleen ascending and stomach falling results in wood fire rising and floating，gold water converging and falling，water and fire intersecting and yin and yang harmonizing;pathologically，if qi is in disorder，diseases will arise.Based on this theory，the incidence of daytime frequent urination syndrome is related to earth deficiency，wood depression and water coldness.The movement of body fluid is weak due to the deficiency of middle earth;the body fluid doesn′t circulate actively because of wood depression in the left side;the body fluid can′t be transformed due to water coldness in the right side;the deficiency and decline of middle yang is the main pathogenesis.Therefore，the principles of treatment are to warm middle earth，regulate liver，and warm Kidney to recover the circulation of one qi so that the body fluid moves in harmony and frequent urination is cured. Related Articles | Metrics

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Study on "Tongluo" technology in the treatment of children with spastic cerebral palsy based on "five body constituents of five internal organs" XU Wenya, LI Ruishi, HE Si, FENG Zhaocai 2022, 14 (4):  296-299.  doi: 10.3969/j.issn.1674-3865.2022.04.006 Abstract ( 564 )   PDF (613KB) ( 151 )   Save Cerebral palsy(CP) is currently one of the most common disabling disease in children.Although brain damage no longer progress，the secondary musculoskeletal lesions because of it are the important causes of the clinical manifestations such as dyskinesia and abnormal posture，which is also the focus of treatment.The "Tongluo" technology is the acupuncture and moxibustion and massage commonly used in the pediatric rehabilitation department of our hospital，which can improve the muscular tension of children with spastic CP and increase the clinical effect on motor function.This article discusses the mechanism of action of "Tongluo" technology regarding the five aspects of tendons，vessels，muscles，skin and bones，corresponding to the five internal organs in TCM，with the aim that this technology can be used more scientifically and properly in clinic Related Articles | Metrics

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Efficacy and safety of early use of erythropoietin for neuroprotection in premature infants: a Meta-analysis TANG Liang, CHEN Xiaoqing, TAN Weiqiang 2022, 14 (4):  300-307.  doi: 10.3969/j.issn.1674-3865.2022.04.007 Abstract ( 627 )   PDF (2287KB) ( 156 )   Save Objective To systematically evaluate the efficacy and safety of early use of erythropoietin(EPO) for neuroprotectionin premature infants. Methods PubMed, Embase, The Cochrane Library, CBM, CNKI, WanFang Data and VIP databases were searched through computers to collect randomized controlled trials(RCTs) on EPO for neuroprotection in premature infants, the searching time being from inception to December,2020.RevMan 5.3 software was used for Meta-analysis. Results A total of 16 RCTs involving 3 650 premature infants were included. The results of meta-analysis showed that low-dose EPO could increase the mental development index(MDI)［MD=7.26，95%CI(2.99，11.53)，P=0.000 9］ and the psychomotor development index(PDI)［MD=4.88，95%CI(1.76，7.99)，P=0.002］ in the infants at adjusted age of 12 to 24 months， and it could reduce the incidence of MDI<70［MD=0.41,95%CI(0.27, 0.64),P<0.000 1］, but the effect of high-dose EPO（≥1 000 U/kg） treatment showed no difference between treatment group and control group(P>0.05). Compared with the control group, the incidence of cerebral palsy, hearing impairment, visual impairment and other neurodevelopmental disorders in the EPO group were not statistically different(P>0.05). EPO could reduce the incidence of necrotizing enterocolitis, intraventricular hemorrhage（Ⅲ/Ⅳ） and periventricular leukomalacia, without increasing the risk of bronchopulmonary dysplasia and retinopathy in prematurity（≥Ⅲ）.Conclusion Low-dose EPO treatment at an early stage can improve the neurodevelopmental outcomes of premature infants and is safe, but the effect of high-dose EPO needs further study.Due to limited quality and quantity of the included studies, more high quality studies are required to verify the above conclusions.  Related Articles | Metrics

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Relationship of hormone and vitamin D levels with obesity in preschool obese children CHEN Guochun, LUO Cuimei, ZHANG Quanshan, XIE Chunhua 2022, 14 (4):  308-312.  doi: 10.3969/j.issn.1674-3865.2022.04.008 Abstract ( 623 )   PDF (498KB) ( 41 )   Save Objective To explore the relationship between the levels of hormones and vitamin D and obesity in obese preschool children.Methods A total of 128 preschoolers who met the diagnostic criteria for obesity were selected as research subjects. According to the serum vitamin D level, they were divided into appropriate vitamin D group(n=42), insufficient vitamin D group(n=53) and deficient vitamin D group(n=33). The glucolipid metabolism level, vitamin D,Gn, T3, T4 and parathyroid hormone levels of the three groups were compared and analyzed, and the correlation between vitamin D level and the levels of glucolipid metabolism and various hormones levels was analyzed by Person method.Results The levels of FBG, TC, HDL-C, Gn, T3, T4 and parathyroid hormone in vitamin D deficiency group were lower than those in appropriate group and insufficiency group, while the levels of TG and LDL-C were higher(P<0.05). There was a significant correlation between the vitamin D level of deficiency group and insufficiency group and the glucolipid metabolism indexes of children and the levels of T3, T4 and parathyroid hormone (P<0.05), but there was no significant correlation with glucolipid metabolism indexes of children in the appropriate vitamin D group(P>0.05).Conclusion Vitamin D levels in deficiency and insufficiency groups of children are correlated with glucolipid metabolism and hormone levels. Related Articles | Metrics

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Evaluation of the effect of combined detection of LDH, PCT and ADA in cerebrospinal fluid in children with different types of central nervous system infections ZHANG Xiaofang, XIE Haizhen 2022, 14 (4):  312-315.  doi: 10.3969/j.issn.1674-3865.2022.04.009 Abstract ( 459 )   PDF (553KB) ( 82 )   Save Objective To investigate the effect of the combined detection of lactate dehydrogenase(LDH), procalcitonin(PCT) and adenosine dehydrogenase(ADA) in evaluating different types of central nervous system infections in children.Methods A total of 92 children with central nervous system infection admitted to our hospital from March 2019 to March 2021 were selected and divided into bacteria group(52 cases) and virus group(40 cases) according to different types. In the same period, 60 children with migraine without central nervous system infection were selected as the control group. Compare the levels of LDH, PCT and ADA among the three groups, find out the best cut-off values of bacterial meningitis and viral meningitis in the above-mentioned cerebrospinal fluid indexes based on the receiver operating characteristic(ROC) curve, and then analyze the area under the ROC curve(AUC) under separate and combined detection of LDH, PCT and ADA. Results The levels of LDH, PCT and ADA in the bacteria group were higher than those in the virus group, and the difference was statistically significant(P<0.05); the levels of LDH, PCT and ADA in the virus group were higher than those in the control group, and the difference was statistically significant(P<0.05). LDH, PCT, and ADA were used to complete single and multiple tests on children in the bacteria and virus groups. It was found that the best cut-off values of the above indicators when tested separately were 25.95 U/L,1.89 μg/L and 0.87 U/L, respectively.The AUC of LDH, PCT and ADA for combined diagnosis of children with bacterial meningitis was significantly greater than the AUC of the individual diagnosis, and the difference was statistically significant(P<0.05).Conclusion For the diagnosis of bacterial meningitis and viral meningitis, the combined detection of LDH, PCT and ADA in the tandem mode has higher application value. Related Articles | Metrics

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Value of combining surface electromyography with video EEG and ECG in the diagnosis of motor seizures in children with epilepsy LYU Pin 2022, 14 (4):  316-318.  doi: 10.3969/j.issn.1674-3865.2022.04.010 Abstract ( 702 )   PDF (374KB) ( 107 )   Save Objective To study the value of combining surface EMG with video EEG and electrocardiogram in the diagnosis of motor seizures in children with epilepsy.Methods Totally 142 children suspected with epilepsy were treated in the Department of Neurology of our hospital from April 2019 to October 2020，all of whom showed recurrent motor seizures，and they were included as research subjects.All the children were examined by surface electromyography，video EEG and electrocardiogram，and the diagnostic results were counted.Results Among the 142 children who were examined，82 were diagnosed with epilepsy;the diagnosis accuracy of pure video EEG was 91.46%(75/82)，which was lower than that of the combined diagnosis (100.0%，82/82)，there being a statistically significant difference(P<0.05).For different types of motor seizures，the onset period and seizure interval of video EEG had typical characteristics，and the synchronous ECG showed the accelerated heart rate at seizures;the surface EMG duration and ECG duration of four different seizure types were within 10 s，and the difference was not statistically significant(P>0.05);motor seizure was synchronized with EMG and ECG.Conclusion The combined monitoring of surface EMG，video EEG and ECG is helpful to detect early epilepsy in children，accurately distinguish the types of motor seizures，and guide clinical treatment. Related Articles | Metrics

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A randomized controlled multicenter clinical study of Shanpu Jianpi granules in the treatment of children with functional dyspepsia LI Binxi, WANG Xuefeng, TAN Chunying, MENG Bin, ZHANG Xiuying, WANG Yawen, LI Zhuo 2022, 14 (4):  319-322.  doi: 10.3969/j.issn.1674-3865.2022.04.011 Abstract ( 736 )   PDF (511KB) ( 139 )   Save Objective To evaluate the effect of Shanpu Jianpi granules in improving the symptoms of functional dyspepsia and stagnation of spleen deficiency in children, and the safety of its clinical application.Methods  A randomized, controlled, multicenter, non-inferiority test design method was used. A total of 120 children with functional dyspepsia who were admitted to the First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning Maternal and Child Health Hospital, and Benxi Manzhou Autonomous County Traditional Chinese Medicine Hospital from February 2022 to July 2022 were chosen and randomly divided into the observation group and the control group with 60 cases in each group. The observation group was given oral administration of Shanpu Jianpi granules, while the control group was given oral administration of Bifidobacterium triple viable enteric-coated capsules. The treatment lasted for 2 weeks. After the treatment course, record the following: (1) the comprehensive total effective rate of functional dyspepsia symptom scores in the two groups; (2) the curative effect of TCM syndromes in the two groups (total effective rate); (3) the curative effect of a single symptom of functional dyspepsia in the two groups; (4) the incidence of adverse reactions in the two groups.Results  The comprehensive total effective rate of functional dyspepsia symptom in the observation group and the control group was89.83%(53/59) and 85.96(49/57), suggesting that the observation group was not inferior to the control group. There was no statistical difference in other minor indexes between the two groups, including effect on traditional Chinese medicine syndrome and the curative effect on single symptom of functional dyspepsia (P>0.05). Altogether 3 adverse events were reported, one in the observation group (1.69%，1/59) and two in the control group (3.51%,2/57), and there was no statistical difference in the incidence of adverse events between the two groups. Conclusion Shanpu Jianpi granules is not inferior to the control drug Bifidobacterium triple viable enteric-coated capsules in the treatment of FD symptoms, and can improve TCM syndromes, with good clinical safety. Related Articles | Metrics

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Risk factors of myocardial damage in children with Mycoplasma pneumoniae pneumonia SU Yonghong, SUN Xueli, YANG Lili, YAN Wenjuan, WU Chunlian 2022, 14 (4):  323-325.  doi: 10.3969/j.issn.1674-3865.2022.04.012 Abstract ( 713 )   PDF (405KB) ( 81 )   Save Objective To investigate the related influencing factors of Mycoplasma pneumoniae pneumonia(MPP) complicated with myocardial damage. Methods A total of 126 children diagnosed with MPP in the Department of Pediatrics of Weifang Maternal and Child Health Care Hospital from January 2018 to January 2020 were selected as the research subjects.According to whether they were complicated with myocardial injury，they were divided into observation group(MPP complicated with myocardial injury，66 cases) and control group(without complication with myocardial injury，60 cases).The general data of the subjects were collected，and the heat duration，heat peak，chest X-ray results，length of hospital stay，and age of onset were observed to learn about the main influencing factors of myocardial damage in children with MPP.Results (1) Univariate analysis showed that the difference in 5 factors was statistically significant (P<0.05):the heat course was >5 days，the heat peak was >39 ℃，the chest film showed lobar pneumonia，the hospital stay was >10 days，and the onset age was <2 years.(2)Logistic regression analysis showed that heat duration >5 days，lobular pneumonia on chest radiograph and onset age <2 years were the main risk factors for MPP complicated with myocardial damage.Conclusion For children with Mycoplasma pneumoniae pneumonia，if fever lasts more than 5 days，chest radiograph indicates lobar pneumonia，and the onset age is less than 2 years，the possibility of being complicated with myocardial damage should be considered.For patients at high risk of MPP complicated with myocardial damage，it is necessary to strengthen management，complete the necessary examinations such as electrocardiography and cardiac color ultrasonography，and actively intervene to improve the prognosis of MPP children. Related Articles | Metrics

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Risk factor analysis of death from mushroom poisoning in children GONG Ling, LU Xiulan, XIAO Zhenghui, HUANG Jiaotian, LI Xun 2022, 14 (4):  326-330.  doi: 10.3969/j.issn.1674-3865.2022.04.013 Abstract ( 653 )   PDF (534KB) ( 49 )   Save Objective To explore the risk factors of death caused by mushroom poisoning in children，in order to make early detection and timely treatment of critical mushroom poisoning，improve prognosis and reduce mortality.Methods A retrospective analysis was performed on 51 children with acute mushroom poisoning admitted to Hunan Children′s Hospital from June 2002 to December 2020，with admission as the starting point of the study and discharge or death as the end point of the study.All cases were divided into survival group and death group，and the study factors included age，gender，hospitalization time，incubation period，complications and organ function indicators.Results Among 51 children with mushroom poisoning，9 died and 42 survived.There was no significant difference in age，gender or incubation period between the two groups (P>0.05).Compared with the survival group，the death group had shorter hospital stay，more damaged organs，and faster disease progression.The organ function damage in the death group was more serious，which was shown by more significant abnormality in aspartate aminotransferase，total bilirubin，direct bilirubin，blood ammonia(NH4)，prothrombin time(PT) and antithrombin Ⅲ(AT3)，international normalized ratio(INR)，creatine kinase isoenzyme(CK-MB)，white blood cell count，platelets and lactate，compared with the survival group，and the differences were statistically significant(P<0.05)，while there was no significant difference in renal function or electrolytes between the two groups.Univariate Logistic regression analysis showed that CK-MB，PT，white blood cell count，NH4，total bilirubin，direct bilirubin，INR，platelets and lactate were all positively correlated with death，while AT3 was negatively correlated with death.Conclusion The increase in CK-MB，PT，white blood cell count，NH4，total bilirubin，direct bilirubin serum，INR，platelets and lactate and the decrease in AT3 are risk factors for death from mushroom poisoning. Related Articles | Metrics

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Effect of collective language training on developmental level and neurotrophic factor level in children with language development delay XIA Qiong, CHEN Jianshu, HUANG Fengwu, HU Li 2022, 14 (4):  331-334.  doi: 10.3969/j.issn.1674-3865.2022.04.014 Abstract ( 416 )   PDF (480KB) ( 151 )   Save Objective To explore the application effect of collective language training in children with language development delay and its influence on developmental level，language ability and neurotrophic factor level. Methods A total of 89 children with language development delay admitted to our department from September 2019 to March 2021 were selected as the research subjects，who were randomly divided into the control group(44 cases) and the observation group(45 cases).Both groups were given transcranial magnetic stimulation therapy，the control group was given one-on-one language rehabilitation training，and the observation group was given collective language training for treatment.The development level，language ability and neurotrophic factor levels of the two groups were compared.Results Before intervention，there were no significant differences in developmental level，language ability or neurotrophic factor levels between the two groups(P>0.05).After intervention，the scores in adaptability，language，personal social interaction，language understanding，language expression and operation ability in the observation group were higher than those in the control group，and the differences were statistically significant(P<0.05).There was no significant difference in neurotrophic factors between the two groups after intervention(P>0.05).Conclusion Collective language training can significantly improve the developmental level and language ability of children with language development delay，but has no obvious effect on the level of neurotrophic factors in the brain. Related Articles | Metrics

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Analysis of pathogenic factors of cough variant asthma in children SHEN Xiangqing, CHEN Yanxia, GUO Kai 2022, 14 (4):  335-339.  doi: 10.3969/j.issn.1674-3865.2022.04.015 Abstract ( 638 )   PDF (609KB) ( 112 )   Save Objective To explore the related factors of cough variant asthma(CVA) in children in order to provide reference for clinical workMethods Select 40 children with cough variant asthma and 40 healthy children to ask them to fill out a questionnaire on related factors，including gender，age，body mass index，history of allergic rhinitis，history of atopic dermatitis，history of allergic conjunctivitis，history of recurrent respiratory tract infections，history of asthma or chronic cough in grade 1，2 parents，atopic physique (urticaria，eczema，rhinitis) of grade 1，2 parents，history of smoke exposure (including passive smoking，kitchen oil fume，air pollution)，keeping pets or planting flowers and plants at home，laying carpets at home，delivery mode，feeding methods and peripheral blood eosinophils，etc.First perform single factor analysis to remove irrelevant factors，and then perform Logistic regression analysis，and finally get the factors related to the onset of cough variant asthma in children.Results After univariate analysis and logistic regression analysis，history of allergic rhinitis(P=0.002)，history of recurrent respiratory infections(P=0.015) and feeding methods(P=0.049) were related factors for the onset of cough variant asthma in children. Conclusion The onset of cough variant asthma in children is related to history of allergic rhinitis，history of recurrent respiratory infections and no history of breastfeeding.In clinical work，parents should be educated about public science，pay attention to breastfeeding，avoid recurrent respiratory infections，and actively receive treatment for allergic rhinitis in order to prevent the occurrence of CVA in children. Related Articles | Metrics

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Evaluation of the efficacy of Chinese medicine bathing as adjuvant therapy for neonatal hyperbilirubinemia of different etiologies CHEN Hongyu, ZOU Min, WEI Xiaoxia, CHENG Sihua, LI Zhenglin 2022, 14 (4):  339-343.  doi: 10.3969/j.issn.1674-3865.2022.04.016 Abstract ( 788 )   PDF (663KB) ( 125 )   Save Objective To investigate the efficacy of Chinese medicine bathing as adjuvant therapy for neonatal hyperbilirubinemia of different etiologies.Methods A total of 322 infants hospitalized for neonatal hyperbilirubinemia from September 2018 to October 2020 were selected and were divided into two groups:observation group (161 cases) and control group (161 cases)，by random number table method according to different etiologies.Blue light irradiation was used in the control group，and TCM bathing was used in the observation group in addition to the treatment for the control group.The changes of serum total serum bilirubin(TSB)，average daily stool frequency，phototherapy time and efficacy were observed before treatment，48h after treatment and at the end of treatment.Results There was a significant difference in the average number of bowel movement per day between the two groups(P<0.05)，while there was no significant difference in the duration of phototherapy(P>0.05) or the short-term efficacy(P>0.05).TSB at the end of treatment in both groups had statistical significance for breast milk jaundice(P<0.05).The decline of TSB with different etiologies was different in the observation group with treatment time increasing(P<0.05).There were differences between the causes of G-6-PD deficiency and other causes at 48h after treatment (P<0.05)，and also between the causes of G-6-PD deficiency and breast milk jaundice and perinatal high-risk factors at the end of treatment (P<0.05).Conclusion Chinese medicine bathing as adjuvant therapy for neonatal hyperbilirubinemia has the same short-term efficacy as blue light irradiation alone.However，Chinese medicine bathing as adjuvant therapy is more effective for breast milk jaundice，while for G-6-PD deficiency jaundice it is relatively less effective than other etiologies. Related Articles | Metrics

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Meta analysis of Xiaoqinglong decoction in the treatment of infantile bronchiolitis ZHANG Xiuying, WANG Xuefeng, LIU Qing, XU Wentao, YANG Mengfei, WANG Lei 2022, 14 (4):  344-349.  doi: 10.3969/j.issn.1674-3865.2022.04.017 Abstract ( 734 )   PDF (2087KB) ( 70 )   Save Objective To systematically evaluate the efficacy and safety of Xiaoqinglong decoction in the treatment of bronchiolitis in children.Methods The databases of CNKI，Wangfang Date，VIP，CBM Embase，Registry Platform and CENTRAL were systematically searched，and the random controlled trials(RCT) of Xiaoqinglong decoction in the treatment of bronchiolitis in children was included，the search time was from January 2006 to December 2020，and the quality of the trial was evaluated by ROB scale recommended by Cochrane and analyzed by RevMan 5.4 statistical software. Results  A total of 15 randomized controlled trials were included，involving 1 270 subjects.The results of Meta analysis showed that Xiaoqinglong decoction could improve the clinical curative effect compared with the western medicine group［RR=1.21，95%CI(1.16，1.27)，P<0.000 01］.In the aspect of improving the clinical symptoms and signs，such as shortening the antipyretic time，the disappearance time of cough，the disappearance time of asthma，the disappearance time of lung rale and wheezing，the effect of Xiaoqinglong decoction was better than that of the control group，and the difference was statistically significant(P< 0.05).Conclusion Xiaoqinglong decoction can improve the clinical effect，shorten the hospitalization time and improve the clinical symptoms in the treatment of bronchiolitis in children.However，due to the limited number of included studies and the low quality of methodology，it still needs to be confirmed by high-quality and large-sample RCT. Related Articles | Metrics

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Analysis of medication rules of Professor Zhang Baoqing in treatment of child autism with paste prescription SUN Ning, ZHANG Baoqing 2022, 14 (4):  350-354.  doi: 10.3969/j.issn.1674-3865.2022.04.018 Abstract ( 496 )   PDF (812KB) ( 391 )   Save Objective To analyze the medication and prescription rules of Professor Zhang Baoqing in the application of paste prescription for child autism by using "Chinese medicine inheritance assistance system platform"，and to provide ideas for Chinese medicine treatment for child autism. Methods Collect the cases of child autism treated by Professor Zhang Baoqing with paste prescriptions and input the data of prescriptions into the Chinese medicine inheritance assistant system platform（V2.5）.Analyze medication rules in Professor Zhang Baoqing′s use of paste prescription for child autism.Results A total of 105 herbal medicines were found in 60 paste prescriptions.The top 5 herbal medicines which were used frequently were Shichangpu(Acorus tatarinowii)，Yizhiren(bitter cardamon)，Chenpi(Pericarpium citri reticulatae)，Yuanzhi(Polygala tenuifolia willd) and Fushen(Radix polygalae).The commonly used medicine pairs included Qingbanxia(Slum processed pinellia)-Chenpi(Pericarpium citri reticulatae)，Qingbanxia(Slum processed pinellia)-Huanglian(Coptis).Conclusion Most of the paste prescriptions for child autism include drugs dissipating phlegm for resuscitation，sedative and heart-invigorating drugs，qi-regulating drugs and dampness-transforming drugs.The main principle of treatment is to dissipate phlegm for resuscitation，restore consciousness and calm the mind. Related Articles | Metrics

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Research on clinical data mining of traditional Chinese medicine in the treatment of Henoch-Schnlein purpura damp heat syndrome SONG Yehong, CAO Zhiyuan, DIAO Juanjuan 2022, 14 (4):  355-360.  doi: 10.3969/j.issn.1674-3865.2022.04.019 Abstract ( 554 )   PDF (1014KB) ( 100 )   Save Objective To analyze the law of traditional Chinese medicine prescription for damp-heat allergic purpura.Methods The Chinese Journal Full-text database，VIP database and Wanfang database were searched for literature related to Chinese medicine treatment for damp-heat allergic purpura.The data were processed and the database was established.The frequency analysis，association rule analysis and cluster analysis were carried out by using Excel 2019，SPSS modeler 18.0 and SPSS statistics 22.0.Results A total of 101 prescriptions were screened，involving 159 Chinese medicines and 22 high-frequency Chinese medicines，mainly including coix seed，Phellodendron amurense and Atractylodes macrocephala.The medicines were mainly cold，and the medicines were mostly bitter，sweet or pungent.The medicines functioned mainly through liver，lung，spleen and stomach meridians.The results of association rules showed that coix seed，Cortex phellodendri，Atractylodes lancea，Achyranthes bidentata，Arnebia，peony bark，madder and white grass root were closely related.Five clusters were obtained by cluster analysis. Conclusion The clinical treatment for damp heat syndrome of Henoch-Schnlein purpura mainly focus on the pathological factors such as "dampness"，"heat" and "blood stasis".The prescriptions reflect the characteristics of "clearing heat and dampness and removing blood stasis and hemostasis".The "Simiao pill" is commonly used to add and subtract the main formula of clearing heat and dampness，and flexible combination with "activating blood and removing blood stasis" can remove damp heat，eliminate blood stasis and restore healthy qi，and the disease is cured. Related Articles | Metrics

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Professor Zheng Jian's treatment for primary nephrotic syndrome in children based on "kidney governing deficiency YANG Lan, ZHUANG Xiangli, YAN Shuiping, ZHENG Jian 2022, 14 (4):  361-364.  doi: 10.3969/j.issn.1674-3865.2022.04.020 Abstract ( 522 )   PDF (615KB) ( 129 )   Save Primary nephrotic syndrome(PNS) is one of the common renal diseases in children. There are many deficiencies and drawbacks in traditional western medicine treatment. In recent years, the treatment with integrated traditional Chinese and western medicine has achieved fruitful results. The author analyzes and summarizes Prof. Zheng Jian's experience in the treatment of PNS in order to provide ideas for the clinical treatment of children with nephropathy. Since Qian Yi of Song Dynasty put forward the idea of "kidney governing deficiency, no excess", the style of kidney without excess has prevailed among generations of physicians. However, the kidney excess has long been recorded in ancient medical books，which are discussed in the works such as Inner Canon of Huangdi, Synopsis of Golder Chamber and Maijing. Professor Zheng Jian believes that Qian's views can be interpreted as "kidneys usually govern deficiency, and there is also excess". Based on this thought, Prof. Zheng concludes that the pathogenesis of pediatric PNS in traditional Chinese medicine is mainly based on kidney deficiency, but in the course of the disease, there may also be symptoms caused by wind pathogens, blood stasis, damp-heat and other pathogens. The disease often has the characteristics of deficiency in root and excess in appearance, mixed deficiency with excess, repeated occurrence, protraction and difficulty in healing,etc.; therefore,in the clinical diagnosis, it is necessary to distinguish between the primary and secondary and between deficiency and excess of kidney disease according to the course of the disease. In the treatment, while dealing with the kidney deficiency, it's necessary to eliminate wind, remove dampness, clear heat and remove blood stasis, etc., which can benefit the lungs, strengthen the spleen, warm the kidneys, clear the liver, strengthen the body and reduce turbidity to regulate the yin and yang of various internal organs. Professor Zheng has been a doctor for more than 30 years, and he has been using this method in the treatment of children with PNS, which has great effects. A medical record is attached for verification. Related Articles | Metrics

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Clinical experience of TCM treatment for adenoid hypertrophy in children LIU Jun, ZONG Chenxu, GE Meifei, MA Yuexiang 2022, 14 (4):  365-368.  doi: 10.3969/j.issn.1674-3865.2022.04.021 Abstract ( 800 )   PDF (677KB) ( 345 )   Save Adenoid hypertrophy is a common disease during childhood, and the incidence has been increasing in the recent years, which seriously affect the children's growth and psychological development. Therefore, non-surgical treatment is very important. The treatment of traditional Chinese medicine(TCM) has achieved great success.Through analyzing the etiology and pathogenesis of adenoid hypertrophy in children and based on the children's pathophysiological characteristics, the treatment methods and principles are formed in clinical treatment, which provides evidence for making prescriptions and choosing drugs. Meanwhile, attention is paid to the differentiated treatment and the treatment of both symptoms and causes; different treatment is given at different stages of disease. Following the concept of wholism and green medicine and based on the clinical mechanism of combined internal and external treatment in TCM, the Chinese medicines, medicinal congee, blood-letting puncture and cupping, indirect moxibustion and massage are effectively combined to reduce the adenoid body and make the recurrence unlikely. This practice makes it possible to avoid surgeries, and the children and their parents are willing to accept. It increases the clinical effect of TCM treatment for children with adenoid hypertrophy, provides a new way of clinical treatment for adenoid hypertrophy in children, and is worthy of clinical promotion. A medical record is attached for verification.  Related Articles | Metrics